Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Neuropathology of the Down syndrome cerebral cortex includes fewer interneurons in upper cortical layers.
Picture a crisp October morning in Madison, Wisconsin – the bright colors of fall leaves, mists over the blue waters of Lake Mendota and – on one Sunday (the 14th this year) – a crowd of excited people waiting to run, walk or roll in the 2018 Waisman Whirl for ALL Abilities!
To test the hypothesis that cognitively unimpaired individuals with Alzheimer disease (AD) neuropathology differ from individuals with AD dementia on biomarkers of neurodegeneration, synaptic dysfunction, and glial activation.
Title: Associations of prenatal maternal depression and anxiety symptoms with infant white matter microstructure Legend: Decreased frontal neurite density in the prefrontal white matter (blue highlighted regions) of 1-month old infants was associated with higher prenatal maternal depression and anxiety. Advanced diffusion MRI brain scans were performed on 101 infants at the Waisman Center for this …
In 1998, UW–Madison developmental biologist James Thomson introduced the world to the first laboratory-derived human embryonic stem cells. Twenty years later, UW–Madison remains at the forefront of stem cell research. The Waisman Center at UW-Madison is a hub of stem cell research, especially in the fields of human development, developmental disabilities and neurodegerative disorders. You …
Research by Waisman affiliate Jon Audhya shows new insight into the molecular basis underlying the neurodegenerative condition, hereditary spastic paraplegia (HPS). His recent study shows how a mutation in the TFG gene–one of several linked to HPS–impairs neurons from forming structures needed to transmit signals properly. Read the full article, please visit https://www.med.wisc.edu/news-and-events/2018/september/nerve-cell-protein-factory/
