Janet E Lainhart

Janet E Lainhart

MD, Wayne State University
Professor, Psychiatry

Contact Information:

Waisman Center
1500 Highland Avenue
Room T227
Madison, WI 53705
608.262.9667
lainhart@waisman.wisc.edu
Lab Website: Waisman Center for Brain Imaging and Behavior

Research Statement

Dr. Lainhart's research focuses on understanding brain growth, development, and maturation in autism from the prenatal period into adulthood. She leads a multidisciplinary research team that uses high-resolution brain scanning to determine changes in the brain that are specific to autism and linked to clinical symptoms, course, and outcome. The goal of this research is to identify biomarkers of autism that can be used in determining the causes of autism, the brain mechanisms involved, early diagnosis, preventive interventions, and treatment. Dr. Lainhart's research is funded in part by the National Institutes of Mental Health and the Autism Speaks Foundation.

Representative Publications

Dean DC 3rd, Travers BG, Adluru N, Tromp do PM, Destiche DJ, Samsin D, Prigge MB, Zielinski BA, Fletcher PT, Anderson JS, Froehlich AL, Bigler ED, Lange N, Lainhart JE, Alexander AL. (2016) Investigating the Microstructural Correlation of White Matter in Autism Spectrum Disorder. Brain Connectivity. 6(5):415-33. doi: 10.1089/brain.2015.0385.

Farmer CA, Kaat AJ, Mazurek MO, Lainhart JE, DeWitt MB, Cook EH, Butter EM, Aman MG. (2016) Confirmation of the Factor Structure and Measurement Invariance of the Children's Scale of Hostility and Aggression: Reactive/Proactive in Clinic-Referred Children with and without Autism Spectrum Disorder. Journal of Child and Adolescent Psychopharmacology. In Press.

Jantz PB, Bigler ED, Froehlich AL, Prigge MB, Cariello AN, Travers BG, Anderson J, Zielinski BA, Alexander AL, Lange N, Lainhart JE. (2015) Wide range achievement test in autism spectrum disorder: test-retest stability. Psychological Reports. 116(3):674-84. doi: 10.2466/03.15.PR0.116k24w8.

Lainhart JE. (2015) Brain imaging research in autism spectrum disorders: in search of neuropathology and health across the lifespan. Current Opinion in Psychiatry. 28(2):76-82. doi: 10.1097/YCO.0000000000000130.

Zielinski BA, Prigge MB, Nielsen JA, Froehlich AL, Abildskov TJ, Anderson JS, Fletcher PT, Zygmunt KM, Travers BG, Lange N, Alexander AL, Bigler ED, Lainhart JE. (2014) Longitudinal changes in cortical thickness in autism and typical development. Brain. 137(Pt 6):1799-812.

Nielsen JA, Zielinski BA, Fletcher PT, Alexander AL, Lange N, Bigler ED, Lainhart JE, Anderson JS. (2014) Abnormal lateralization of functional connectivity between language and default mode regions in autism. Molecular Autism. 6;5(1):8. doi: 10.1186/2040-2392-5-8.

Travers BG, Bigler ED, Tromp DPM, Adluru N, Froehlich AL, Ennis C, Lange N, Nielsen JA, Prigge MB, Alexander AL, Lainhart JE. (2014) Longitudinal processing speed impairments in males with autism and the effects of white matter microstructureLongitudinal processing speed impairments in males with autism and the effects of white matter microstructure. Neuropsychologia. Neuropsychologia, 53, 137-145.

Prigge MB, Lange N, Bigler ED, Merkley TL, Neeley ES, Abildskov TJ, Froehlich AL, Nielsen JA, Cooperrider JR, Cariello AN, Ravichandran C, Alexander AL, Lainhart JE. (2013) Corpus Callosum Area in Children and Adults with Autism. Research in Autism Spectrum Disorders. 7(2):221-234.

