Murray Brilliant

Murray Brilliant, PhD

PhD, University of Colorado
Faculty Core Co-Director, Clinical Translational Core
Clinical Adjunct Professor, Genetics

Contact Information:

Waisman Center
1500 Highland Avenue
Room 653
Madison, WI 53705

Research Statement

Dr. Brilliant received his Ph.D. in Molecular, Cellular and Developmental Biology from the University of Colorado at Boulder in 1984. He has held faculty positions at The Jackson Laboratory in Bar Harbor, Maine (1986-1989), The Fox Chase Cancer Center in Philadelphia, Pennsylvania (1989-1997) and the University of Arizona College of Medicine (1997-2009) where he was the Lindholm Professor of Genetics in the Department of Pediatrics at the University of Arizona College of Medicine and Director of the Interdisciplinary Graduate Program in Genetics. Dr. Brilliant has 25 years of experience in the molecular genetics of mice and humans. In particular, his efforts have led to the identification of three genes for albinism: Hermansky-Pudlak syndrome 1 and Oculocutaneous albinism types 2 and 4.

His current research interest include:

  • The relationship between albinism and leprosy
  • Development of treatments to improve vision in people with albinism
  • Early detection and prevention of Age-related Macular Degeneration
  • Genetic Services disparities among Native Americans

Representative Publications

Adamsheck HC, Petty EM, Hong J, Baker MW, Brilliant MH, Mailick MR. (2017) Is Low FMR1 CGG Repeat Length in Males Correlated with Family History of BRCA-Associated Cancers? An Exploratory Analysis of Medical Records. Journal of Genetic Counseling. In Press.

Shukla SK, Murali NS, Brilliant MH. (2015) Personalized medicine going precise: from genomics to microbiomics. Trends in Molecular Medicine. 21(8):461-2. doi: 10.1016/j.molmed.2015.06.002.

Schrodi SJ, DeBarber A, He M, Ye Z, Peissig P, Van Wormer JJ, Haws R, Brilliant MH, Steiner RD. (2015) Prevalence estimation for monogenic autosomal recessive diseases using population-based genetic data. Human Genetics. 134(6):659-69. doi: 10.1007/s00439-015-1551-8.

Brilliant MH, Vaziri K, Connor TB Jr, Schwartz SG, Carroll JJ, McCarty CA, Schrodi SJ, Hebbring SJ, Kishor KS, Flynn HW Jr, Moshfeghi AA, Moshfeghi DM, Fini ME, McKay BS. (2015) Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration. American Journal of Medicine. In Press.

He M, Person TN, Hebbring SJ, Heinzen E, Ye Z, Schrodi SJ, McPherson EW, Lin SM, Peissig PL, Brilliant MH, O'Rawe J, Robison RJ, Lyon GJ, Wang K. (2015) SeqHBase: a big data toolset for family based sequencing data analysis. Journal of Medical Genetics. 52(4):282-8. doi: 10.1136/jmedgenet-2014-102907.

Ye Z, Mayer J, Ivacic L, Zhou Z, He M, Schrodi SJ, Page D, Brilliant MH, Hebbring SJ. (2015) Phenome-wide association studies (PheWASs) for functional variants. European Journal of Human Genetics. 23(4):523-9. doi: 10.1038/ejhg.2014.123.