Alexander, PhD, Andrew

Dean, D. C., 3rd, Tisdall, M. D., Wisnowski, J. L., Feczko, E., Gagoski, B., Alexander, A. L., Edden, R. A. E., Gao, W., Hendrickson, T. J., Howell, B. R., Huang, H., Humphreys, K. L., Riggins, T., Sylvester, C. M., Weldon, K. B., Yacoub, E., Ahtam, B., Beck, N., Banerjee, S., Boroday, S., … HBCD MRI Working Group (2024). Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol. Developmental cognitive neuroscience, 70, 101452. https://doi.org/10.1016/j.dcn.2024.101452

Surgent, O., Guerrero-Gonzalez, J., Dean, D. C., 3rd, Adluru, N., Kirk, G. R., Kecskemeti, S. R., Alexander, A. L., Li, J. J., & Travers, B. G. (2024). Microstructural neural correlates of maximal grip strength in autistic children: the role of the cortico-cerebellar network and attention-deficit/hyperactivity disorder features. Frontiers in integrative neuroscience, 18, 1359099. https://doi.org/10.3389/fnint.2024.1359099

Guerrero-Gonzalez, J. M., Kirk, G. R., Birn, R., Bigler, E. D., Bowen, K., Broman, A. T., Rosario, B. L., Butt, W., Beers, S. R., Bell, M. J., Alexander, A. L., Ferrazzano, P. A., & ADAPT MRI Biomarkers Investigators (2024). Multi-modal MRI of hippocampal morphometry and connectivity after pediatric severe TBI. Brain imaging and behavior, 18(1), 159–170. https://doi.org/10.1007/s11682-023-00818-x

Travers, B. G., Surgent, O., Guerrero-Gonzalez, J., Dean, D. C., 3rd, Adluru, N., Kecskemeti, S. R., Kirk, G. R., Alexander, A. L., Zhu, J., Skaletski, E. C., Naik, S., & Duran, M. (2024). Role of autonomic, nociceptive, and limbic brainstem nuclei in core autism features. Autism research : official journal of the International Society for Autism Research, 17(2), 266–279. https://doi.org/10.1002/aur.3096

Peterson, M., Prigge, M. B. D., Floris, D. L., Bigler, E. D., Zielinski, B., King, J. B., Lange, N., Alexander, A. L., Lainhart, J. E., & Nielsen, J. A. (2023). Reduced Lateralization of Multiple Functional Brain Networks in Autistic Males. bioRxiv : the preprint server for biology, 2023.12.15.571928. https://doi.org/10.1101/2023.12.15.571928

Chung, M. K., Azizi, T., Hanson, J. L., Alexander, A. L., Davidson, R. J., & Pollak, S. D. (2023). Altered Topological Structure of the Brain White Matter in Maltreated Children through Topological Data Analysis. ArXiv, arXiv:2304.05908v3.

Chu, D. Y., Adluru, N., Nair, V. A., Choi, T., Adluru, A., Garcia-Ramos, C., Dabbs, K., Mathis, J., Nencka, A. S., Gundlach, C., Conant, L., Binder, J. R., Meyerand, M. E., Alexander, A. L., Struck, A. F., Hermann, B., & Prabhakaran, V. (2023). Association of neighborhood deprivation with white matter connectome abnormalities in temporal lobe epilepsy. Epilepsia, 64(9), 2484–2498. https://doi.org/10.1111/epi.17702

DiPiero, M., Cordash, H., Prigge, M. B., King, C. K., Morgan, J., Guerrero-Gonzalez, J., Adluru, N., King, J. B., Lange, N., Bigler, E. D., Zielinski, B. A., Alexander, A. L., Lainhart, J. E., & Dean, D. C., 3rd (2023). Tract- and gray matter- based spatial statistics show white matter and gray matter microstructural differences in autistic males. Frontiers in neuroscience, 17, 1231719. https://doi.org/10.3389/fnins.2023.1231719

Girard, G., Rafael-Patiño, J., Truffet, R., Aydogan, D. B., Adluru, N., Nair, V. A., Prabhakaran, V., Bendlin, B. B., Alexander, A. L., Bosticardo, S., Gabusi, I., Ocampo-Pineda, M., Battocchio, M., Piskorova, Z., Bontempi, P., Schiavi, S., Daducci, A., Stafiej, A., Ciupek, D., Bogusz, F., … Thiran, J. P. (2023). Tractography passes the test: results from the diffusion-simulated connectivity (DiSCo) challenge. NeuroImage, 277, 120231. https://doi.org/10.1016/j.neuroimage.2023.120231

Surgent, O., Guerrero-Gonzalez, J., Dean, D. C., 3rd, Kirk, G. R., Adluru, N., Kecskemeti, S. R., Alexander, A. L., & Travers, B. G. (2023). How we get a grip: Microstructural neural correlates of manual grip strength in children. NeuroImage, 273, 120117. https://doi.org/10.1016/j.neuroimage.2023.120117

