Andrew Alexander

Andrew Alexander, PhD

PhD, University of Arizona, Tucson
Faculty Co-Director, Brain Imaging Core
Professor, Medical Physics and Psychiatry
Director of MRI Physics Research, Waisman Laboratory for Brain Imaging and Behavior

Contact Information:

Waisman Center
1500 Highland Avenue
Room T135
Madison, WI 53705
Lab Website: Waisman Laboratory for Brain Imaging and Behavior

Research Statement

My research is focused on the use of Magnetic Resonance Imaging (MRI) for mapping and measuring the functional and structural organization of the human brain. These techniques are being used to investigate the brain in both typically developing individuals and subjects with developmental disorders including autism. Functional MRI (fMRI) is used to assess brain regions associated with cognition and affect and their dysfunctions in these populations. Diffusion tensor MRI (DT-MRI) is being used to study the patterns of structural connectivity between brain activity regions. Anatomic imaging methods are used to assess longitudinal structural changes in brain regions. These measurements are ultimately compared with measures of affect, behavior and cognition in specific population groups.

Representative Publications

Merluzzi AP, Dean DC 3rd, Adluru N, Suryawanshi GS, Okonkwo OC, Oh JM, Hermann BP, Sager MA, Asthana S, Zhang H, Johnson SC, Alexander AL, Bendlin BB. (2016) Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging. Neurobiology of Aging. 43:79-88. doi: 10.1016/j.neurobiolaging.2016.03.026.

Dean DC 3rd, Hurley SA, Kecskemeti SR, O'Grady JP, Canda C, Davenport-Sis NJ, Carlsson CM, Zetterberg H, Blennow K, Asthana S, Sager MA, Johnson SC, Alexander AL, Bendlin BB. (2016) Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease. JAMA Neurology. In press.

Dean DC 3rd, Travers BG, Adluru N, Tromp do PM, Destiche DJ, Samsin D, Prigge MB, Zielinski BA, Fletcher PT, Anderson JS, Froehlich AL, Bigler ED, Lange N, Lainhart JE, Alexander AL. (2016) Investigating the Microstructural Correlation of White Matter in Autism Spectrum Disorder. Brain Connectivity. 6(5):415-33. doi: 10.1089/brain.2015.0385.

Dean DC 3rd, Sojkova J, Hurley S, Kecskemeti S, Okonkwo O, Bendlin BB, Theisen F, Johnson SC, Alexander AL, Gallagher CL. (2016) Alterations of Myelin Content in Parkinson's Disease: A Cross-Sectional Neuroimaging Study. PLoS One. 5;11(10):e0163774. doi: 10.1371/journal.pone.0163774.

Jantz PB, Bigler ED, Froehlich AL, Prigge MB, Cariello AN, Travers BG, Anderson J, Zielinski BA, Alexander AL, Lange N, Lainhart JE. (2015) Wide range achievement test in autism spectrum disorder: test-retest stability. Psychological Reports. 116(3):674-84. doi: 10.2466/03.15.PR0.116k24w8.

Pasha Hosseinbor A, Chung MK, Koay CG, Schaefer SM, van Reekum CM, Schmitz LP, Sutterer M, Alexander AL, Davidson RJ. (2015) 4D hyperspherical harmonic (HyperSPHARM) representation of surface anatomy: A holistic treatment of multiple disconnected anatomical structures. Medical Image Analysis. 22(1):89-101. doi: 10.1016/

Fox AS, Oler JA, Shackman AJ, Shelton SE, Raveendran M, McKay DR, Converse AK, Alexander A, Davidson RJ, Blangero J, Rogers J, Kalin NH. (2015) Intergenerational neural mediators of early-life anxious temperament. Proceedings of the National Academy of Sciences USA. 21;112(29):9118-22. doi: 10.1073/pnas.1508593112.

