Slide of the Week

  • Randolph Ashton, PhD - Slide of the Week

    Randolph Ashton, PhD – Slide of the Week

    The spinal cord contains billions of neurons, with a huge diversity of subtypes enabling sensory, proprioceptive, and motor function.  However, current human stem cell-based in vitro models and prospective cell transplantation therapies fail to reflect the significant regional specificity of spinal cells. 

  • Xinyu Zhao, PhD - Slide of the Week

    Xinyu Zhao, PhD – Slide of the Week

    Voluntary running enhances adult hippocampal neurogenesis, with consequences for hippocampal-dependent learning ability and mood regulation. However, the underlying mechanism remains unclear. Here, we show that voluntary running induces unique and dynamic gene expression changes specifically within the adult-born hippocampal neurons, with significant impact on genes involved in neuronal maturation and human diseases. We identify the regulator of G protein signaling 6 (RGS6) as a key factor that mediates running impact on adult-born neurons.

  • Donna Werling, PhD - Slide of the Week

    Donna Werling, PhD – Slide of the Week

    Autism spectrum disorder (ASD) is consistently diagnosed 3 to 5 times more frequently in males than females, a dramatically sex-biased prevalence that suggests the involvement of sex-differential biological factors in modulating risk. The genomic scale of transcriptomic analyses of human brain tissue can provide an unbiased approach for identifying genes and associated functional processes at the intersection of sex-differential and ASD-impacted neurobiology.

  • Wang Slide of the Week

    Daifeng Wang, PhD – Slide of the Week

    Understanding cell-type-specific gene regulatory mechanisms from genetic variants to diseases remains challenging. To address this, we developed a computational pipeline, scGRNom (single-cell Gene Regulatory Network prediction from multi-omics), to predict cell-type disease genes and regulatory networks including transcription factors and regulatory elements.

  • Houri K. Vorperian, PhD - Slide of the Week

    Houri K. Vorperian, PhD – Slide of the Week

    Title: Auditory-Perceptual Features of Speech in Children and Adults with Down syndrome: A Speech Profile Analysis Legend: Table 6 – Principal component loading matrix, first four principal components, vowel features. Note. The largest loadings (in …

  • Brittany G. Travers, PhD - Slide of the Week

    Brittany G. Travers, PhD – Slide of the Week

    Title: Associations among daily living skills, motor, and sensory difficulties in children with and without autism Legend: The goal of this study was to determine how motor skills relate to daily living skills in children 6-10 …

  • John Svaren, PhD – Slide of the Week

    Title: CRISPR-Cas9 deletion of PMP22 super enhancer creates  a new model of hereditary neuropathy with liability to pressure palsies (HNPP) Legend: (A) Morphometric analysis demonstrates axonal loss i thin section were taken from 3- to 5-month-old …

  • Audra Sterling, PhD - Slide of the Week

    Audra Sterling, PhD – Slide of the Week

    Autism spectrum disorder (ASD) and fragile X syndrome (FXS) are neurodevelopmental disorders with overlapping pragmatic language impairments. Prior work suggests pragmatic language differences may run in families. This study examined specific pragmatic difficulties (i.e., linguistic mazes and perseverations) in boys (9–18 years) with idiopathic ASD (n = 26) and FXS+ASD (n = 29), and relationships with maternal maze use.

  • André Sousa, PhD - Slide of the Week

    André Sousa, PhD – Slide of the Week

    Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering prenatal and postnatal rhesus macaque development.

  • Jenny Saffran, PhD - Slide of the Week

    Jenny Saffran, PhD – Slide of the Week

    How do learners gather new information during word learning? One possibility is that learners selectively sample items that help them reduce uncertainty about new word meanings.

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