Sunduz Keles
Ph.D., University of California, Berkeley
Associate Professor, Statistics and Biostatistics & Medical Informatics

Contact Information:
UW-Madison
K6/440 Clinical Sciences Center
600 Highland Avenue
Madison, WI 53792-4675
Phone: (608) 263-4533
Fax: (608) 265-5579
E-mail: keles@stat.wisc.edu

Research Statement

I am interested in statistical and computational genomics. Our research concerns developing and applying statistical methods for problems that arise in genome biology.

Representative Publications

S. Keles, M. R. Segal (2002). Residual-based tree-structured survival analysis. Statistics in Medicine, 21: 313-326.

S. Keles, M. J. van der Laan, M. B. Eisen (2002). Identification of regulatory elements using a feature selection method. Bioinformatics, 18: 1167-1175.

S. Keles, M. J. van der Laan, S. Dudoit, B. Xing, M. B. Eisen (2003). Supervised detection of regulatory motifs in DNA sequences. Statistical Applications in Genetics and Molecular Biology, Vol. 2, No. 1, Article 5.

S. Dudoit, M. J. van der Laan, S. Keles, A. M. Molinaro, S. E. Sinisi, and S. L. Teng (2003). Loss-based estimation with cross-validation: applications to microarray data analysis and motif finding. SIGKDD Explorations, 5(2):37-49.

S. Keles, M. J. van der Laan, J. M. Robins (2004). Estimation of the bivariate survival function with right censored data structures. Handbook of Statistics, Volume 23: Advances in Survival Analysis, edited by N. Balakrishnan and C.R. Rao.

M. Miloslavsky, S.Keles, M. J. van der Laan, S. Butler (2004). Recurrent events analysis in the presence of time dependent covariates and dependent censoring. Journal of Royal Statistical Society Series B (Statistical Methodology), 66(1):239-257.

J. De Freitas, J. Kim, H. Poynton, T. Su, H. Wintz, T. Fox, P. Holman, A. Loguinov, S. Keles, M. J. van der Laan, and C. Vulpe (2004). Exploratory and confirmatory gene expression profiling of mac1. Journal of Biological Chemistry, 2(6):4450-4458.

M. J. van der Laan, S. Dudoit, S. Keles (2004). Asymptotic optimality of likelihood based cross-validation. Statistical Applications in Genetics and Molecular Biology, Vol. 3: No. 1, Article 4.

S. Keles, M. J. van der Laan, C. Vulpe (2004). Regulatory motif finding using logic regression. Bioinformatics, 20(16):2799-2811.

S. Keles, M.J. van der Laan, and S. Dudoit (2004). Asymptotically optimal model selection method for regression on censored outcomes. Bernoulli, 10 (6): 1011-1037.

H. Cinar, S. Keles and Y. Jin (2004). Identity of GABA motor neurons in C. elegans. To appear, Current Biology.

F. Lu, S. Keles, S. Wright, and Wahba, G. (2005) A Framework for Kernel Regularization With Application to Protein Clustering. PNAS, 102(35): 12332-12337.

H. Cinar, S. Keles, and Y. Jin (2005). Expression Profiling of GABAergic Motor Neurons in Caenorhabditis elegans. Current Biology, 15(4): 340 -346. (Journal website).

S. Keles, M. J. van der Laan, Sandrine Dudoit, and Simon E. Cawley (2006). Multiple Testing Methods for ChIP-Chip High Density Oligonucleotide Array Data. Journal of Computational Biology. 13(3):579-613.