Garcia-Ramos, C., Adluru, N., Chu, D. Y., Nair, V., Adluru, A., Nencka, A., Maganti, R., Mathis, J., Conant, L. L., Alexander, A. L., Prabhakaran, V., Binder, J. R., Meyerand, M. E., Hermann, B., & Struck, A. F. (2023). Multi-shell connectome DWI-based graph theory measures for the prediction of temporal lobe epilepsy and cognition. Cerebral cortex (New York, N.Y. : 1991), 33(12), 8056–8065. https://doi.org/10.1093/cercor/bhad098

Planalp, E. M., Dowe, K. N., Alexander, A. L., Goldsmith, H. H., Davidson, R. J., & Dean, D. C., 3rd (2023). White matter microstructure predicts individual differences in infant fear (But not anger and sadness). Developmental Science, 26(3), e13340. https://doi.org/10.1111/desc.13340

DiPiero, M. A., Surgent, O. J., Travers, B. G., Alexander, A. L., Lainhart, J. E., & Dean Iii, D. C. (2023). Gray matter microstructure differences in autistic males: A gray matter based spatial statistics study. NeuroImage. Clinical, 37, 103306. https://doi.org/10.1016/j.nicl.2022.103306

Surgent, O., Riaz, A., Ausderau, K. K., Adluru, N., Kirk, G. R., Guerrero-Gonzalez, J., Skaletski, E. C., Kecskemeti, S. R., Dean Iii, D. C., Weismer, S. E., Alexander, A. L., & Travers, B. G. (2022). Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children. Molecular autism, 13(1), 48. https://doi.org/10.1186/s13229-022-00524-3

Moody, J. F., Dean, D. C., 3rd, Kecskemeti, S. R., Blennow, K., Zetterberg, H., Kollmorgen, G., Suridjan, I., Wild, N., Carlsson, C. M., Johnson, S. C., Alexander, A. L., & Bendlin, B. B. (2022). Associations between diffusion MRI microstructure and cerebrospinal fluid markers of Alzheimer’s disease pathology and neurodegeneration along the Alzheimer’s disease continuum. Alzheimer’s & dementia (Amsterdam, Netherlands), 14(1), e12381. https://doi.org/10.1002/dad2.12381

Guerrero-Gonzalez, J. M., Yeske, B., Kirk, G. R., Bell, M. J., Ferrazzano, P. A., & Alexander, A. L. (2022). Mahalanobis distance tractometry (MaD-Tract) – a framework for personalized white matter anomaly detection applied to TBI. NeuroImage, 260, 119475. https://doi.org/10.1016/j.neuroimage.2022.119475

Birn, R. M., Dean, D. C., 3rd, Wooten, W., Planalp, E. M., Kecskemeti, S., Alexander, A. L., Goldsmith, H. H., & Davidson, R. J. (2022). Reduction of motion artifacts in functional connectivity resulting from infrequent large motion. Brain Connectivity, 12(8), 740–753. https://doi.org/10.1089/brain.2021.0133

Prigge, M., Bigler, E. D., Lange, N., Morgan, J., Froehlich, A., Freeman, A., Kellett, K., Kane, K. L., King, C. K., Taylor, J., Dean, D. C., 3rd, King, J. B., Anderson, J. S., Zielinski, B. A., Alexander, A. L., & Lainhart, J. E. (2022). Longitudinal stability of intellectual functioning in autism spectrum disorder: From age 3 through mid-adulthood. Journal of Autism and Developmental Disorders, 52(10), 4490–4504. https://doi.org/10.1007/s10803-021-05227-x

Grupe, D. W., Barnes, A. L., Gresham, L., Kirvin-Quamme, A., Nord, E., Alexander, A. L., Abercrombie, H. C., Schaefer, S. M., & Davidson, R. J. (2022). Perceived stress associations with hippocampal-dependent behavior and hippocampal subfield volume. Neurobiology of Stress, 19, 100469. https://doi.org/10.1016/j.ynstr.2022.100469

Ferguson, N. M., Rebsamen, S., Field, A. S., Guerrero, J. M., Rosario, B. L., Broman, A. T., Rathouz, P. J., Bell, M. J., Alexander, A. L., Ferrazzano, P. A., & ADAPT MRI Investigators (2022). Magnetic Resonance Imaging Findings in Infants with Severe Traumatic Brain Injury and Associations with Abusive Head Trauma. Children (Basel, Switzerland), 9(7), 1092. https://doi.org/10.3390/children9071092

Knussmann, G. N., Anderson, J. S., Prigge, M., Dean, D. C., 3rd, Lange, N., Bigler, E. D., Alexander, A. L., Lainhart, J. E., Zielinski, B. A., & King, J. B. (2022). Test-retest reliability of FreeSurfer-derived volume, area and cortical thickness from MPRAGE and MP2RAGE brain MRI images. Neuroimage. Reports, 2(2), 100086. https://doi.org/10.1016/j.ynirp.2022.100086

