![Craig Berridge]](PH-BERRIDGE.JPG) |
Craig Berridge |
My research focuses on the actions of certain transmitters in the regulation of behavioral state and state-dependent cognitive processes (working memory, attention). Specifically, we are interested in the catecholamine (i.e. dopamine, norepinephrine) and certain peptide neurotransmitters (CRF, hypocretin) and their actions under normal and stressful conditions. Currently there are 4 main themes: 1) Neurobiology of Waking; 2) Neural Mechanisms of Amphetamine-Induced Arousal; 3) Neurobiology of Low-Dose Methylphenidate (Ritalin): Relevance to ADHD; 4) Neurobiology of stress and coping. Recent work begins to examine the actions of low-dose methylphenidate, hypocretin and CRF on catecholamine neurotransmission within the prefrontal cortex and the electrophysiological and behavioral consequences of these actions. We believe our work with methylphenidate will provide much needed insight into the neural mechanisms underlying both ADHD and the therapeutic actions of a widely-prescribed class of drugs. In all of our work, we take a multidisciplinary approach in which a variety of methods are utilized, including pharmacological, electrophysiological, anatomical, and neurochemical techniques.
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Berridge CW (2009) The Locus Coeruleus-Noradrenergic System and Stress: Implications for Post-Traumatic Stress Disorder. In: Posttraumatic Stress Disorder: Basic Science and Clinical Practice, edited by PJ Shiromani, TM Keane and JE LeDoux. Chapter 10. Humana/Springer, New York, NY. Stalnaker TA, España RA, Berridge CW. (2009) Coping behavior causes asymmetric changes in neuronal activation in the prefrontal cortex and amygdala. Synapse. Jan;63(1):82-5. Vittoz NM, Schmeichel B, Berridge CW. (2008) Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons. European Journal of Neuroscience. Oct;28(8):1629-40. Devilbiss DM, Berridge CW. (2008) Cognition-enhancing doses of methylphenidate preferentially increase prefrontal cortex neuronal responsiveness. Biological Psychiatry. Oct 1;64(7):626-35. Berridge CW.(2008) Noradrenergic modulation of arousal. Brain Research Reviews. 2008 Jun;58(1):1-17. Berridge CW, Devilbiss DM, Andrzejewski ME, Arnsten AFT, Kelley AE, Schmeichel B, Hamilton C, Spencer RC (2006) Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biological Psychiatry, 60:1111-1120. Devilbiss DM, Berridge CW. (2006) Low-dose methylphenidate actions on tonic and phasic locus coeruleus discharge. Journal of Pharmacology Experimental Therapeutics. Dec;319(3):1327-35. Berridge CW. (2006) Neural substrates of psychostimulant-induced arousal. Neuropsychopharmacology. Nov;31(11):2332-40. Vittoz NM and Berridge CW (2005) Hypocretin/Orexin selectively increases dopamine efflux within the prefrontal cortex: involvement of the ventral tegmental area. Neuropsychopharmacology, Epub ahead of print. Berridge CW and España RA (2005) Hypocretins: Waking, Arousal or Action? Neuron, 46:696-698. España RA, Reis KM, Valentino RJ, and Berridge CW (2005) Organization of Hypocretin Efferents to Locus Coeruleus and Basal Forebrain Arousal-Related Structures. Journal of Comparative Neurology, 481:160-178. Berridge CW and Waterhouse BD (2003) Modulatory Actions of the Locus Coeruleus-Noradrenergic System on Behavioral State and State-Dependent Cognitive Processes. Brain Research Reviews 42:33-84. Berridge CW and Stalnaker TA (2002) Relationship between low-dose amphetamine-induced arousal and extracellular norepinephrine and dopamine levels within prefrontal cortex. Synapse, 46:140-149.
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