Aviad Hai, PhD

Position title: Vilas Early Career Associate Professor, Biomedical Engineering

PhD, Hebrew University of Jerusalem

Contact Information

Engineering Centers Building
1550 Engineering Dr
Room: 2112
Madison, WI 53706
(608) 890-3411
ahai@wisc.edu
Hai Lab

Research Statement

The Hai lab focuses on engineering minimally invasive tools to access the nervous system for neurobiological studies of brain function and neurological disorders. We develop electrical, magnetic and electromagnetic sensors for electrophysiology, and for wireless modalities such as functional Magnetic Resonance Imaging, magnetometry and more. We use nano-scale lithography and surface chemistry techniques and combine them with in vitro and in vivo neuroscience towards a broader understanding of the principles underlying neural network activity.

Selected Publications

Pubmed

Gokhale, Y., Coventry, B. S., Rogers, T., Lines, M., Vena, A., Phillips, J., Zhu, T., Bok, I., Troche, D., Glodowski, M., Vareberg, A., Bhatt, S., Ashtiani, A. O., Eliceiri, K. W., & Hai, A. (2025). Self-Aligned Multilayered Nitrogen Vacancy Diamond Nanoparticles for High Spatial Resolution Magnetometry of Microelectronic Currents. Nano letters, 25(23), 9204–9213. https://doi.org/10.1021/acs.nanolett.5c00656
Ren, X., Sirois, C. L., Doudlah, R., Mendez-Albelo, N. M., Hai, A., Rosenberg, A., & Zhao, X. (2025). A Semi-Automated MEA Spike sorting (SAMS) method for high throughput assessment of cultured neurons. bioRxiv : the preprint server for biology, 2025.02.08.637245. https://doi.org/10.1101/2025.02.08.637245
Bok, I., Phillips, J., Zhu, T., Lu, J., Detienne, E., Lima, E. A., Weiss, B. P., Jasanoff, A., & Hai, A. (2024). Magnetic Detection of Neural Activity by Nanocoil Transducers. Nano letters, 24(42), 13147–13152. https://doi.org/10.1021/acs.nanolett.4c02784
Vareberg, A. D., Bok, I., Eizadi, J., Ren, X., & Hai, A. (2024). Inference of network connectivity from temporally binned spike trains. Journal of neuroscience methods, 404, 110073. https://doi.org/10.1016/j.jneumeth.2024.110073
Bok, I., Ashtiani, A., Gokhale, Y., Phillips, J., Zhu, T., & Hai, A. (2024). Nanofabricated high turn-density spiral coils for on-chip electromagneto-optical conversion. Microsystems & nanoengineering, 10, 44. https://doi.org/10.1038/s41378-024-00674-9
Bok, I., Rauch, B., Ashtiani, A., & Hai, A. (2024). Direct observation of NMR transverse relaxation in nanopatterned clusters of iron oxide particles. Magnetic resonance in medicine, 91(2), 687–698. https://doi.org/10.1002/mrm.29898
Bok, I., Vareberg, A., Gokhale, Y., Bhatt, S., Masterson, E., Phillips, J., Zhu, T., Ren, X., & Hai, A. (2023). Wireless agents for brain recording and stimulation modalities. Bioelectronic medicine, 9(1), 20. https://doi.org/10.1186/s42234-023-00122-5
Ren, X., Bok, I., Vareberg, A., & Hai, A. (2023). Stimulation-mediated reverse engineering of silent neural networks. Journal of neurophysiology, 129(6), 1505–1514. https://doi.org/10.1152/jn.00100.2023
Bhatt, S., Masterson, E., Zhu, T., Eizadi, J., George, J., Graupe, N., Vareberg, A., Phillips, J., Bok, I., Dwyer, M., Ashtiani, A., & Hai, A. (2023). Wireless in vivo Recording of Cortical Activity by an Ion-Sensitive Field Effect Transistor. Sensors and actuators. B, Chemical, 382, 133549. https://doi.org/10.1016/j.snb.2023.133549
Phillips, J., Glodowski, M., Gokhale, Y., Dwyer, M., Ashtiani, A., & Hai, A. (2022). Enhanced magnetic transduction of neuronal activity by nanofabricated inductors quantified via finite element analysis. Journal of Neural Engineering, 19(4), 10.1088/1741-2552/ac7907. https://doi.org/10.1088/1741-2552/ac7907
Bok, I., Haber, I., Qu, X., & Hai, A. (2022). In silico assessment of electrophysiological neuronal recordings mediated by magnetoelectric nanoparticles. Scientific reports, 12(1), 8386. https://doi.org/10.1038/s41598-022-12303-4
Bricault S, Barandov A, Harvey P, DeTienne E, Hai A, Jasanoff A. (2020). Image-guided neural activity manipulation with a paramagnetic drug. Nature Communications, 11(1):136.
Hai A, Spanoudaki V, Bartelle BB, Jasanoff A. (2019). Wireless resonant circuits for the minimally invasive sensing of biophysical processes in magnetic resonance imaging. Nature Biomedical Engineering, 3, 69-78.
Hai A, Lee T, Cai LX, Lelyveld VS, Jasanoff A. (2016). Molecular fMRI of Serotonin transport. Neuron 9, 1-12.
Hai A, Jasanoff A. (2015). Molecular fMRI. Brain Mapping: An Encyclopedic Reference 1: 123-129
Lee T, Cai LX, Lelyveld VS, Hai A, Jasanoff A. (2014). Molecular-level functional magnetic resonance imaging of dopaminergic signaling. Science 344(6183):533-5.
Spira, ME, Hai, A. (2013). Multi-electrode array technologies for neuroscience and cardiology. Nature Nanotechnology, 8, 83-94.
Hai A, Shappir J, Spira ME. (2010). In-cell recordings by extracellular microelectrodes. Nature Methods, 7(3):200-202.