Bradley T Christian

Bradley T Christian, PhD

PhD, University of Wisconsin-Madison
Director of PET Physics, Waisman Brain Imaging Lab
Associate Professor of Medical Physics and Psychiatry

Contact Information:

Waisman Center
1500 Highland Avenue
Room T231
Madison, WI 53705
608.890.0750
bchristian@wisc.edu
Lab Website: Waisman Laboratory for Brain Imaging and Behavior

Research Statement

Our research focuses on developing and translating novel PET methods for the study of neurodevelopment and neuropsychiatric illness. This involves using PET methodologies to investigate neurochemical changes in the brain and studying novel radioligands to characterize neurotransmitter-protein interactions and how they are influenced by development, genes, environment and drugs. These imaging methods are being applied to investigate the etiologies and mechanisms in diseases such as Down syndrome, affective disorders, schizophrenia, Alzheimer's disease and Tourette syndrome.

Representative Publications

Clark LR, Racine AM, Koscik RL, Okonkwo OC, Engelman CD, Carlsson CM, Asthana S, Bendlin BB, Chappell R, Nicholas CR, Rowley HA, Oh JM, Hermann BP, Sager MA, Christian BT, Johnson SC. (2016) Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study. Alzheimers & Dementia. In Press.

Willette AA, Johnson SC, Birdsill AC, Sager MA, Christian B, Baker LD, Craft S, Oh J, Statz E, Hermann BP, Jonaitis EM, Koscik RL, La Rue A, Asthana S, Bendlin BB. (2015) Insulin resistance predicts brain amyloid deposition in late middle-aged adults. Alzheimer's & Dementia. 11(5):504-510.e1. doi: 10.1016/j.jalz.2014.03.011.

Johnson SC, Christian BT, Okonkwo OC, Oh JM, Harding S, Xu G, Hillmer AT, Wooten DW, Murali D, Barnhart TE, Hall LT, Racine AM, Klunk WE, Mathis CA, Bendlin BB, Gallagher CL, Carlsson CM, Rowley HA, Hermann BP, Dowling NM, Asthana S, Sager MA. (2014) Amyloid burden and neural function in people at risk for Alzheimer's Disease. Neurobiology of Aging. 35(3):576-84.

Wooten DW, Hillmer AT, Murali D, Barnhart TE, Thio JP, Bajwa AK, Bonab AA, Normandin MD, Schneider ML, Mukherjee J, Christian BT. (2014) Initial in vivo PET imaging of 5-HT1A receptors with 3-[(18)F]mefway. American Journal of Nuclear Medicine and Molecular Imaging. 15;4(5):483-9.

Okonkwo OC, Schultz SA, Oh JM, Larson J, Edwards D, Cook D, Koscik R, Gallagher CL, Dowling NM, Carlsson CM, Bendlin BB, LaRue A, Rowley HA, Christian BT, Asthana S, Hermann BP, Johnson SC, Sager MA. (2014) Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology. 4;83(19):1753-60. doi: 10.1212/WNL.0000000000000964.

Hillmer AT, Wooten DW, Tudorascu DL, Barnhart TE, Ahlers EO, Resch LM, Larson JA, Converse AK, Moore CF, Schneider ML, Christian BT. (2014) The effects of chronic alcohol self-administration on serotonin-1A receptor binding in nonhuman primates. Drug and Alcohol Dependence. 144:119-26.

Hillmer AT, Tudorascu DL, Wooten DW, Lao PJ, Barnhart TE, Ahlers EO, Resch LM, Larson JA, Converse AK, Moore CF, Schneider ML, Christian BT. (2014) Changes in the α4β2* nicotinic acetylcholine system during chronic controlled alcohol exposure in nonhuman primates. Drug and Alcohol Dependence. 138:216-9.

Tomer R, Slagter HA, Christian BT, Fox AS, King CR, Murali D, Gluck MA, Davidson RJ. (2014) Love to win or hate to Lose? Asymmetry of dopamine D2 receptor binding predicts sensitivity to reward versus punishment. Journal of Cognitive Neuroscience. 26(5):1039-48.

Racine AM, Adluru N, Alexander AL, Christian BT, Okonkwo OC, Oh J, Cleary CA, Birdsill A, Hillmer AT, Murali D, Barnhart TE, Gallagher CL, Carlsson CM, Rowley HA, Dowling NM, Asthana S, Sager MA, Bendlin BB, Johnson SC. (2014) Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation. Neuroimage. Clinical. 19;4:604-14.

Okonkwo OC, Oh JM, Koscik R, Jonaitis E, Cleary CA, Dowling NM, Bendlin BB, Larue A, Hermann BP, Barnhart TE, Murali D, Rowley HA, Carlsson CM, Gallagher CL, Asthana S, Sager MA, Christian BT, Johnson SC. (2014) Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer's disease. Journal of the International Neuropsychological Society. 20(4):422-33.

Hartley SL, Handen BL, Devenny DA, Hardison R, Mihaila I, Price JC, Cohen AD, Klunk WE, Mailick MR, Johnson SC, Christian BT. (2014) Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome. Brain. 137(Pt 9):2556-63.

Peng Y, Li M, Clarkson BD, Pehar M, Lao PJ, Hillmer AT, Barnhart TE, Christian BT, Mitchell HA, Bendlin BB, Sandor M, Puglielli L. (2014) Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer. Journal of Neuroscience. 14;34(20):6772-89. doi: 10.1523/JNEUROSCI.0077-14.2014.