Nielsen JA, Zielinski BA, Fletcher PT, Alexander AL, Lange N, Bigler ED, Lainhart JE, Anderson JS. (2014) Abnormal lateralization of functional connectivity between language and default mode regions in autism. Molecular Autism. 6;5(1):8. doi: 10.1186/2040-2392-5-8.

Travers BG, Bigler ED, Tromp DPM, Adluru N, Froehlich AL, Ennis C, Lange N, Nielsen JA, Prigge MB, Alexander AL, Lainhart JE. (2014) Longitudinal processing speed impairments in males with autism and the effects of white matter microstructureLongitudinal processing speed impairments in males with autism and the effects of white matter microstructure. Neuropsychologia. Neuropsychologia, 53, 137-145.

Birn RM, Shackman AJ, Oler JA, Williams LE, McFarlin DR, Rogers GM, Shelton SE, Alexander AL, Pine DS, Slattery MJ, Davidson RJ, Fox AS, Kalin NH. (2014) Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety. Molecular Psychiatry. 19(8):915-22.

Zielinski BA, Prigge MB, Nielsen JA, Froehlich AL, Abildskov TJ, Anderson JS, Fletcher PT, Zygmunt KM, Travers BG, Lange N, Alexander AL, Bigler ED, Lainhart JE. (2014) Longitudinal changes in cortical thickness in autism and typical development. Brain. 137(Pt 6):1799-812.

Birn RM, Shackman AJ, Oler JA, Williams LE, McFarlin DR, Rogers GM, Shelton SE, Alexander AL, Pine DS, Slattery MJ, Davidson RJ, Fox AS, Kalin NH. (2014) Extreme early-life anxiety is associated with an evolutionarily conserved reduction in the strength of intrinsic functional connectivity between the dorsolateral prefrontal cortex and the central nucleus of the amygdala. Molecular Psychiatry. 19(8):853.

Hanson JL, Adluru N, Chung MK, Alexander AL, Davidson RJ, Pollak SD. (2013) Early Neglect Is Associated With Alterations in White Matter Integrity and Cognitive Functioning. Child Development. 84(5):1566-78.

Trontel HG, Duffield TC, Bigler ED, Froehlich A, Prigge MB, Nielsen JA, Cooperrider JR, Cariello AN, Travers BG, Anderson JS, Zielinski BA, Alexander A, Lange N, Lainhart JE. (2013) Fusiform correlates of facial memory in autism. Behavioral Sciences. 3(3):348-71. doi: 10.3390/bs3030348.

Nielsen JA, Zielinski BA, Fletcher PT, Alexander AL, Lange N, Bigler ED, Lainhart JE, Anderson JS. (2013) Multisite functional connectivity MRI classification of autism: ABIDE results. Frontiers in Human Neuroscience. 25;7:599. doi: 10.3389/fnhum.2013.00599.

Adluru N, Hanlon BM, Lutz A, Lainhart JE, Alexander AL, Davidson RJ. (2013) Penalized Likelihood Phenotyping: Unifying Voxelwise Analyses and Multi-Voxel Pattern Analyses in Neuroimaging. Neuroinformatics. 11(2):227-47.

Prigge MB, Lange N, Bigler ED, Merkley TL, Neeley ES, Abildskov TJ, Froehlich AL, Nielsen JA, Cooperrider JR, Cariello AN, Ravichandran C, Alexander AL, Lainhart JE. (2013) Corpus Callosum Area in Children and Adults with Autism. Research in Autism Spectrum Disorders. 7(2):221-234.

Gallagher C, Bell B, Bendlin B, Palotti M, Okonkwo O, Sodhi A, Wong R, Buyan-Dent L, Johnson S, Wilette A, Harding S, Ninman N, Kastman E, Alexander A. (2013) White Matter Microstructural Integrity and Executive Function in Parkinson's Disease. Journal of the International Neuropsychological Society. 19(3):349-54.

Tromp DP, Grupe DW, Oathes DJ, McFarlin DR, Hernandez PJ, Kral TR, Lee JE, Adams M, Alexander AL, Nitschke JB. (2012) Reduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorder. Archives of General Psychiatry. 69(9):925-34.

