Date: February 22, 2008
Time: Noon to 1:00
Title: “Therapies for - and from - Down syndrome”
Speaker: Roger Reeves, PhD
Johns Hopkins University School of Medicine
Where: Waisman Conference Center
Room T216, Second Floor, North Tower
About the Talk:
Mouse models provide a critical bridge for translating genomic information into biology. In this presentation I will describe the construction and characterization of mouse genetic models for Down syndrome (DS) and demonstrate applications to the question of the genetic contribution of trisomy to cognitive function and other DS phenotypes. The basis for and potential treatment of a developmental neuronal deficit characteristic of the DS brain will be discussed. Lastly, recent observations addressing a 50 year old controversy about reduced solid tumor incidence in DS will be presented.
About Terrence R. Dolan:
Terrence R. Dolan received his Ph.D. in 1966 in an interdisciplinary program of psychology, physiology, and anatomy at the University of Texas, Austin. He was a post-doctoral fellow at the Center for Neurosciences, Indiana University from 1966-68 and stayed on as a research associate for another two years. From 1970-1976, Dolan was affiliated with the Loyola University of Chicago. He held positions as professor of psychology and assistant dean of the Graduate School and also served as director of Loyola's Parmly Research Institute. Prior to beginning his tenure at the Waisman Center, he spent a year as a Von Humboldt fellow and directed the National Science Foundation's Sensory Physiology and Perception Program in Washington, D.C. Dolan was appointed director of the Waisman Center on May 24, 1982. A professor in the Departments of Neurology and Psychology, he made many lasting contributions to the Waisman Center during the next two decades. He broadened the center's research programs in the behavioral sciences, most notably in the areas of aging, sensory and perceptual processes, and speech and language sciences; he expanded the center's research into several new areas of science, including gene therapy and stem cell biology; and he facilitated partnerships between the Waisman Center and the public and private sectors. He also guided the planning and development of a 70,000 square-foot addition, which houses a highly specialized biomanufacturing facility, a state-of-the-art functional brain imaging center, research floors dedicated to stem cell and gene therapy research, and remodelled and new space for the center's early childhood programs. Dolan retired from UW-Madison on May 24, 2002. He and his wife Mary Ann have four children and six grand children.
Where: Waisman Conference Center
Room T216, Second Floor, North Tower
For Further Information: Contact Teresa Palumbo at 263-5837 or
palumbo@waisman.wisc.edu
The Waisman Center Seminar Series is partially funded by the
Friends of the Waisman Center and NIH grant P30 HD003352.
