Dolan Lecture – Laura Ranum, PhD – “RAN Translation in Neurologic Disease”

Dr. Ranum began her research career in human molecular genetics in 1989 at the University of Minnesota and is currently the Founding Director of the Center for NeuroGenetics and Professor of Molecular Genetics and Microbiology at the University of Florida. Over the past 25 years her laboratory has identified the mutations for a number of neurological disorders including spinocerebellar ataxia types 5 and 8 (SCA5, SCA8), and myotonic dystrophy type 2 (DM2). Her laboratory has developed and uses mouse models to understand how these and other mutations cause disease. Most recently, the Ranum lab created a mouse model of the C9orf72 ALS/dementia mutation that has generated wide interest in the scientific community studying ALS.