Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Title: Suppression of microglia activation after hypoxia-ischemia results in age-dependent improvements in neurologic injury. Legend: P9 and P30 mice were exposed to unilateral hypoxia-ischemia and treated with minocycline or vehicle. A, B. Double immunohistological staining for Iba1 (green) and MAP2 (red) proteins in the CA1 region of the hippocampus at 2 days post-HI is shown. …
A team of eye researchers at the University of Wisconsin-Madison have used a custom stem cell model of a rare but blinding eye disease to test whether a commonly used drug might offer hope for treatment.
Legend: Latent growth curve modeling of longitudinal data (age 2-5 years) for 129 young children with ASD revealed four severity trajectory classes based on calibrated severity scores from the Autism Diagnostic Observation Schedule (ADOS): Persistent High (n=47); Persistent Moderate (n=54), Worsening (n=10), and Improving (n=18). The dashed line indicates the mean trajectory within each class. …
Legend: Fig. 1. The tokens of the determiner the for the three item types. Note the canonical formant transitions for the facilitating tokens and the steady formant values in the neutral token. Fig. 2. Proportion looking to target from onset of the to 1250 ms after target-word onset in the two conditions. Symbols and error bars …
Citation: Inter-pregnancy intervals and the risk of autism spectrum disorder: results of a population-based study. Durkin MS, DuBois LA, Maenner MJ, Journal of Autism and Developmental Disorders, 2015; 45(7): 2056-66. Abstract: Recent studies have reported an increased risk of autism among second-born children conceived <12 months versus >36 months after the birth of a sibling. …
