“Assembling Tridimensional Brain Models to Study Human Development and Disease”

Pasca’s lab is interested in deciphering the molecular and cellular mechanisms of neuropsychiatric disorders. To achieve this, they employ a multidisciplinary approach involving human genetics, molecular and developmental neurobiology, rodent disease models and neural cells differentiated from patient-derived induced pluripotent stem cells. They are also developing methods for generating specific classes of neurons from human stem cells and state-of-the-art tools for probing disease-relevant cellular endophenotypes. Their ultimate objective is to identify novel and reliable drug targets for neuropsychiatric disorders.