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John D. Wiley Seminar Series
Date: May 25, 2012
Time: Noon to 1:00 pm
Jenny Hsieh, PhD
Title: "Timing Is Everything: Development of New Neurons in the Adult Brain"
Speaker: Jenny Hsieh, PhD
Assistant Professor Molecular Biology Program
Genetics and Development Neuroscience
UT Southwestern Medical Center
About the Talk: Stem cells have generated hype, headlines, and hope, representing a source of replacement cells to treat a host of medical conditions. Tucked away in specialized niches, these ever changing cells maintain tissue homeostasis and rejuvenate organs. Balancing the equation between cellular supply and demand is especially important in the adult brain as neural stem cells (NSCs) in two discrete regions, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) next to the lateral ventricles, continuously self-renew and differentiate into new neurons in a process called adult neurogenesis. Through the interplay of intrinsic and extrinsic factors, adult neurogenic niches ensure neuronal turnover throughout life, contributing to brain plasticity. Here I will present our progress on the molecular control of adult neurogenesis in the SGZ and SVZ, focusing on the role of specific transcription factors and epigenetic regulators that mediate the timely progression from neural stem cells (NSCs) to lineage-committed progenitors and ultimately, the generation of mature neurons and glia. Our work highlights a potential set of novel molecular targets for reprogramming and neuroregenerative approaches. Funding Acknowledgment: NIH-AG032383, -NS076775, -MH09471501, CPRIT grant RP100674 and Welch Foundation grant I-1660.
About the Speaker: Research in the Hsieh laboratory explores the development and function of resident adult neural stem cells, which are a source of inherent plasticity in the mammalian brain center (hippocampus) critical for learning and memory. We study neural stem cells using a range of novel genetic, pharmacological, cellular, molecular, and imaging methods. A major focus of the lab is to understand the transcriptional/epigenetic regulatory circuitry that guides neural stem cell fate decisions in both physiological and pathological states.
Where: John D. Wiley Conference Center, Room T216, Second Floor, North Tower
For Further Information: Contact Teresa Palumbo at 263-5837 or palumbo@waisman.wisc.edu
This Seminar Series is partially funded by the John D. Wiley Conference Center Fund, the Friends of the Waisman Center and NIH grant P30 HD003352.