Li CT, Palotti M, Holden JE, Oh J, Okonkwo O, Christian BT, Bendlin BB, Buyan-Dent L, Harding SJ, Stone CK, DeJesus OT, Nickles RJ, Gallagher CL. (2014) A dual-tracer study of extrastriatal 6-[18F]fluoro-m-tyrosine and 6-[18F]-fluoro-L-dopa uptake in Parkinson's disease. Synapse. 68(8):325-31.

Converse AK, Moore CF, Holden JE, Ahlers EO, Moirano JM, Larson JA, Resch LM, DeJesus OT, Barnhart TE, Nickles RJ, Murali D, Christian BT, Schneider ML. (2014) Moderate-level prenatal alcohol exposure induces sex differences in dopamine d1 receptor binding in adult rhesus monkeys. Alcoholism: Clinical and Experimental Research. 38(12):2934-43. doi: 10.1111/acer.12575.

Wooten DW, Hillmer AT, Moirano JM, Tudorascu DL, Ahlers EO, Slesarev MS, Barnhart TE, Mukherjee J, Schneider ML, Christian BT. (2013) 5-HT1A sex based differences in Bmax, in vivo KD, and BPND in the nonhuman primate. NeuroImage. 15;77:125-32.

Murali D, Barnhart TE, Vandehey NT, Christian BT, Nickles RJ, Converse AK, Larson JA, Holden JE, Schneider ML, Dejesus OT. (2013) An efficient synthesis of dopamine transporter tracer [¹⁸F]FECNT. Applied Radiation and Isotopes. 72:128-32.

Converse AK, Moore CF, Moirano JM, Ahlers EO, Larson JA, Engle JW, Barnhart TE, Murali D, Christian BT, Dejesus OT, Holden JE, Nickles RJ, Schneider ML. (2013) Prenatal Stress Induces Increased Striatal Dopamine Transporter Binding in Adult Nonhuman Primates. Biological Psychiatry. 1;74(7):502-10.

Hillmer AT, Wooten DW, Slesarev MS, Ahlers EO, Barnhart TE, Schneider ML, Mukherjee J, Christian BT. (2013) Measuring α4β2* nicotinic acetylcholine receptor density in vivo with [(18)F]nifene PET in the nonhuman primate. Journal of Cerebral Blood Flow & Metabolism. 33(11):1806-14.

Tomer R, Slagter HA, Christian BT, Fox AS, King CR, Murali D, Davidson RJ. (2013) Dopamine asymmetries predict orienting bias in healthy individuals. Cerebral Cortex. 23(12):2899-904.

Christian BT, Wooten DW, Hillmer AT, Tudorascu DL, Converse AK, Moore CF, Ahlers EO, Barnhart TE, Kalin NH, Barr CS, Schneider ML. (2013) Serotonin transporter genotype affects serotonin 5-HT1A binding in primates. Journal of Neuroscience. 6;33(6):2512-6.

Slagter HA, Tomer R, Christian BT, Fox AS, Colzato LS, King CR, Murali D, Davidson RJ. (2012) PET evidence for a role for striatal dopamine in the attentional blink: functional implications. Journal of Cognitive Neuroscience. 24(9):1932-40.

Wooten D, Hillmer A, Murali D, Barnhart T, Schneider ML, Mukherjee J, Christian BT. (2011) An in vivo comparison of cis- and trans-[18F]mefway in the nonhuman primate. Nuclear Medicine and Biology. 38(7):925-32.

Christian BT, Vandehey NT, Floberg JM, Mistretta CA. (2010) Dynamic PET denoising with HYPR processing. Journal of Nuclear Medicine. 51(7):1147-54.

Bartlett RM, Dejesus OT, Barnhart TE, Nickles RJ, Christian BT, Graner JL, Holden JE. (2010) Fetal dopamine receptor characteristics assessed in utero. Journal of Cerebral Blood Flow & Metabolism. 30(8):1437-40.

Vandehey NT, Moirano JM, Converse AK, Holden JE, Mukherjee J, Murali D, Nickles RJ, Davidson RJ, Schneider ML, Christian BT. (2010) High-affinity dopamine D-2/D-3 PET radioligands F-18-fallypride and C-11-FLB457: A comparison of kinetics in extrastriatal regions using a multiple-injection protocol. Journal of Cerebral Blood Flow & Metabolism. 30(5):994-1007.

Christian BT, Vandehey NT, Fox AS, Murali D, Oakes TR, Converse AK, Nickles RJ, Shelton SE, Davidson RJ and Kalin NH. (2009) The distribution of D2/D3 receptor binding in the adolescent rhesus monkey using small animal PET imaging. Neuroimage. 44:1334-1344.

Oler JA, Fox AS, Shelton SE, Christian BT, Murali D, Oakes TR, Davidson RJ, Kalin NH. (2009) Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity. Journal of Neuroscience. 12;29(32):9961-6.

Vandehey NT, Garell PC, Hampel JA, Murali D, Smith EM, Davidson R, Converse AK, Nickles RJ and Christian BT. (2009) PET measurement of changes in D2/D3 dopamine receptor binding in a nonhuman primate during chronic deep brain stimulation of the bed nucleus of the stria terminalis. Journal of Neuroscience Methods. 176:129- 135.

Christian BT, Fox AS, Oler JA, Vandehey NT, Murali D, Rogers J, Oakes TR, Shelton SE, Davidson RJ, Kalin NH. (2009) Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET. Neuroimage. Oct 1;47(4):1230-6.