Moody, J. F., Aggarwal, N., Dean, D. C., 3rd, Tromp, D., Kecskemeti, S. R., Oler, J. A., Kalin, N. H., & Alexander, A. L. (2022). Longitudinal assessment of early-life white matter development with quantitative relaxometry in nonhuman primates. NeuroImage, 251, 118989. https://doi.org/10.1016/j.neuroimage.2022.118989

Guerrero-Gonzalez, J., Surgent, O., Adluru, N., Kirk, G. R., Dean Iii, D. C., Kecskemeti, S. R., Alexander, A. L., & Travers, B. G. (2022). Improving Imaging of the Brainstem and Cerebellum in Autistic Children: Transformation-Based High-Resolution Diffusion MRI (TiDi-Fused) in the Human Brainstem. Frontiers in integrative neuroscience, 16, 804743. https://doi.org/10.3389/fnint.2022.804743

Luo, Z., Adluru, N., Dean, D. C., 3rd, Alexander, A. L., & Goldsmith, H. H. (2022). Genetic and environmental influences of variation in diffusion MRI measures of white matter microstructure. Brain structure & function, 227(1), 131–144. https://doi.org/10.1007/s00429-021-02393-7

Bazydlo, A. M., Zammit, M. D., Wu, M., Lao, P. J., Dean, D. C., 3rd, Johnson, S. C., Tudorascu, D. L., Cohen, A., Cody, K. A., Ances, B., Laymon, C. M., Klunk, W. E., Zaman, S., Handen, B. L., Hartley, S. L., Alexander, A. L., & Christian, B. T. (2022). White matter microstructure associations to amyloid burden in adults with Down syndrome. NeuroImage. Clinical, 33, 102908. https://doi.org/10.1016/j.nicl.2021.102908

Vogt, N. M., Hunt, J., Adluru, N., Ma, Y., Van Hulle, C. A., Doug III, D., Kecskemeti, S. R., Chin, N. A., Carlsson, C. M., Asthana, S., Johnson, S. C., Kollmorgen, G., Batrla, R., Wild, N., Buck, K., Zetterberg, H., Alexander, A. L., Blennow, K., & Bendlin, B. B. (2022). Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults. Alzheimer’s & dementia: the journal of the Alzheimer’s Association, 18(1):65-76. doi: 10.1002/alz.12364.

Zhou, X., Planalp, E. M., Heinrich, L., Pletcher, C., DiPiero, M., Alexander, A. L., Litovsky, R. Y., & Dean, D. C., 3rd (2022). Inhibitory Control in Children 4-10 Years of Age: Evidence From Functional Near-Infrared Spectroscopy Task-Based Observations. Frontiers in human neuroscience, 15, 798358. DOI: 10.3389/fnhum.2021.798358

Fleming, V., Piro-Gambetti, B., Patrick, A., Zammit, M., Alexander, A., Christian, B. T., Handen, B., Cohen, A., Klunk, W., Laymon, C., Ances, B. M., Plante, D. T., Okonkwo, O., & Hartley, S. L. (2021). Physical activity and cognitive and imaging biomarkers of Alzheimer’s disease in down syndrome. Neurobiology of aging, 107, 118–127. https://doi.org/10.1016/j.neurobiolaging.2021.07.016

Kecskemeti, S., Freeman, A., Travers, B. G., & Alexander, A. L. (2021). FreeSurfer based cortical mapping and T1-relaxometry with MPnRAGE: Test-retest reliability with and without retrospective motion correction. NeuroImage, 242, 118447. https://doi.org/10.1016/j.neuroimage.2021.118447

Peterson, M., Prigge, M., Bigler, E. D., Zielinski, B., King, J. B., Lange, N., Alexander, A., Lainhart, J. E., & Nielsen, J. A. (2021). Evidence for normal extra-axial cerebrospinal fluid volume in autistic males from middle childhood to adulthood. NeuroImage, 240, 118387. https://doi.org/10.1016/j.neuroimage.2021.118387

Fleming, V., Piro-Gambetti, B., Bazydlo, A., Zammit, M., Alexander, A. L., Christian, B. T., Handen, B., Plante, D. T., & Hartley, S. L. (2021). Sleep and White Matter in Adults with Down Syndrome. Brain sciences, 11(10), 1322. https://doi.org/10.3390/brainsci11101322

Moody, J. F., Adluru, N., Alexander, A. L., & Field, A. S. (2021). The Connectomes: Methods of White Matter Tractography and Contributions of Resting State fMRI. Seminars in ultrasound, CT, and MR, 42(5), 507–522. https://doi.org/10.1053/j.sult.2021.07.007

Prigge, M., Lange, N., Bigler, E. D., King, J. B., Dean, D. C., 3rd, Adluru, N., Alexander, A. L., Lainhart, J. E., & Zielinski, B. A. (2021). A 16-year study of longitudinal volumetric brain development in males with autism. NeuroImage, 236, 118067. https://doi.org/10.1016/j.neuroimage.2021.118067

