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John D. Wiley Conference Center

April 2019

Seminar – Fraser Sim, PhD – “Overcoming Obstacles Limiting Human Oligodendrocyte Progenitor Recruitment and Differentiation in the Demyelinated Brain”

April 19 @ 12:00 pm - 1:00 pm

About the Speaker: My lab investigates the molecular control of cell fate and homeostasis of resident stem and progenitor cells in the human brain. Using a combination of multicolor cell sorting techniques and whole genome analysis, we are characterizing the signaling pathways which regulate the formation and fate of human oligodendrocyte progenitor cells. We are testing the functional significance of these pathways using both pharmacological and viral methods in culture and animal-based models of myelination and demyelination.

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Waisman Lecture – Mustafa Sahin, MD, PhD – “Mechanism-Based Biomarker and Treatment Trials in Tuberous Sclerosis”

April 26 @ 12:00 pm - 1:00 pm

Mustafa Sahin is a developmental neurobiologist and a pediatric neurologist at Boston Children’s Hospital and Harvard Medical School. He received his Sc.B. degree from Brown University, his M.D. and Ph.D. from Yale School of Medicine. He completed a pediatrics residency at Children’s Hospital of Philadelphia and a child neurology residency at Boston Children’s Hospital. Sahin is a Professor at Harvard Medical school and the Rosamund Stone Zander Chair at Boston Children’s Hospital. At Boston Children’s, Sahin is the Director of the Translational Research Program and the Translational Neuroscience Center. Sahin has established and directs the Multidisciplinary Tuberous Sclerosis Program at Boston Children’s Hospital. Work in his lab has identified the mechanisms by which tuberous sclerosis leads to miswiring of neurons in the brain and potential therapies for this disorder. The lab uses a combination of human neurons in culture, animal models and clinical studies and has generated several lines of evidence showing that TSC/mTOR pathway plays crucial roles in axon specification, guidance, myelination and regeneration. Current research focuses on translating these preclinical findings into the clinic and developing treatments for epilepsy and autism associated with activation of the mTOR pathway. He directs two national consortia to study biomarkers and comparative pathobiology of TSC and related neurodevelopmental disorders.

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September 2019

Seminar – Kapil Bharti, PhD – Topic: Using Pluripotent Stem Cells to Study Mechanism and Develop Treatment for Eye Diseases

September 20 @ 12:00 pm

Kapil Bharti, PhD National Eye Institute, National Institutes of Health   For Further Information: Contact Teresa Palumbo at 608.263.5837 or palumbo@waisman.wisc.edu The seminar series is funded by the John D. Wiley Conference Center Fund, the…

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February 2020

Seminar – Chad Pearson, PhD – Topic: The Functions of Centrosome and Cilia and Their Implications in Human Diseases

February 14, 2020 @ 12:00 pm - 1:00 pm

Chad Pearson, PhD University of Colorado Anshcutz Medical Campus   For Further Information: Contact Teresa Palumbo at 608.263.5837 or palumbo@waisman.wisc.edu The seminar series is funded by the John D. Wiley Conference Center Fund, the Friends…

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