Hosseinbor AP, Chung MK, Wu YC, Fleming JO, Field AS, Alexander AL. (2012) Extracting quantitative measures from EAP: a small clinical study using BFOR. Medical Image Computing and Computer-Assisted Intervention. 15(Pt 2):280-7.

Travers BG, Adluru N, Ennis C, Tromp do PM, Destiche D, Doran S, Bigler ED, Lange N, Lainhart JE, Alexander AL. (2012) Diffusion tensor imaging in autism spectrum disorder: a review. Autism Research. 5(5):289-313.

Zielinski BA, Anderson JS, Froehlich AL, Prigge MB, Nielsen JA, Cooperrider JR, Cariello AN, Fletcher PT, Alexander AL, Lange N, Bigler ED, Lainhart JE. (2012) scMRI reveals large-scale brain network abnormalities in autism. PLoS One. 7(11):e49172.

Nacewicz BM, Angelos L, Dalton KM, Fischer R, Anderle MJ, Alexander AL, Davidson RJ. (2012) Reliable non-invasive measurement of human neurochemistry using proton spectroscopy with an anatomically defined amygdala-specific voxel. Neuroimage. 1;59(3):2548-59.

Southwick JS, Bigler ED, Froehlich A, Dubray MB, Alexander AL, Lange N, Lainhart JE. (2011) Memory functioning in children and adolescents with autism. Neuropsychology. 25(6):702-10.

Anderson JS, Druzgal TJ, Froehlich A, DuBray MB, Lange N, Alexander AL, Abildskov T, Nielsen JA, Cariello AN, Cooperrider JR, Bigler ED, Lainhart JE. (2011) Decreased interhemispheric functional connectivity in autism. Cerebral Cortex. May;21(5):1134-46.

Anderson JS, Nielsen JA, Froehlich AL, DuBray MB, Druzgal TJ, Cariello AN, Cooperrider JR, Zielinski BA, Ravichandran C, Fletcher PT, Alexander AL, Bigler ED, Lange N, Lainhart JE. (2011) Functional connectivity magnetic resonance imaging classification of autism. Brain. 134(Pt 12):3742-54.

Lange N, Dubray MB, Lee JE, Froimowitz MP, Froehlich A, Adluru N, Wright B, Ravichandran C, Fletcher PT, Bigler ED, Alexander AL, Lainhart JE. (2010) Atypical diffusion tensor hemispheric asymmetry in autism. Autism Research. 3(6):350-8.

Lee JE, Chung MK, Lazar M, DuBray MB, Kim J, Bigler ED, Lainhart JE, Alexander AL. (2009) A study of diffusion tensor imaging by tissue-specific, smoothing-compensated voxel-based analysis. Neuroimage. 1;44(3):870-83.

Jung Y, Samsonov AA, Block WF, Lazar M, Lu A, Liu J, Alexander AL. (2009) 3D diffusion tensor MRI with isotropic resolution using a steady-state radial acquisition. Journal of Magnetic Resonance Imaging. 29(5):1175-84.

Bendlin BB, Ries ML, Lazar M, Alexander AL, Dempsey RJ, Rowley HA, Sherman JE, Johnson SC. (2008) Longitudinal changes in patients with traumatic brain injury assessed with diffusion-tensor and volumetric imaging. Neuroimage. 15;42(2):503-14.

Ferrarelli F, Massimini M, Peterson MJ, Riedner BA, Lazar M, Murphy MJ, Huber R, Rosanova M, Alexander AL, Kalin N, Tononi G. (2008) Reduced evoked gamma oscillations in the frontal cortex in schizophrenia patients: a TMS/EEG study. American Journal of Psychiatry. 165(8):996-1005.

Wu YC, Field AS, Alexander AL. (2008) Computation of diffusion function measures in q-space using magnetic resonance hybrid diffusion imaging. IEEE Transactions on Medical Imaging. 27(6):858-65.