Ferrazzano, P., Yeske, B., Mumford, J., Kirk, G., Bigler, E. D., Bowen, K., O’Brien, N., Rosario, B., Beers, S. R., Rathouz, P., Bell, M. J., & Alexander, A. L. (2021). Brain Magnetic Resonance Imaging Volumetric Measures of Functional Outcome after Severe Traumatic Brain Injury in Adolescents. Journal of neurotrauma, 38(13), 1799–1808. https://doi.org/10.1089/neu.2019.6918

Surgent, O., Dean, D. C., Alexander, A. L., Dadalko, O. I., Guerrero-Gonzalez, J., Taylor, D., Skaletski, E., & Travers, B. G. (2021). Neurobiological and behavioural outcomes of biofeedback-based training in autism: a randomized controlled trial. Brain communications, 3(3), fcab112. https://doi.org/10.1093/braincomms/fcab112

HashemizadehKolowri, S. K., Chen, R. R., Adluru, G., Dean, D. C., Wilde, E. A., Alexander, A. L., & DiBella, E. (2021). Simultaneous multi-slice image reconstruction using regularized image domain split slice-GRAPPA for diffusion MRI. Medical image analysis, 70, 102000. https://doi.org/10.1016/j.media.2021.102000

Aggarwal, N., Moody, J. F., Dean, D. C., Tromp, D., Kecskemeti, S. R., Oler, J. A., Alexander, A. L., & Kalin, N. H. (2021). Spatiotemporal dynamics of nonhuman primate white matter development during the first year of life. NeuroImage, 231, 117825. https://doi.org/10.1016/j.neuroimage.2021.117825

Dowe, K. N., Planalp, E. M., Dean, D. C., 3rd, Alexander, A. L., Davidson, R. J., & Goldsmith, H. H. (2020). Early microstructure of white matter associated with infant attention. Developmental cognitive neuroscience, 45, 100815. https://doi.org/10.1016/j.dcn.2020.100815

Liu Y, Nacewicz BM, Zhao G, Adluru N, Kirk GR, Ferrazzano PA, Styner MA, Alexander AL. (2020) A 3D Fully Convolutional Neural Network With Top-Down Attention-Guided Refinement for Accurate and Robust Automatic Segmentation of Amygdala and Its Subnuclei. Frontiers in Neuroscience. 14:260. doi: 10.3389/fnins.2020.00260. PMID: 32508558; PMCID: PMC7253589.

Vogt NM, Hunt JF, Adluru N, Dean DC, Johnson SC, Asthana S, Yu JJ, Alexander AL, Bendlin BB. (2020). Cortical Microstructural Alterations in Mild Cognitive Impairment and Alzheimer’s Disease Dementia. Cerebral Cortex, 30(5):2948-2960. doi: 10.1093/cercor/bhz286.

Kecskemeti S, Alexander AL. (2020). Three-dimensional motion-corrected T₁ relaxometry with MPnRAGE. Magnetic Resonance in Medicine 2020 Apr 17. doi: 10.1002/mrm.28283. Epub ahead of print. PMID: 32301173.

Kecskemeti SR, Alexander AL. (2020). Test-retest of automated segmentation with different motion correction strategies: A comparison of prospective versus retrospective methods. Neuroimage. 2020 Apr 1;209:116494. doi: 10.1016/j.neuroimage.2019.116494. Epub 2019 Dec 30. PMID: 31899289; PMCID: PMC7056555.

Guerrero JM, Adluru N, Bendlin BB, Goldsmith HH, Schaefer SM, Davidson RJ, Kecskemeti SR, Zhang H, Alexander AL. (2019). Optimizing the intrinsic parallel diffusivity in NODDI: An extensive empirical evaluation. PLoS One. 14(9):e0217118. doi: 10.1371/journal.pone.0217118.

Green, R. R., Bigler, E. D., Froehlich, A., Prigge, M., Zielinski, B. A., Travers, B. G., Anderson, J. S., Alexander, A., Lange, N., & Lainhart, J. E. (2019). Beery VMI and Brain Volumetric Relations in Autism Spectrum Disorder. Journal of pediatric neuropsychology, 5(3), 77–84. https://doi.org/10.1007/s40817-019-00069-z

King JB, Prigge MBD, King CK, Morgan J, Weathersby F, Fox JC, Dean DC 3rd, Freeman A, Villaruz JAM, Kane KL, Bigler ED, Alexander AL, Lange N, Zielinski B, Lainhart JE, Anderson JS. (2019). Generalizability and reproducibility of functional connectivity in autism. Molecular Autism, 24;10:27. doi: 10.1186/s13229-019-0273-5.

Adluru N, Luo Z, Van Hulle CA, Schoen AJ, Davidson RJ, Alexander AL, Goldsmith HH. (2019). Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach. Science Reports, 18;7(1):8749. PMID: 28821748. PMCID: PMC5562810. DOI: 10.1038/s41598-017-08107-6

Birn RM, Converse AK, Rajala AZ, Alexander AL, Block WF, McMillan AB, Christian BT, Filla CN, Murali D, Hurley SA, Jenison RL, Populin LC. (2019). Changes in endogenous dopamine induced by methylphenidate predict functional connectivity in non-human primates. Journal of Neuroscience, 39(8):1436-1444. doi: 10.1523/JNEUROSCI.2513-18.2018.

