Christian, PhD, Bradley T

Schworer, E. K., Zammit, M. D., Wang, J., Handen, B. L., Betthauser, T., Laymon, C. M., Tudorascu, D. L., Cohen, A. D., Zaman, S. H., Ances, B. M., Mapstone, M., Head, E., Christian, B. T., Hartley, S. L., & Alzheimer’s Biomarker Consortium–Down Syndrome (ABC–DS) (2024). Timeline to symptomatic Alzheimer’s disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study. The Lancet. Neurology, 23(12), 1214–1224. https://doi.org/10.1016/S1474-4422(24)00426-5

Rea Reyes, R. E., Cody, K. A., Wilson, R. E., Zetterberg, H., Chin, N. A., Jonaitis, E. M., Bahr, M., Mandel, O., Wintlend, M., Bendlin, B. B., Okonkwo, O. C., Clark, L. R., Zammit, M., Asthana, S., Christian, B. T., Betthauser, T. J., Eisenmenger, L., Langhough, R. E., & Johnson, S. C. (2024). Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer’s disease. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 10.1002/alz.14406. Advance online publication. https://doi.org/10.1002/alz.14406

Xicota, L., Dang, L. T., Lee, A., Krinsky-McHale, S., Pang, D., Melilli, L., O’Bryant, S., Henson, R. L., Laymon, C., Lai, F., Rosas, H. D., Ances, B., Lott, I., Hom, C., Christian, B., Hartley, S., Zaman, S., Head, E., Mapstone, M., Jin, Z., … Alzheimer’s Biomarker Consortium – Down Syndrome (ABC-DS) (2024). The effects of mosaicism on biological and clinical markers of Alzheimer’s disease in adults with Down syndrome. EBioMedicine, 110, 105433. Advance online publication. https://doi.org/10.1016/j.ebiom.2024.105433

Wisch, J. K., McKay, N. S., Boerwinkle, A. H., Kennedy, J., Flores, S., Handen, B. L., Christian, B. T., Head, E., Mapstone, M., Rafii, M. S., O’Bryant, S. E., Price, J. C., Laymon, C. M., Krinsky-McHale, S. J., Lai, F., Rosas, H. D., Hartley, S. L., Zaman, S., Lott, I. T., Tudorascu, D., … Dominantly Inherited Alzheimer Network (2024). Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer’s disease: a cross-sectional study. The Lancet. Neurology, 23(5), 500–510. https://doi.org/10.1016/S1474-4422(24)00084-X

Cody, K. A., Langhough, R. E., Zammit, M. D., Clark, L., Chin, N., Christian, B. T., Betthauser, T. J., & Johnson, S. C. (2024). Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer’s disease. Brain : a journal of neurology, awae116. Advance online publication. https://doi.org/10.1093/brain/awae116

Schworer, E. K., Handen, B. L., Petersen, M., O’Bryant, S., Peven, J. C., Tudorascu, D. L., Lee, L., Krinsky-McHale, S. J., Hom, C. L., Clare, I. C. H., Christian, B. T., Schupf, N., Lee, J. H., Head, E., Mapstone, M., Lott, I., Ances, B. M., Zaman, S., Brickman, A. M., Lai, F., … Alzheimer Biomarker Consortium‐Down Syndrome (2024). Cognitive and functional performance and plasma biomarkers of early Alzheimer’s disease in Down syndrome. Alzheimer’s & dementia (Amsterdam, Netherlands), 16(2), e12582. https://doi.org/10.1002/dad2.12582

Hillerstrom, H., Fisher, R., Janicki, M. P., Chicoine, B., Christian, B. T., Esbensen, A., Esralew, L., Fortea, J., Hartley, S., Hassenstab, J., Keller, S. M., Krinsky-McHale, S., Lai, F., Levin, J., McCarron, M., McDade, E., Rebillat, A. S., Rosas, H. D., Silverman, W., Strydom, A., … Zetterberg, H. (2024). Adapting prescribing criteria for amyloid-targeted antibodies for adults with Down syndrome. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 10.1002/alz.13778. Advance online publication. https://doi.org/10.1002/alz.13778

Jonaitis, E. M., Hermann, B. P., Mueller, K. D., Clark, L. R., Du, L., Betthauser, T. J., Cody, K., Gleason, C. E., Christian, B. T., Asthana, S., Chappell, R. J., Chin, N. A., Johnson, S. C., & Langhough, R. E. (2024). Longitudinal normative standards for cognitive tests and composites using harmonized data from two Wisconsin AD-risk-enriched cohorts. Alzheimer’s & dementia: the journal of the Alzheimer’s Association, 10.1002/alz.13774. Advance online publication. https://doi.org/10.1002/alz.13774

DiFilippo, A., Jonaitis, E., Makuch, R., Gambetti, B., Fleming, V., Ennis, G., Barnhart, T., Engle, J., Bendlin, B., Johnson, S., Handen, B., Krinsky-McHale, S., Hartley, S., & Christian, B. (2024). Measurement of synaptic density in Down syndrome using PET imaging: a pilot study. Scientific reports, 14(1), 4676. https://doi.org/10.1038/s41598-024-54669-7

Zammit, M. D., Betthauser, T. J., McVea, A. K., Laymon, C. M., Tudorascu, D. L., Johnson, S. C., Hartley, S. L., Converse, A. K., Minhas, D. S., Zaman, S. H., Ances, B. M., Stone, C. K., Mathis, C. A., Cohen, A. D., Klunk, W. E., Handen, B. L., Christian, B. T., & Alzheimer’s Biomarker Consortium – Down Syndrome (2024). Characterizing the emergence of amyloid and tau burden in Down syndrome. Alzheimer’s & dementia, 20(1), 388–398. https://doi.org/10.1002/alz.13444

Hartley, S. L., Handen, B., Tudorascu, D., Lee, L., Cohen, A., Schworer, E. K., Peven, J. C., Zammit, M., Klunk, W., Laymon, C., Minhas, D., Luo, W., Zaman, S., Ances, B., Preboske, G., Christian, B. T., & Alzheimer Biomarker Consortium – Down Syndrome (2024). AT(N) biomarker profiles and Alzheimer’s disease symptomology in Down syndrome. Alzheimer’s & dementia, 20(1), 366–375. https://doi.org/10.1002/alz.13446.

Fleming, V., Helsel, B. C., Ptomey, L. T., Rosas, H. D., Handen, B., Laymon, C., Christian, B. T., Head, E., Mapstone, M., Lai, F., Krinsky-McHale, S., Zaman, S., Ances, B. M., Lee, J. H., Hartley, S. L., & Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS) Consortium (2023). Weight Loss and Alzheimer’s Disease in Down Syndrome. Journal of Alzheimer’s disease : JAD, 91(3), 1215–1227. https://doi.org/10.3233/JAD-220865

Stern, A. M., Van Pelt, K. L., Liu, L., Anderson, A. K., Ostaszewski, B., Mapstone, M., O’Bryant, S., Petersen, M. E., Christian, B. T., Handen, B. L., Selkoe, D. J., Schmitt, F., Head, E., & Alzheimer’s Biomarker Consortium-Down Syndrome (ABC-DS) investigators (2023). Plasma NT1-tau and Aβ₄₂ correlate with age and cognitive function in two large Down syndrome cohorts. Alzheimer’s & dementia, 10.1002/alz.13382. Advance online publication. https://doi.org/10.1002/alz.13382

Hartley, S. L., Fleming, V., Schworer, E. K., Peven, J., Handen, B. L., Krinsky-McHale, S., Hom, C., Lee, L., Tudorascu, D. L., Laymon, C., Minhas, D., Luo, W., Cohen, A., Zaman, S., Ances, B. M., Mapstone, M., Head, E., Lai, F., Rosas, H. D., Klunk, W., … Alzheimer Biomarker Consortium-Down Syndrome (2023). Timing of Alzheimer’s Disease by Intellectual Disability Level in Down Syndrome. Journal of Alzheimer’s Disease, 95(1), 213–225. https://doi.org/10.3233/JAD-230200

Boerwinkle, A. H., Gordon, B. A., Wisch, J., Flores, S., Henson, R. L., Butt, O. H., McKay, N., Chen, C. D., Benzinger, T. L. S., Fagan, A. M., Handen, B. L., Christian, B. T., Head, E., Mapstone, M., Rafii, M. S., O’Bryant, S., Lai, F., Rosas, H. D., Lee, J. H., Silverman, W., … Dominantly Inherited Alzheimer Network (2023). Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer’s disease: a cross-sectional study. The Lancet. Neurology, 22(1), 55–65. https://doi.org/10.1016/S1474-4422(22)00408-2

Fleming, V., Piro-Gambetti, B., Handen, B., Christian, B. T., Cohen, A., Tudorascu, D., Plante, D. T., Okonkwo, O., & Hartley, S. L. (2022). Physical activity and physical and mental health in middle-aged adults with Down syndrome. Journal of policy and practice in intellectual disabilities, 19(4), 408–418. https://doi.org/10.1111/jppi.12434.

Betthauser, T. J., Bilgel, M., Koscik, R. L., Jedynak, B. M., An, Y., Kellett, K. A., Moghekar, A., Jonaitis, E. M., Stone, C. K., Engelman, C. D., Asthana, S., Christian, B. T., Wong, D. F., Albert, M., Resnick, S. M., Johnson, S. C., & Alzheimer’s Disease Neuroimaging Initiative (2022). Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts. Brain : a journal of neurology, 145(11), 4065–4079. https://doi.org/10.1093/brain/awac213

Hartley, S. L., Handen, B. L., Tudorascu, D., Lee, L., Cohen, A., Piro-Gambetti, B., Zammit, M., Klunk, W., Laymon, C., Zaman, S., Ances, B. M., Sabbagh, M., & Christian, B. T. (2022). Role of tau deposition in early cognitive decline in Down syndrome. Alzheimer’s & dementia (Amsterdam, Netherlands), 14(1), e12256. https://doi.org/10.1002/dad2.12256

Padilla, C., Montal, V., Walpert, M. J., Hong, Y. T., Fryer, T. D., Coles, J. P., Aigbirhio, F. I., Hartley, S. L., Cohen, A. D., Tudorascu, D. L., Christian, B. T., Handen, B. L., Klunk, W. E., Holland, A. J., & Zaman, S. H. (2022). Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study. Alzheimer’s & dementia (Amsterdam, Netherlands), 14(1), e12288. https://doi.org/10.1002/dad2.12288

Buchsbaum, M. S., Mitelman, S. A., Christian, B. T., Merrill, B. M., Buchsbaum, B. R., Mitelman, D., Mukherjee, J., & Lehrer, D. S. (2022). Four-modality imaging of unmedicated subjects with schizophrenia: ¹⁸F-fluorodeoxyglucose and ¹⁸F-fallypride PET, diffusion tensor imaging, and MRI. Psychiatry research. Neuroimaging, 320, 111428. https://doi.org/10.1016/j.pscychresns.2021.111428

Bazydlo, A. M., Zammit, M. D., Wu, M., Lao, P. J., Dean, D. C., 3rd, Johnson, S. C., Tudorascu, D. L., Cohen, A., Cody, K. A., Ances, B., Laymon, C. M., Klunk, W. E., Zaman, S., Handen, B. L., Hartley, S. L., Alexander, A. L., & Christian, B. T. (2022). White matter microstructure associations to amyloid burden in adults with Down syndrome. NeuroImage. Clinical, 33, 102908. https://doi.org/10.1016/j.nicl.2021.102908

Rosenkranz, M. A., Esnault, S., Gresham, L., Davidson, R. J., Christian, B. T., Jarjour, N. N., & Busse, W. W. (2022). Role of amygdala in stress-induced upregulation of airway IL-1 signaling in asthma. Biological psychology, 167, 108226. https://doi.org/10.1016/j.biopsycho.2021.108226

Mitelman, S. A., Buchsbaum, M. S., Vyas, N. S., Christian, B. T., Merrill, B. M., Buchsbaum, B. R., Mitelman, A. M., Mukherjee, J., & Lehrer, D. S. (2021). Reading abilities and dopamine D₂/D₃ receptor availability: An inverted U-shaped association in subjects with schizophrenia. Brain and language, 223, 105046. https://doi.org/10.1016/j.bandl.2021.105046

Fleming, V., Piro-Gambetti, B., Patrick, A., Zammit, M., Alexander, A., Christian, B. T., Handen, B., Cohen, A., Klunk, W., Laymon, C., Ances, B. M., Plante, D. T., Okonkwo, O., & Hartley, S. L. (2021). Physical activity and cognitive and imaging biomarkers of Alzheimer’s disease in down syndrome. Neurobiology of aging, 107, 118–127. https://doi.org/10.1016/j.neurobiolaging.2021.07.016

Fleming, V., Piro-Gambetti, B., Bazydlo, A., Zammit, M., Alexander, A. L., Christian, B. T., Handen, B., Plante, D. T., & Hartley, S. L. (2021). Sleep and White Matter in Adults with Down Syndrome. Brain sciences, 11(10), 1322. https://doi.org/10.3390/brainsci11101322

Ennis, G. E., Kohli, A., Jonaitis, E. M., Betthauser, T. J., Oh, J. M., Taylor, C. E., Chin, N., Koscik, R. L., Christian, B. T., Asthana, S., Johnson, S. C., & Bendlin, B. B. (2021). The relationship of glucose-stimulated insulin secretion to cerebral glucose metabolism and cognition in healthy middle-aged and older adults. Neurobiology of aging, 105, 174–185. https://doi.org/10.1016/j.neurobiolaging.2021.04.028

Bruno, D., Mueller, K. D., Betthauser, T., Chin, N., Engelman, C. D., Christian, B., Koscik, R. L., & Johnson, S. C. (2021). Serial position effects in the Logical Memory Test: Loss of primacy predicts amyloid positivity. Journal of neuropsychology, 15(3), 448–461. https://doi.org/10.1111/jnp.12235

Vogt, N. M., Hunt, J., Ma, Y., Van Hulle, C. A., Adluru, N., Chappell, R. J., Lazar, K. K., Jacobson, L. E., Austin, B. P., Asthana, S., Johnson, S. C., Bendlin, B. B., & Carlsson, C. M. (2021). Effects of simvastatin on white matter integrity in healthy middle-aged adults. Annals of clinical and translational neurology, 8(8), 1656–1667. https://doi.org/10.1002/acn3.51421

Martinez, J. L., Zammit, M. D., West, N. R., Christian, B. T., & Bhattacharyya, A. (2021). Corrigendum: Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimer’s Disease. Frontiers in aging neuroscience, 13, 742233. https://doi.org/10.3389/fnagi.2021.742233

Fagan, A. M., Henson, R. L., Li, Y., Boerwinkle, A. H., Xiong, C., Bateman, R. J., Goate, A., Ances, B. M., Doran, E., Christian, B. T., Lai, F., Rosas, H. D., Schupf, N., Krinsky-McHale, S., Silverman, W., Lee, J. H., Klunk, W. E., Handen, B. L., Allegri, R. F., Chhatwal, J. P., … Dominantly Inherited Alzheimer Network (2021). Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer’s disease: a cross-sectional study. The Lancet. Neurology, 20(8), 615–626. https://doi.org/10.1016/S1474-4422(21)00139-3

Ennis, G. E., Koscik, R. L., Ma, Y., Jonaitis, E. M., Van Hulle, C. A., Betthauser, T. J., Randall, A. M., Chin, N., Engelman, C. D., Anderson, R., Suridjan, I., Kollmorgen, G., Christian, B. T., Carlsson, C. M., Asthana, S., Johnson, S. C., Zetterberg, H., Blennow, K., & Bendlin, B. B. (2021). Insulin resistance is related to cognitive decline but not change in CSF biomarkers of Alzheimer’s disease in non-demented adults. Alzheimer’s & dementia (Amsterdam, Netherlands), 13(1), e12220. https://doi.org/10.1002/dad2.12220

Martinez, J. L., Zammit, M. D., West, N. R., Christian, B. T., & Bhattacharyya, A. (2021). Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimer’s Disease. Frontiers in aging neuroscience, 13, 703876. https://doi.org/10.3389/fnagi.2021.703876

Zammit, M. D., Tudorascu, D. L., Laymon, C. M., Hartley, S. L., Ellison, P. A., Zaman, S. H., Ances, B. M., Johnson, S. C., Stone, C. K., Sabbagh, M. N., Mathis, C. A., Klunk, W. E., Cohen, A. D., Handen, B. L., & Christian, B. T. (2021). Neurofibrillary tau depositions emerge with subthreshold cerebral beta-amyloidosis in down syndrome. NeuroImage. Clinical, 31, 102740. https://doi.org/10.1016/j.nicl.2021.102740

O’Bryant, S. E., Johnson, L. A., Barber, R. C., Braskie, M. N., Christian, B., Hall, J. R., Hazra, N., King, K., Kothapalli, D., Large, S., Mason, D., Matsiyevskiy, E., McColl, R., Nandy, R., Palmer, R., Petersen, M., Philips, N., Rissman, R. A., Shi, Y., Toga, A. W., … HABLE Study Team (2021). The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics. Alzheimer’s & dementia (Amsterdam, Netherlands), 13(1), e12202. https://doi.org/10.1002/dad2.12202

Mueller, K. D., Van Hulle, C. A., Koscik, R. L., Jonaitis, E., Peters, C. C., Betthauser, T. J., Christian, B., Chin, N., Hermann, B. P., & Johnson, S. (2021). Amyloid beta associations with connected speech in cognitively unimpaired adults. Alzheimer’s & dementia (Amsterdam, Netherlands), 13(1), e12203. https://doi.org/10.1002/dad2.12203

Bazydlo, A., Zammit, M., Wu, M., Dean, D., Johnson, S., Tudorascu, D., Cohen, A., Cody, K., Ances, B., Laymon, C., Klunk, W., Zaman, S., Handen, B., Alexander, A., Christian, B., & Hartley, S. (2021). White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study. Journal of neurodevelopmental disorders, 13(1), 17. https://doi.org/10.1186/s11689-021-09366-1

Tao, Y., Vermilyea, S. C., Zammit, M., Lu, J., Olsen, M., Metzger, J. M., Yao, L., Chen, Y., Phillips, S., Holden, J. E., Bondarenko, V., Block, W. F., Barnhart, T. E., Schultz-Darken, N., Brunner, K., Simmons, H., Christian, B. T., Emborg, M. E., & Zhang, S. C. (2021). Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys. Nature medicine, 27(4), 632–639. https://doi.org/10.1038/s41591-021-01257-1

Zammit, M. D., Tudorascu, D. L., Laymon, C. M., Hartley, S. L., Zaman, S. H., Ances, B. M., Johnson, S. C., Stone, C. K., Mathis, C. A., Klunk, W. E., Cohen, A. D., Handen, B. L., & Christian, B. T. (2021). PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer’s disease progression in Down syndrome. NeuroImage, 228, 117728. https://doi.org/10.1016/j.neuroimage.2021.117728

Petersen, M. E., Rafii, M. S., Zhang, F., Hall, J., Julovich, D., Ances, B. M., Schupf, N., Krinsky-McHale, S. J., Mapstone, M., Silverman, W., Lott, I., Klunk, W., Head, E., Christian, B., Foroud, T., Lai, F., Diana Rosas, H., Zaman, S., Wang, M. C., Tycko, B., … Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS) (2021). Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer’s Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome. Journal of Alzheimer’s disease : JAD, 79(2), 671–681. https://doi.org/10.3233/JAD-201167

Zammit, M. D., Laymon, C. M., Tudorascu, D. L., Hartley, S. L., Piro-Gambetti, B., Johnson, S. C., Stone, C. K., Mathis, C. A., Zaman, S. H., Klunk, W. E., Handen, B. L., Cohen, A. D., & Christian, B. T. (2021). Patterns of glucose hypometabolism in Down syndrome resemble sporadic Alzheimer’s disease except for the putamen. Alzheimer’s & dementia (Amsterdam, Netherlands), 12(1), e12138. https://doi.org/10.1002/dad2.12138

Mueller, K. D., Koscik, R. L., Du, L., Bruno, D., Jonaitis, E. M., Koscik, A. Z., Christian, B. T., Betthauser, T. J., Chin, N. A., Hermann, B. P., & Johnson, S. C. (2020). Proper names from story recall are associated with beta-amyloid in cognitively unimpaired adults at risk for Alzheimer’s disease. Cortex; a journal devoted to the study of the nervous system and behavior, 131, 137–150. https://doi.org/10.1016/j.cortex.2020.07.008

Hartley, S. L., Handen, B. L., Devenny, D., Tudorascu, D., Piro-Gambetti, B., Zammit, M. D., Laymon, C. M., Klunk, W. E., Zaman, S., Cohen, A., & Christian, B. T. (2020). Cognitive indicators of transition to preclinical and prodromal stages of Alzheimer’s disease in Down syndrome. Alzheimer’s & dementia (Amsterdam, Netherlands), 12(1), e12096. https://doi.org/10.1002/dad2.12096

Cody, K. A., Piro-Gambetti, B., Zammit, M. D., Christian, B. T., Handen, B. L., Klunk, W. E., Zaman, S., Johnson, S. C., Plante, D. T., & Hartley, S. L. (2020). Association of sleep with cognition and beta amyloid accumulation in adults with Down syndrome. Neurobiology of aging, 93, 44–51. https://doi.org/10.1016/j.neurobiolaging.2020.04.018

Mihaila, I., Handen, B. L., Christian, B. T., & Hartley, S. L. (2020). Leisure activity in middle-aged adults with Down syndrome: Initiators, social partners, settings and barriers. Journal of applied research in intellectual disabilities : JARID, 33(5), 865–875. https://doi.org/10.1111/jar.12706

Handen, B. L., Lott, I. T., Christian, B. T., Schupf, N., OBryant, S., Mapstone, M., Fagan, A. M., Lee, J. H., Tudorascu, D., Wang, M. C., Head, E., Klunk, W., Ances, B., Lai, F., Zaman, S., Krinsky-McHale, S., Brickman, A. M., Rosas, H. D., Cohen, A., Andrews, H., … Alzheimer’s Biomarker Consortium‐Down Syndrome (ABC‐DS) (2020). The Alzheimer’s Biomarker Consortium-Down Syndrome: Rationale and methodology. Alzheimer’s & dementia (Amsterdam, Netherlands), 12(1), e12065. https://doi.org/10.1002/dad2.12065

Henson, R. L., Doran, E., Christian, B. T., Handen, B. L., Klunk, W. E., Lai, F., Lee, J. H., Rosas, H. D., Schupf, N., Zaman, S. H., Lott, I. T., & Fagan, A. M. (2020). Cerebrospinal fluid biomarkers of Alzheimer’s disease in a cohort of adults with Down syndrome. Alzheimer’s & dementia (Amsterdam, Netherlands), 12(1), e12057. https://doi.org/10.1002/dad2.12057

Zammit MD, Laymon CM, Betthauser TJ, Cody KA, Tudorascu DL, Minhas DS, Sabbagh MN, Johnson SC, Zaman SH, Mathis CA, Klunk WE, Handen BL, Cohen AD, Christian BT. (2020). Amyloid accumulation in Down syndrome measured with amyloid load. Alzheimer’s & Dementia, 12(1):e12020. doi: 10.1002/dad2.12020. PMID: 32435686; PMCID: PMC7233422.

Mapstone M, Gross TJ, Macciardi F, Cheema AK, Petersen M, Head E, Handen BL, Klunk WE, Christian BT, Silverman W, Lott IT, Schupf N; Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators. (2020). Metabolic correlates of prevalent mild cognitive impairment and Alzheimer’s disease in adults with Down syndrome. Alzheimer’s & Dementia (Amst), 12(1):e12028. doi: 10.1002/dad2.12028. PMID: 32258359; PMCID: PMC7131985.

Betthauser TJ, Koscik RL, Jonaitis EM, Allison SL, Cody KA, Erickson CM, Rowley HA, Stone CK, Mueller KD, Clark LR, Carlsson CM, Chin NA, Asthana S, Christian BT, Johnson SC. (2020). Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age. Brain, 143(1):320-335. doi: 10.1093/brain/awz378.

Mak E, Bickerton A, Padilla C, Walpert MJ, Annus T, Wilson LR, Hong YT, Fryer TD, Coles JP, Aigbirhio FI, Christian BT, Handen BL, Klunk WE, Menon DK, Nestor PJ, Zaman SH, Holland AJ. (2019). Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report. Alzheimers Dementia, 25;11:654-658. doi: 10.1016/j.dadm.2019.04.006.

Mitelman SA, Buchsbaum MS, Christian BT, Merrill BM, Buchsbaum BR, Mukherjee J, Lehrer DS. (2019). Positive association between cerebral grey matter metabolism and dopamine D₂/D₃ receptor availability in healthy and schizophrenia subjects: An ¹⁸F-fluorodeoxyglucose and ¹⁸F-fallypride positron emission tomography study. World Journal of Biological Psychiatry, 7:1-15. doi: 10.1080/15622975.2019.1671609.

Mihaila I, Handen BL, Christian BT, Lao PJ, Cody KA, Klunk WE, Tudorascu DL, Cohen AD, Okonkwo OC, Hartley SL. (2019). Leisure Activity, Brain β-amyloid, and Episodic Memory in Adults with Down Syndrome. Developmental Neurobiology, 79(7):738-749. doi: 10.1002/dneu.22677.

Abrahamson EE, Head E, Lott IT, Handen BL, Mufson EJ, Christian BT, Klunk WE, Ikonomovic MD. (2019). Neuropathological correlates of amyloid PET imaging in Down syndrome. Developmental Neurobiology, 79(7):750-766. doi: 10.1002/dneu.22713.

Clark LR, Koscik RL, Allison SL, Berman SE, Norton D, Carlsson CM, Betthauser TJ, Bendlin BB, Christian BT, Chin NA, Asthana S, Johnson SC. (2019). Hypertension and obesity moderate the relationship between β-amyloid and cognitive decline in midlife. Alzheimers & Dementia, 15(3):418-428. doi: 10.1016/j.jalz.2018.09.008.

Birn RM, Converse AK, Rajala AZ, Alexander AL, Block WF, McMillan AB, Christian BT, Filla CN, Murali D, Hurley SA, Jenison RL, Populin LC. (2019). Changes in endogenous dopamine induced by methylphenidate predict functional connectivity in non-human primates. Journal of Neuroscience, 39(8):1436-1444. doi: 10.1523/JNEUROSCI.2513-18.2018.

Tudorascu DL, Anderson SJ, Minhas DS, Yu Z, Comer D, Lao P, Hartley S, Laymon CM, Snitz BE, Lopresti BJ, Johnson S, Price JC, Mathis CA, Aizenstein HJ, Klunk WE, Handen BL, Christian BT, Cohen AD. (2019). Comparison of longitudinal Aβ in nondemented elderly and Down syndrome. Neurobiology of Aging, 73:171-176. doi: 10.1016/j.neurobiolaging.2018.09.030.

Betthauser TJ, Cody KA, Zammit MD, Murali D, Converse AK, Barnhart TE, Stone CK, Rowley HA, Johnson SC, Christian BT. (2019). In vivo characterization and quantification of neurofibrillary tau PET radioligand [¹⁸F]MK-6240 in humans from Alzheimer’s disease dementia to young controls. Journal of Nuclear Medicine, 60(1):93-99. doi: 10.2967/jnumed.118.209650.

Mitelman SA, Buchsbaum MS, Christian BT, Merrill BM, Buchsbaum BR, Mukherjee J, Lehrer DS. (2018). Dopamine receptor density and white mater integrity: ¹⁸F-fallypride positron emission tomography and diffusion tensor imaging study in healthy and schizophrenia subjects. Brain Imaging & Behavior. In Press. doi: 10.1007/s11682-018-0012-0.

Metzger JM, Moore CF, Boettcher CA, Brunner KG, Fleddermann RA, Matsoff HN, Resnikoff HA, Bondarenko V, Kamp TJ, Hacker TA, Barnhart TE, Lao PJ, Christian BT, Nickles RJ, Gallagher CL, Holden JE, Emborg ME. (2018). In vivo imaging of inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration. NPJ Parkinson’s Disease, 13;4:22. doi: 10.1038/s41531-018-0057-1.

Lao PJ, Handen BL, Betthauser TJ, Cody KA, Cohen AD, Tudorascu DL, Stone CK, Price JC, Johnson SC, Klunk WE, Christian BT. (2018). Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation. Brain Imaging and Behavior, 13(2):345-353. doi: 10.1007/s11682-018-9888-y.

Tudorascu DL, Minhas DS, Lao PJ, Betthauser TJ, Yu Z, Laymon CM, Lopresti BJ, Mathis CA, Klunk WE, Handen BL, Christian BT, Cohen AD. (2018). The use of Centiloids for applying [¹¹C]PiB classification cutoffs across region-of-interest delineation methods. Alzheimer’s and Dementia (Amst), 21;10:332-339. doi: 10.1016/j.dadm.2018.03.006.

Vyas NS, Buchsbaum MS, Lehrer DS, Merrill BM, DeCastro A, Doninger NA, Christian BT, Mukherjee J. (2018). D2/D3 dopamine receptor binding with [F-18]fallypride correlates of executive function in medication-naïve patients with schizophrenia. Schizophrenia Research, 192:442-456. doi: 10.1016/j.schres.2017.05.017.

Lao PJ, Handen BL, Betthauser TJ, Mihaila I, Hartley SL, Cohen AD, Tudorascu DL, Bulova PD, Lopresti BJ, Tumuluru RV, Murali D, Mathis CA, Barnhart TE, Stone CK, Price JC, Devenny DA, Johnson SC, Klunk WE, Christian BT. (2018). Alzheimer-Like Pattern of Hypometabolism Emerges with Elevated Amyloid-β Burden in Down Syndrome. Journal of Alzheimers Disease, 61(2):631-644. doi: 10.3233/JAD-170720.

Mukherjee J, Lao PJ, Betthauser TJ, Samra GK, Pan ML, Patel IH, Liang C, Metherate R, Christian BT. (2018) Human brain imaging of nicotinic acetylcholine α4β2* receptors using [18 F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways. Comparative Neurology. 526(1): 80-95.

Betthauser TJ, Hillmer AT, Lao PJ, Ehlerding E, Mukherjee J, Stone CK, Christian BT. (2017) Human biodistribution and dosimetry of [18F]nifene, an α4β2* nicotinic acetylcholine receptor PET tracer. Nuclear Medicine and Biology. 55:7-11.

Betthauser TJ, Ellison PA, Murali D, Lao PJ, Barnhart TE, Furumoto S, Okamura N, Johnson SC, Engle JW, Nickles RJ, Christian BT. (2017) Characterization of the radiosynthesis and purification of [18F]THK-5351, a PET ligand for neurofibrillary tau. Applied Radiation and Isotopes. 130:230-237.

Darst BF, Koscik RL, Racine AM, Oh JM, Krause RA, Carlsson CM, Zetterberg H, Blennow K, Christian BT, Bendlin BB, Okonkwo OC, Hogan KJ, Hermann BP, Sager MA, Asthana S, Johnson SC, Engelman CD. (2017) Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer’s Disease. Journal of Alzheimer’s Disease, 55(2):473-484.

Dougherty RJ, Schultz SA, Kirby TK, Boots EA, Oh JM, Edwards D, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Johnson SC, Cook DB, Okonkwo OC. (2017) Moderate Physical Activity is Associated with Cerebral Glucose Metabolism in Adults at Risk for Alzheimer’s Disease. Journal of Alzheimer’s Disease. 58(4):1089-1097.

Hartley SL, Handen BL, Devenny D, Mihaila I, Hardison R, Lao PJ, Klunk WE, Bulova P, Johnson SC, Christian BT. (2017) Cognitive decline and brain amyloid-β accumulation across 3 years in adults with Down syndrome. Neurobiology of Aging. 58:68-76.

Mihaila I, Hartley SL, Handen BL, Bulova PD, Tumuluru RV, Devenny DA, Johnson SC, Lao PJ, Christian BT. (2017) Leisure Activity and Caregiver Involvement in Middle-Aged and Older Adults With Down Syndrome. Intellectual and Developmental Disabilities. 55(2):97-109.

Nicholas CR, Hoscheidt SM, Clark LR, Racine AM, Berman SE, Koscik RL, Maritza Dowling N, Asthana S, Christian BT, Sager MA, Johnson SC. (2017) Positive affect predicts cerebral glucose metabolism in late middle-aged adults. Social Cognitive and Affective Neuroscience. 12(6):993-100. 12(6):993-100.

Betthauser TJ, Lao PJ, Murali D, Barnhart TE, Furumoto S, Okamura N, Stone CK, Johnson SC, Christian BT. (2017) In vivo comparison of tau radioligands [18F]THK-5351 and [18F]THK-5117. Journal of Nuclear Medicine. 58(6):996-1002.

Boots EA, Schultz SA, Clark LR, Racine AM, Darst BF, Koscik RL, Carlsson CM, Gallagher CL, Hogan KJ, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Dubal DB, Engelman CD, Johnson SC, Okonkwo OC. (2017) BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer’s Prevention. Neurology. 88(22):2098-2106.

Lao PJ, Handen BL, Betthauser TJ, Mihaila I, Harley SL, Cohen AD, Tudorascu DL, Bulova PD, Lopresti BJ, Tumuluru RV, Murali D, Mathis CA, Barnhart TE, Stone CK, Price JC, Devenny DA, Mailick MR, Klunk WE, Johnson SC, Christian BT. (2017) Longitudinal changes in amyloid positron emission tomography and volumetric magnetic resonance imaging in the nondemented Down syndrome population. Alzheimer’s & Dementia. 23(9):1-9.

Lao PJ, Betthauser TJ, Tudorascu DL, Barnhart TE, Hillmer AT, Stone CK, Mukherjee J, Christian BT. (2017) [18 F]Nifene test-retest reproducibility in first-in-human imaging of α4β2* nicotinic acetylcholine receptors. Synapse. 71(8).

Racine AM, Koscik RL, Nicholas CR, Clark LR, Okonkwo OC, Oh JM, Hillmer AT, Murali D, Barnhart TE, Betthauser TJ, Gallagher CL, Rowley HA, Dowling NM, Asthana S, Bendlin BB, Blennow K, Zetterberg H, Carlsson CM, Christian BT, Johnson SC. (2016) Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation. Alzheimer’s & Dementia. 2:27-38.

Rosenkranz MA, Esnault S, Christian BT, Crisafi G, Gresham LK, Higgins AT, Moore MN, Moore SM, Weng HY, Salk RH, Busse WW, Davidson RJ. (2016) Mind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress. Brain, Behavior, and Immunity. 58:18-30.

Clark LR, Racine AM, Koscik RL, Okonkwo OC, Engelman CD, Carlsson CM, Asthana S, Bendlin BB, Chappell R, Nicholas CR, Rowley HA, Oh JM, Hermann BP, Sager MA, Christian BT, Johnson SC. (2016) Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer’s Prevention study. Alzheimers & Dementia. 12(7):805-14. doi: 10.1016/j.jalz.2015.12.009.

Racine AM, Clark LR, Berman SE, Koscik RL, Mueller KD, Norton D, Nicholas CR, Blennow K, Zetterberg H, Jedynak B, Bilgel M, Carlsson CM, Christian BT, Asthana S, Johnson SC. (2016) Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer’s Disease. Journal of Alzheimer’s Disease. 18;54(4):1395-1408.

Albrecht DS, MacKie PJ, Kareken DA, Hutchins GD, Chumin EJ, Christian BT, Yoder KK. (2016) Differential dopamine function in fibromyalgia. Brain Imaging and Behavior. 10(3):829-839, 2016.

Mukherjee J, Bajwa AK, Wooten DW, Hillmer AT, Pan ML, Pandey SK, Saigal N, Christian BT. (2016) Comparative assessment of 18F-Mefway as a serotonin 5-HT1A receptor PET imaging agent across species-rodents, nonhuman primates, and humans. The Journal of Comparative Neurology. 524(7):1457-1471.

Lao PJ, Betthauser TJ, Hillmer AT, Price JC, Klunk WE, Mihaila I, Higgins AT, Bulova PD, Hartley SL, Hardison R, Tumuluru RV, Murali D, Mathis CA, Cohen AD, Barnhart TE, Devenny DA, Mailick MR, Johnson SC, Handen BL, Christian BT. (2016) The effects of normal aging on amyloid-β deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B. Alzheimer’s & Dementia. 12(4):380-390.

Gallagher CL, Bell B, Palotti M, Oh J, Christian BT, Okonkwo O, Sojkova J, Buyan-Dent L, Nickles RJ, Harding SJ, Stone CK, Johnson SC, Holden JE. (2015) Anterior cingulate dopamine turnover and behavior change in Parkinson’s disease. Brain Imagining and Behavior. 9(4):821-827.

Schultz SA, Boots EA, Almeida RP, Oh JM, Einerson J, Korcarz CE, Edwards DF, Koscik RL, Dowling MN, Gallagher CL, Bendlin BB, Christian BT, Zetterberg H, Blennow K, Carlsson CM, Asthana S, Hermann BP, Sager MA, Johnson SC, Stein JH, Okonkwo OC. (2015) Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition. Journal of the International Neuropsychological Society: JINS, 21(10), 841–850. https://doi.org/10.1017/S1355617715000843

Willette AA, Johnson SC, Birdsill AC, Sager MA, Christian B, Baker LD, Craft S, Oh J, Statz E, Hermann BP, Jonaitis EM, Koscik RL, La Rue A, Asthana S, Bendlin BB. (2015) Insulin resistance predicts brain amyloid deposition in late middle-aged adults. Alzheimer’s & Dementia. 11(5):504-510.e1. doi: 10.1016/j.jalz.2014.03.011.

Sprecher KE, Bendlin BB, Racine AM, Okonkwo OC, Christian BT, Koscik RL, Sager MA, Asthana S, Johnson SC, Benca RM. (2015) Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults. Neurobiol Aging. 36(9):2568-76. doi: 10.1016/j.neurobiolaging.2015.05.004.

Willette AA, Bendlin BB, Starks EJ, Birdsill AC, Johnson SC, Christian BT, Okonkwo OC, La Rue A, Hermann BP, Koscik RL, Jonaitis EM, Sager MA, Asthana S. (2015) Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease.. JAMA Neurology. 72(9):1013-20. doi: 10.1001/jamaneurol.2015.0613.

Thio JP, Liang C, Bajwa AK, Wooten DW, Christian BT, Mukherjee J. (2015) Synthesis and evaluation of mefway analogs as ligands for serotonin 5HT1A receptors. Medical Chemistry Research. 24(4):1480-1486.

Converse AK, Moore CF, Holden JE, Ahlers EO, Moirano JM, Larson JA, Resch LM, DeJesus OT, Barnhart TE, Nickles RJ, Murali D, Christian BT, Schneider ML. (2014) Moderate-level prenatal alcohol exposure induces sex differences in dopamine d1 receptor binding in adult rhesus monkeys. Alcoholism: Clinical and Experimental Research. 38(12):2934-43. doi: 10.1111/acer.12575.

Peng Y, Li M, Clarkson BD, Pehar M, Lao PJ, Hillmer AT, Barnhart TE, Christian BT, Mitchell HA, Bendlin BB, Sandor M, Puglielli L. (2014) Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer. Journal of Neuroscience. 14;34(20):6772-89. doi: 10.1523/JNEUROSCI.0077-14.2014.

Hartley SL, Handen BL, Devenny DA, Hardison R, Mihaila I, Price JC, Cohen AD, Klunk WE, Mailick MR, Johnson SC, Christian BT. (2014) Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome. Brain. 137(Pt 9):2556-63.

Johnson SC, Christian BT, Okonkwo OC, Oh JM, Harding S, Xu G, Hillmer AT, Wooten DW, Murali D, Barnhart TE, Hall LT, Racine AM, Klunk WE, Mathis CA, Bendlin BB, Gallagher CL, Carlsson CM, Rowley HA, Hermann BP, Dowling NM, Asthana S, Sager MA. (2014) Amyloid burden and neural function in people at risk for Alzheimer’s Disease. Neurobiology of Aging. 35(3):576-84.

Okonkwo OC, Oh JM, Koscik R, Jonaitis E, Cleary CA, Dowling NM, Bendlin BB, Larue A, Hermann BP, Barnhart TE, Murali D, Rowley HA, Carlsson CM, Gallagher CL, Asthana S, Sager MA, Christian BT, Johnson SC. (2014) Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer’s disease. Journal of the International Neuropsychological Society. 20(4):422-33.

Okonkwo OC, Schultz SA, Oh JM, Larson J, Edwards D, Cook D, Koscik R, Gallagher CL, Dowling NM, Carlsson CM, Bendlin BB, LaRue A, Rowley HA, Christian BT, Asthana S, Hermann BP, Johnson SC, Sager MA. (2014) Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology. 4;83(19):1753-60. doi: 10.1212/WNL.0000000000000964.

Hillmer AT, Wooten DW, Tudorascu DL, Barnhart TE, Ahlers EO, Resch LM, Larson JA, Converse AK, Moore CF, Schneider ML, Christian BT. (2014) The effects of chronic alcohol self-administration on serotonin-1A receptor binding in nonhuman primates. Drug and Alcohol Dependence. 144:119-26.

Wooten DW, Hillmer AT, Murali D, Barnhart TE, Thio JP, Bajwa AK, Bonab AA, Normandin MD, Schneider ML, Mukherjee J, Christian BT. (2014) Initial in vivo PET imaging of 5-HT1A receptors with 3-[(18)F]mefway. American Journal of Nuclear Medicine and Molecular Imaging. 15;4(5):483-9.

Li CT, Palotti M, Holden JE, Oh J, Okonkwo O, Christian BT, Bendlin BB, Buyan-Dent L, Harding SJ, Stone CK, DeJesus OT, Nickles RJ, Gallagher CL. (2014) A dual-tracer study of extrastriatal 6-[18F]fluoro-m-tyrosine and 6-[18F]-fluoro-L-dopa uptake in Parkinson’s disease. Synapse. 68(8):325-31.

Hillmer AT, Tudorascu DL, Wooten DW, Lao PJ, Barnhart TE, Ahlers EO, Resch LM, Larson JA, Converse AK, Moore CF, Schneider ML, Christian BT. (2014) Changes in the α4β2* nicotinic acetylcholine system during chronic controlled alcohol exposure in nonhuman primates. Drug and Alcohol Dependence. 138:216-9.

Tomer R, Slagter HA, Christian BT, Fox AS, King CR, Murali D, Gluck MA, Davidson RJ. (2014) Love to win or hate to Lose? Asymmetry of dopamine D2 receptor binding predicts sensitivity to reward versus punishment. Journal of Cognitive Neuroscience. 26(5):1039-48.

Wooten DW, Hillmer AT, Moirano JM, Tudorascu DL, Ahlers EO, Slesarev MS, Barnhart TE, Mukherjee J, Schneider ML, Christian BT. (2013) 5-HT1A sex based differences in Bmax, in vivo KD, and BPND in the nonhuman primate. NeuroImage. 15;77:125-32.

Tomer R, Slagter HA, Christian BT, Fox AS, King CR, Murali D, Davidson RJ. (2013) Dopamine asymmetries predict orienting bias in healthy individuals. Cerebral Cortex. 23(12):2899-904.

Christian BT, Wooten DW, Hillmer AT, Tudorascu DL, Converse AK, Moore CF, Ahlers EO, Barnhart TE, Kalin NH, Barr CS, Schneider ML. (2013) