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Waisman Center
Waisman Center
Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
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  1. Home
  2. Alexander Disease

Alexander Disease

Genotype-Phenotype Association for 14 GFAP Variants in Alexander Disease

GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease

Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander disease

Quantitative diffusion imaging and genotype-by-sex interactions in a rat model of Alexander disease

Large-scale gene expression changes in APP/PSEN1 and GFAP mutation models exhibit high congruence with Alzheimer’s disease

Alexander disease: The story behind an eponym

Anastasis Drives Senescence and Non-Cell Autonomous Neurodegeneration in the Astrogliopathy Alexander Disease

Alexander disease: models, mechanisms, and medicine

Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment

Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes

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