Ferrazzano PA, Rosario BL, Wisniewski SR, Shafi NI, Siefkes HM, Miles DK, Alexander AL, Bell MJ; Investigators of the ADAPT Trial. (2019). Use of magnetic resonance imaging in severe pediatric traumatic brain injury: assessment of current practice. Journal of Neurosurgery Pediatrics, 8:1-9. doi: 10.3171/2018.10.PEDS18374.

Rowley PA, Guerrero-Gonzalez J, Alexander AL, Yu JJ. (2019). Convergent microstructural brain changes across genetic models of autism spectrum disorder-A pilot study. Psychiatry Research Neuroimaging, 30;283:83-91. doi: 10.1016/j.pscychresns.2018.12.007.

Kecskemeti S, Samsonov A, Velikina J, Field AS, Turski P, Rowley H, Lainhart JE, Alexander AL. (2018). Robust Motion Correction Strategy for Structural MRI in Unsedated Children Demonstrated with Three-dimensional Radial MPnRAGE. Radiology, 289(2):509-516. doi: 10.1148/radiol.2018180180. Epub 2018 Jul 31.

Pozorski V, Oh JM, Adluru N, Merluzzi AP, Theisen F, Okonkwo O, Barzgari A, Krislov S, Sojkova J, Bendlin BB, Johnson SC, Alexander AL, Gallagher CL. (2018). Longitudinal white matter microstructural change in Parkinson’s disease. Human Brain Mapping, 39(10):4150-4161. doi: 10.1002/hbm.24239.

Prigge MBD, Bigler ED, Travers BG, Froehlich A, Abildskov T, Anderson JS, Alexander AL, Lange N, Lainhart JE, Zielinski BA. (2018). Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 48(10):3319-3329. doi: 10.1007/s10803-018-3566-1.

Dean DC 3rd, Planalp EM, Wooten W, Kecskemeti SR, Adluru N, Schmidt CK, Frye C, Birn RM, Burghy CA, Schmidt NL, Styner MA, Short SJ, Kalin NH, Goldsmith HH, Alexander AL, Davidson RJ. (2019). Association of Prenatal Maternal Depression and Anxiety Symptoms With Infant White Matter Microstructure. JAMA Pediatrics, 172(10):973-981. PMID: 30177999. PMCID: PMC6190835. DOI: 10.1001/jamapediatrics.2018.2132

McLaughlin K, Travers BG, Dadalko OI, Dean DC 3rd, Tromp D, Adluru N, Destiche D, Freeman A, Prigge MD, Froehlich A, Duffield TC, Zielinski BA, Bigler ED, Lange N, Anderson JS, Alexander AL, Lainhart JE. (2018). Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder. Autism Research, 11(3):450-462.

Ong IM, Gonzalez JG, McIlwain SJ, Sawin EA, Schoen AJ, Adluru N, Alexander AL, Yu JJ. (2018). Gut microbiome populations are associated with structure-specific changes in white matter architecture. Translational Psychiatry. 8(1):6. doi: 10.1038/s41398-017-0022-5.

Dean DC 3rd, Planalp EM, Wooten W, Schmidt CK, Kecskemeti SR, Frye C, Schmidt NL, Goldsmith HH, Alexander AL, Davidson RJ. (2018). Investigation of brain structure in the 1-month infant. Brain Structure and Function, 223(4):1953-1970. doi: 10.1007/s00429-017-1600-2.

Van Riper SM, Alexander AL, Koltyn KF, Stegner AJ, Ellingson LD, Destiche DJ, Dougherty RJ, Lindheimer JB, Cook DB. (2017). Cerebral white matter structure is disrupted in Gulf War Veterans with chronic musculoskeletal pain. Pain, 158(12):2364-2375. doi: 10.1097/j.pain.0000000000001038

Lalani SJ, Duffield TC, Trontel HG, Bigler ED, Abildskov TJ, Froehlich A, Prigge MBD, Travers BG, Anderson JS, Zielinski BA, Alexander A, Lange N, Lainhart JE. (2017). Auditory attention in autism spectrum disorder: An exploration of volumetric magnetic resonance imaging findings. Journal of Clinical and Experimental Neuropsychology, 26:1-16.

Theisen F, Leda R, Pozorski V, Oh JM, Adluru N, Wong R, Okonkwo O, Dean DC 3rd, Bendlin BB, Johnson SC, Alexander AL, Gallagher CL. (2017). Evaluation of striatonigral connectivity using probabilistic tractography in Parkinson’s disease. Neuroimage Clinical, 9;16:557-563. doi: 10.1016/j.nicl.2017.09.009

Chung MK, Hanson JL, Adluru N, Alexander AL, Davidson RJ, Pollak SD. (2017). Integrative Structural Brain Network Analysis in Diffusion Tensor Imaging. Brain Connect, 7(6):331-346. doi: 10.1089/brain.2016.0481.

