Waisman Center
Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

Bhattacharyya, PhD, A., and X. Zhao, PhD. CRISPR/Cas9 Editing of APP C-Terminus Attenuates β-Cleavage and Promotes α-Cleavage.

Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. (2019). CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage.  Nature Communications, 3;10(1):53. doi: 10.1038/s41467-018-07971-8.