Trontel HG, Duffield TC, Bigler ED, Froehlich A, Prigge MB, Nielsen JA, Cooperrider JR, Cariello AN, Travers BG, Anderson JS, Zielinski BA, Alexander A, Lange N, Lainhart JE. (2013) Fusiform correlates of facial memory in autism. Behavioral Sciences. 3(3):348-71. doi: 10.3390/bs3030348.

Adluru N, Hanlon BM, Lutz A, Lainhart JE, Alexander AL, Davidson RJ. (2013) Penalized Likelihood Phenotyping: Unifying Voxelwise Analyses and Multi-Voxel Pattern Analyses in Neuroimaging. Neuroinformatics. 11(2):227-47.

Nielsen JA, Zielinski BA, Fletcher PT, Alexander AL, Lange N, Bigler ED, Lainhart JE, Anderson JS. (2013) Multisite functional connectivity MRI classification of autism: ABIDE results. Frontiers in Human Neuroscience. 25;7:599. doi: 10.3389/fnhum.2013.00599.

Duffield TC, Trontel HG, Bigler ED, Froehlich A, Prigge MB, Travers B, Green RR, Cariello AN, Cooperrider J, Nielsen J, Alexander A, Anderson J, Fletcher PT, Lange N, Zielinski B, Lainhart J. (2013) Neuropsychological investigation of motor impairments in Autism. Journal of Clinical and Experimental Neuropsychology. 35(8):867-81.

Zielinski BA, Anderson JS, Froehlich AL, Prigge MB, Nielsen JA, Cooperrider JR, Cariello AN, Fletcher PT, Alexander AL, Lange N, Bigler ED, Lainhart JE. (2012) scMRI reveals large-scale brain network abnormalities in autism. PLoS One. 7(11):e49172.

Mazefsky CA, Oswald DP, Day TN, Eack SM, Minshew NJ, Lainhart JE. (2012) ASD, a psychiatric disorder, or both? Psychiatric diagnoses in adolescents with high-functioning ASD. Journal of Clinical Child & Adolescent Psychology. 41(4):516-23.

Travers BG, Adluru N, Ennis C, Tromp do PM, Destiche D, Doran S, Bigler ED, Lange N, Lainhart JE, Alexander AL. (2012) Diffusion tensor imaging in autism spectrum disorder: a review. Autism Research. 5(5):289-313.

Froehlich AL, Anderson JS, Bigler ED, Miller JS, Lange NT, Dubray MB, Cooperrider JR, Cariello A, Nielsen JA, Lainhart JE. (2012) Intact Prototype Formation but Impaired Generalization in Autism. Research in Autism Spectrum Disorders. Spring;6(2):921-930.

Anderson JS, Druzgal TJ, Froehlich A, DuBray MB, Lange N, Alexander AL, Abildskov T, Nielsen JA, Cariello AN, Cooperrider JR, Bigler ED, Lainhart JE. (2011) Decreased interhemispheric functional connectivity in autism. Cerebral Cortex. May;21(5):1134-46.

Anderson JS, Nielsen JA, Froehlich AL, DuBray MB, Druzgal TJ, Cariello AN, Cooperrider JR, Zielinski BA, Ravichandran C, Fletcher PT, Alexander AL, Bigler ED, Lange N, Lainhart JE. (2011) Functional connectivity magnetic resonance imaging classification of autism. Brain. 134(Pt 12):3742-54.

Southwick JS, Bigler ED, Froehlich A, Dubray MB, Alexander AL, Lange N, Lainhart JE. (2011) Memory functioning in children and adolescents with autism. Neuropsychology. 25(6):702-10.

Lainhart JE, Lange N. (2011) Increased neuron number and head size in autism. JAMA. Nov 9;306(18):2031-2.

Lange N, Dubray MB, Lee JE, Froimowitz MP, Froehlich A, Adluru N, Wright B, Ravichandran C, Fletcher PT, Bigler ED, Alexander AL, Lainhart JE. (2010) Atypical diffusion tensor hemispheric asymmetry in autism. Autism Research. 3(6):350-8.