Anita Bhattacharyya, PhD

Position title: Associate Professor, Cell and Regenerative Biology

Anita Bhattacharyya, PhD

PhD, University of Cincinnati
Co-Core Director, IDD Models
Sub-Core Director, hPSC Services

Contact Information

Waisman Center
1500 Highland Avenue
Room 623
Madison, WI 53705
608-265-6142
bhattacharyy@waisman.wisc.edu
Bhattacharyya Lab at UW-Madison

Research Statement

I have built my research career on a longstanding interest in developmental biology. I pursued foundational training in developmental neurobiology, growth factor signaling and human neural stem cells to gain knowledge and technical expertise into the mechanisms that underlie neural development. I embraced the reprogramming technology that enabled the conversion of adult cells to induced pluripotent stem cells (iPSCs), thus facilitating the generation of disease specific stem cells. My lab was one of the first to establish human stem cell models of neurodevelopmental disorders including Down syndrome and Fragile X. I use these research tools to cultivate a robust and productive research program to investigate developmental mechanisms that underlie intellectual disability in neurodevelopmental disorders.

My primary research effort is understanding altered brain development in Down syndrome. Down syndrome is the most common genetic cause of intellectual disability and the most common genetic cause of Alzheimer’s disease. Neurodevelopmental impairment and neuronal dysfunction contribute to the hallmark cognitive disability in individuals with Down syndrome. Little is known about what and how specific neurons are affected and what molecular pathways underlie defects that lead to intellectual disability. Consequently, attempts to effectively design therapeutic targets or interventions are limited. The goal of my research is to fill this gap with foundational knowledge about Down syndrome brain development and to leverage the human stem cell models that I generated to test hypotheses and define cellular and molecular alterations.

Neuropathology in Down syndrome progresses along a continuum from prenatal disruptions to the manifestations of age-related conditions and Alzheimer’s disease. More recently, my lab has begun to address gaps in our understanding of how neurodevelopment and neurodegeneration are linked in Down syndrome across the lifespan.

Selected Publications

Pubmed