Travers BG, Bigler ED, Duffield TC, Prigge MDB, Froehlich AL, Lange N, Alexander AL, Lainhart JE. (2017). Longitudinal development of manual motor ability in autism spectrum disorder from childhood to mid-adulthood relates to adaptive daily living skills. Developmental Science, 20(4).

Oler JA, Tromp DP, Fox AS, Kovner R, Davidson RJ, Alexander AL, McFarlin DR, Birn RM, E Berg B, deCampo DM, Kalin NH, Fudge JL. (2017). Connectivity between the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the non-human primate: neuronal tract tracing and developmental neuroimaging studies. Brain Structure & Function, 222(1):21-39. doi: 10.1007/s00429-016-1198-9.

Dean DC 3rd, Lange N, Travers BG, Prigge MB, Matsunami N, Kellett KA, Freeman A, Kane KL, Adluru N, Tromp DP, Destiche DJ, Samsin D, Zielinski BA, Fletcher PT, Anderson JS, Froehlich AL, Leppert MF, Bigler ED, Lainhart JE, Alexander AL. (2017). Multivariate characterization of white matter heterogeneity in autism spectrum disorder. NeuroImage: Clinical, 6;14:54-66.

Dean DC 3rd, Hurley SA, Kecskemeti SR, O’Grady JP, Canda C, Davenport-Sis NJ, Carlsson CM, Zetterberg H, Blennow K, Asthana S, Sager MA, Johnson SC, Alexander AL, Bendlin BB. (2017) Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease. JAMA Neurology, 74(1):41-49. doi: 10.1001/jamaneurol.2016.3232.

Dean DC 3rd, Sojkova J, Hurley S, Kecskemeti S, Okonkwo O, Bendlin BB, Theisen F, Johnson SC, Alexander AL, Gallagher CL. (2016) Alterations of Myelin Content in Parkinson’s Disease: A Cross-Sectional Neuroimaging Study. PLoS One. 5;11(10):e0163774. doi: 10.1371/journal.pone.0163774.

Merluzzi AP, Dean DC 3rd, Adluru N, Suryawanshi GS, Okonkwo OC, Oh JM, Hermann BP, Sager MA, Asthana S, Zhang H, Johnson SC, Alexander AL, Bendlin BB. (2016) Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging. Neurobiology of Aging. 43:79-88. doi: 10.1016/j.neurobiolaging.2016.03.026.

Dean DC 3rd, Travers BG, Adluru N, Tromp do PM, Destiche DJ, Samsin D, Prigge MB, Zielinski BA, Fletcher PT, Anderson JS, Froehlich AL, Bigler ED, Lange N, Lainhart JE, Alexander AL. (2016) Investigating the Microstructural Correlation of White Matter in Autism Spectrum Disorder. Brain Connectivity, 6(5):415-33.

Green RR, Bigler ED, Froehlich A, Prigge MB, Travers BG, Cariello AN, Anderson JS, Zielinski BA, Alexander A, Lange N, Lainhart JE. (2016). Beery VMI performance in autism spectrum disorder. Child Neuropsychology, 22(7):795-817.

Dean DC 3rd, O’Muircheartaigh J, Dirks H, Travers BG, Adluru N, Alexander AL, Deoni SCL. (2016). Mapping an index of the myelin g-ratio in infants using magnetic resonance imaging. Neuroimage, 15;132:225-237.

Jantz PB, Bigler ED, Froehlich AL, Prigge MB, Cariello AN, Travers BG, Anderson J, Zielinski BA, Alexander AL, Lange N, Lainhart JE. (2015) Wide range achievement test in autism spectrum disorder: test-retest stability. Psychological Reports, 116(3):674-84.

Pasha Hosseinbor A, Chung MK, Koay CG, Schaefer SM, van Reekum CM, Schmitz LP, Sutterer M, Alexander AL, Davidson RJ. (2015) 4D hyperspherical harmonic (HyperSPHARM) representation of surface anatomy: A holistic treatment of multiple disconnected anatomical structures. Medical Image Analysis. 22(1):89-101. doi: 10.1016/j.media.2015.02.004.

Fox AS, Oler JA, Shackman AJ, Shelton SE, Raveendran M, McKay DR, Converse AK, Alexander A, Davidson RJ, Blangero J, Rogers J, Kalin NH. (2015) Intergenerational neural mediators of early-life anxious temperament. Proceedings of the National Academy of Sciences USA. 21;112(29):9118-22. doi: 10.1073/pnas.1508593112.

Travers BG, Bigler ED, Tromp do PM, Adluru N, Destiche D, Samsin D, Froehlich A, Prigge MD, Duffield TC, Lange N, Alexander AL, Lainhart JE. (2015). Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism. Journal of Autism and Developmental Disorders, 45(9):3030-40.

