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2011 Fall Seminar Series (pdf)
John D. Wiley Seminar Series
Date: November 4, 2011
Time: Noon to 1:15
Timothy Bestor, PhD
Title: "Biology of Genomic Methylation Patterns"
Speaker: Timothy Bestor, PhD
Professor of Genetics and Development
College of Physicians and Surgeons of Columbia University
About the Talk: Some mammalian promoters are inactive even when in the presence of all the factors necessary for their expression; imprinted genes and genes on the inactive X chromosomes are not expressed, even though the identical allele on the homologous chromosome may be expressed at high levels. The states of activity of such genes are subject to somatic inheritance. Genes subject to heritable silencing are said to be under epigenetic regulation. Most epigenetic regulation in mammals depends on the establishment and maintenance of genomic methylation patterns. Transcription of mammalian genes is prevented by the methylation of cytosines within promoter elements, and methylation patterns are transmitted during cell division with very high fidelity. It was previously thought that reversible promoter methylation might be involved in gene regulation during development, but recent data indicate that the primary function of DNA methylation is the suppression of intragenomic parasites and of proviral DNA. DNA methylation also has crucial roles in genomic imprinting and X chromosome inactivation in females.
Where: John D. Wiley Conference Center, Room T216, Second Floor, North Tower
For Further Information: Contact Teresa Palumbo at 263-5837 or palumbo@waisman.wisc.edu
This Seminar Series is partially funded by the John D. Wiley Conference Center Fund, the Friends of the Waisman Center and NIH grant P30 HD003352.
