University of Wisconsin–Madison

Jon Levine, PhD

Professor, Neuroscience

Jon Levine, PhD

PhD, University of Illinois, Urbana
Director, Wisconsin National Primate Research Center

Contact Information

1220 Capitol Court
Madison, WI 53715-1299
608.263.3500
levine@primate.wisc.edu

Research Statement

The goal of my NICHD-funded research is to investigate the cellular and molecular mechanisms that mediate the physiological feedback actions of estrogens in the brain. For the past 30 years I have studied the neuroendocrine regulation of gonadotropin releasing hormone (GnRH) neurons, in part by developing and utilizing physiological methods to monitor and analyze GnRH neurosecretion in awake animals. My research has also focused on the mechanisms by which ovarian steroids exert their effects in the brain, the latter including the negative feedback mechanisms that maintain homeostatic control within the reproductive axis, as well as the positive feedback actions of steroids that culminate in release of preovulatory gonadotropin surges. My recent work has made use of newly developed mutant mice to analyze the cell signaling mechanisms that mediate negative and positive feedback actions of estradiol. These recent research findings have provided new evidence for distinct “classical” transcriptional pathways, as well as “non-classical” genotropic and non-genotropic pathways, that contribute very differently to the manifestation of estradiol’s different feedback effects and metabolic neuroendocrine actions.

Selected Publications