Travers BG, Tromp do PM, Adluru N, Lange N, Destiche D, Ennis C, Nielsen JA, Froehlich AL, Prigge MB, Fletcher PT, Anderson JS, Zielinski BA, Bigler ED, Lainhart JE, Alexander AL. (2015). Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation. Molecular Autism, 11;6:15.

Trontel HG, Duffield TC, Bigler ED, Abildskov TJ, Froehlich A, Prigge MB, Travers BG, Anderson JS, Zielinski BA, Alexander AL, Lange N, Lainhart JE. (2015). Mesial temporal lobe and memory function in autism spectrum disorder: an exploration of volumetric findings. Journal of Clinical and Experimental Neuropsychology, 37(2):178-92.

Lange N, Travers BG, Bigler ED, Prigge MB, Froehlich AL, Nielsen JA, Cariello AN, Zielinski BA, Anderson JS, Fletcher PT, Alexander AA, Lainhart JE. (2015). Longitudinal volumetric brain changes in autism spectrum disorder ages 6-35 years. Autism Research, 8(1):82-93

Nielsen JA, Zielinski BA, Fletcher PT, Alexander AL, Lange N, Bigler ED, Lainhart JE, Anderson JS. (2014) Abnormal lateralization of functional connectivity between language and default mode regions in autism. Molecular Autism. 6;5(1):8. doi: 10.1186/2040-2392-5-8.

Travers BG, Bigler ED, Tromp DPM, Adluru N, Froehlich AL, Ennis C, Lange N, Nielsen JA, Prigge MB, Alexander AL, Lainhart JE. (2014) Longitudinal processing speed impairments in males with autism and the effects of white matter microstructureLongitudinal processing speed impairments in males with autism and the effects of white matter microstructure. Neuropsychologia. Neuropsychologia, 53, 137-145.

Birn RM, Shackman AJ, Oler JA, Williams LE, McFarlin DR, Rogers GM, Shelton SE, Alexander AL, Pine DS, Slattery MJ, Davidson RJ, Fox AS, Kalin NH. (2014) Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety. Molecular Psychiatry. 19(8):915-22.

Zielinski BA, Prigge MB, Nielsen JA, Froehlich AL, Abildskov TJ, Anderson JS, Fletcher PT, Zygmunt KM, Travers BG, Lange N, Alexander AL, Bigler ED, Lainhart JE. (2014) Longitudinal changes in cortical thickness in autism and typical development. Brain. 137(Pt 6):1799-812.

Birn RM, Shackman AJ, Oler JA, Williams LE, McFarlin DR, Rogers GM, Shelton SE, Alexander AL, Pine DS, Slattery MJ, Davidson RJ, Fox AS, Kalin NH. (2014) Extreme early-life anxiety is associated with an evolutionarily conserved reduction in the strength of intrinsic functional connectivity between the dorsolateral prefrontal cortex and the central nucleus of the amygdala. Molecular Psychiatry. 19(8):853.

Willette AA, Coe CL, Birdsill AC, Bendlin BB, Colman RJ, Alexander AL, Allison DB, Weindruch RH, Johnson SC. (2013) Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques. Age. Mar 6.

Hanson JL, Adluru N, Chung MK, Alexander AL, Davidson RJ, Pollak SD. (2013) Early Neglect Is Associated With Alterations in White Matter Integrity and Cognitive Functioning. Child Development. 84(5):1566-78.

Trontel HG, Duffield TC, Bigler ED, Froehlich A, Prigge MB, Nielsen JA, Cooperrider JR, Cariello AN, Travers BG, Anderson JS, Zielinski BA, Alexander A, Lange N, Lainhart JE. (2013) Fusiform correlates of facial memory in autism. Behavioral Sciences. 3(3):348-71. doi: 10.3390/bs3030348.

Hosseinbor AP, Chung MK, Wu YC, Alexander AL. (2013) Bessel Fourier Orientation Reconstruction (BFOR): an analytical diffusion propagator reconstruction for hybrid diffusion imaging and computation of q-space indices. NeuroImage. 64:650-70.

Nielsen JA, Zielinski BA, Fletcher PT, Alexander AL, Lange N, Bigler ED, Lainhart JE, Anderson JS. (2013) Multisite functional connectivity MRI classification of autism: ABIDE results. Frontiers in Human Neuroscience. 25;7:599. doi: 10.3389/fnhum.2013.00599.

Adluru N, Hanlon BM, Lutz A, Lainhart JE, Alexander AL, Davidson RJ. (2013) Penalized Likelihood Phenotyping: Unifying Voxelwise Analyses and Multi-Voxel Pattern Analyses in Neuroimaging. Neuroinformatics. 11(2):227-47.

Prigge MB, Lange N, Bigler ED, Merkley TL, Neeley ES, Abildskov TJ, Froehlich AL, Nielsen JA, Cooperrider JR, Cariello AN, Ravichandran C, Alexander AL, Lainhart JE. (2013) Corpus Callosum Area in Children and Adults with Autism. Research in Autism Spectrum Disorders. 7(2):221-234.

Gallagher C, Bell B, Bendlin B, Palotti M, Okonkwo O, Sodhi A, Wong R, Buyan-Dent L, Johnson S, Wilette A, Harding S, Ninman N, Kastman E, Alexander A. (2013) White Matter Microstructural Integrity and Executive Function in Parkinson’s Disease. Journal of the International Neuropsychological Society. 19(3):349-54.

Tromp DP, Grupe DW, Oathes DJ, McFarlin DR, Hernandez PJ, Kral TR, Lee JE, Adams M, Alexander AL, Nitschke JB. (2012) Reduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorder. Archives of General Psychiatry. 69(9):925-34.

Hosseinbor AP, Chung MK, Wu YC, Fleming JO, Field AS, Alexander AL. (2012) Extracting quantitative measures from EAP: a small clinical study using BFOR. Medical Image Computing and Computer-Assisted Intervention. 15(Pt 2):280-7.

Travers BG, Adluru N, Ennis C, Tromp do PM, Destiche D, Doran S, Bigler ED, Lange N, Lainhart JE, Alexander AL. (2012) Diffusion tensor imaging in autism spectrum disorder: a review. Autism Research. 5(5):289-313.

Zielinski BA, Anderson JS, Froehlich AL, Prigge MB, Nielsen JA, Cooperrider JR, Cariello AN, Fletcher PT, Alexander AL, Lange N, Bigler ED, Lainhart JE. (2012) scMRI reveals large-scale brain network abnormalities in autism. PLoS One. 7(11):e49172.

Nacewicz BM, Angelos L, Dalton KM, Fischer R, Anderle MJ, Alexander AL, Davidson RJ. (2012) Reliable non-invasive measurement of human neurochemistry using proton spectroscopy with an anatomically defined amygdala-specific voxel. Neuroimage. 1;59(3):2548-59.

Willette AA, Coe CL, Colman RJ, Bendlin BB, Kastman EK, Field AS, Alexander AL, Allison DB, Weindruch RH, Johnson SC. (2011) Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeys. Psychoneuroendocrinology. 2011 Nov 24. [Epub ahead of print].

Southwick JS, Bigler ED, Froehlich A, Dubray MB, Alexander AL, Lange N, Lainhart JE. (2011) Memory functioning in children and adolescents with autism. Neuropsychology. 25(6):702-10.

Anderson JS, Druzgal TJ, Froehlich A, DuBray MB, Lange N, Alexander AL, Abildskov T, Nielsen JA, Cariello AN, Cooperrider JR, Bigler ED, Lainhart JE. (2011) Decreased interhemispheric functional connectivity in autism. Cerebral Cortex. May;21(5):1134-46.

Anderson JS, Nielsen JA, Froehlich AL, DuBray MB, Druzgal TJ, Cariello AN, Cooperrider JR, Zielinski BA, Ravichandran C, Fletcher PT, Alexander AL, Bigler ED, Lange N, Lainhart JE. (2011) Functional connectivity magnetic resonance imaging classification of autism. Brain. 134(Pt 12):3742-54.

Lange N, Dubray MB, Lee JE, Froimowitz MP, Froehlich A, Adluru N, Wright B, Ravichandran C, Fletcher PT, Bigler ED, Alexander AL, Lainhart JE. (2010) Atypical diffusion tensor hemispheric asymmetry in autism. Autism Research. 3(6):350-8.

Lee JE, Chung MK, Lazar M, DuBray MB, Kim J, Bigler ED, Lainhart JE, Alexander AL. (2009) A study of diffusion tensor imaging by tissue-specific, smoothing-compensated voxel-based analysis. Neuroimage. 1;44(3):870-83.

Jung Y, Samsonov AA, Block WF, Lazar M, Lu A, Liu J, Alexander AL. (2009) 3D diffusion tensor MRI with isotropic resolution using a steady-state radial acquisition. Journal of Magnetic Resonance Imaging. 29(5):1175-84.

Whalen PJ, Johnstone T, Somerville LH, Nitschke JB, Polis S, Alexander AL, Davidson RJ, Kalin NH. (2008) A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder. Biological Psychiatry. May 1;63(9):858-63.

Bendlin BB, Ries ML, Lazar M, Alexander AL, Dempsey RJ, Rowley HA, Sherman JE, Johnson SC. (2008) Longitudinal changes in patients with traumatic brain injury assessed with diffusion-tensor and volumetric imaging. Neuroimage. 15;42(2):503-14.

Ferrarelli F, Massimini M, Peterson MJ, Riedner BA, Lazar M, Murphy MJ, Huber R, Rosanova M, Alexander AL, Kalin N, Tononi G. (2008) Reduced evoked gamma oscillations in the frontal cortex in schizophrenia patients: a TMS/EEG study. American Journal of Psychiatry. 165(8):996-1005.

Wu YC, Field AS, Alexander AL. (2008) Computation of diffusion function measures in q-space using magnetic resonance hybrid diffusion imaging. IEEE Transactions on Medical Imaging. 27(6):858-65.

Andrew Alexander, PhD

Contact Information

Research Statement

Selected Publications