MD, PhD, University of Michigan - Ann Arbor
Associate Professor, Ophthalmology and Visual Sciences
RRF Emmett A. Humble Distinguished Director McPherson Eye Research Institute
Sandra Lemke Trout Chair in Eye Research
Waisman Center Stem Cell Research Program
Inherited and acquired degenerative diseases of the retina are a significant cause of incurable vision loss worldwide. Closer to home, I see the impact of these diseases on afflicted individuals and their families in my pediatric ophthalmology practice at the University of Wisconsin. As such, my laboratory at the Waisman Center utilizes stem cell technology to 1) investigate the cellular and molecular events that occur during human retinal differentiation and 2) generate cells for use in human retinal disease modeling and cell-based rescue or replacement strategies. To meet these goals, we utilize a variety of human cell types, including ES and iPS cells, which have the capacity to mimic retinal development and disease, as well as to delineate the genetic "checkpoints" necessary to produce particular retinal cell types. By understanding the behavior of these cell types in vitro and in vivo, we hope to optimize strategies to delay or reverse the effects of blinding disorders such as retinitis pigmentosa and age–related macular degeneration.
Phillips MJ, Perez ET, Martin JM, Reshel ST, Wallace KA, Capowski EE, Singh R, Wright LS, Clark EM, Barney PM, Stewart R, Dickerson SJ, Miller MJ, Percin EF, Thomson JA, Gamm DM. (2014) Modeling human retinal development with patient-specific iPS cells reveals multiple roles for VSX2. Stem Cells. In press.
Wright LS, Phillips MJ, Pinilla I, Hei D, Gamm DM. (2014) Induced pluripotent stem cells as custom therapeutics for retinal repair: Progress and rationale. Experimental Eye Research. In press.
Gamm DM, Wright LS. (2013) From embryonic stem cells to mature photoreceptors. Nature Biotechnology. 31(8):712-3.
Singh R, Shen W, Kuai D, Martin JM, Guo X, Smith MA, Perez ET, Phillips MJ, Simonett JM, Wallace KA, Verhoeven AD, Capowski EE, Zhang X, Yin Y, Halbach PJ, Fishman GA, Wright LS, Pattnaik BR, Gamm DM. (2013) iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration. Human Molecular Genetics. 22(3):593-607.
Gamm DM, Phillips MJ, Singh R. (2013) Modeling retinal degenerative diseases with human iPS-derived cells: current status and future implications. Expert Review of Ophthalmology. 8(3):213-216.
Phillips MJ, Wallace KA, Dickerson SJ, Miller MJ, Verhoeven A, Martin JM, Wright L, Shen W, Capowski EE, Percin EF, Perez ET, Zhong X, Canto-Soler MV, Gamm DM. (2012) Blood-derived Human iPS Cells Generate Optic Vesicle-like Structures with the Capacity to Form Retinal Laminae and Develop Synapses. Investigative Ophthalmology & Visual Science. 53(4):2007-19.
Meyer JS, Howden SE, Wallace KA, Verhoeven AD, Wright LS, Capowski EE, Pinilla I, Martin JM, Tian S, Stewart R, Pattnaik B, Thomson JA, Gamm DM. (2011) Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment. Stem Cells. 29(8):1206-18.
Howden SE, Gore A, Li Z, Fung HL, Nisler BS, Nie J, Chen G, McIntosh BE, Gulbranson DR, Diol NR, Taapken SM, Vereide DT, Montgomery KD, Zhang K, Gamm DM, Thomson JA. (2011) Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy. Proceedings of the National Academy of Sciences USA. 108(16):6537-42.
Lu B, Wang S, Francis PJ, Li T, Gamm DM, Capowski EE, Lund RD. (2010) Cell transplantation to arrest early changes in an ush2a animal model. Investigative Ophthalmology & Visual Science. 51(4):2269-76.
Gamm DM, Meyer JS. (2010) Directed differentiation of human induced pluripotent stem cells: a retina perspective. Regenerative Medicine. May;5(3):315-7.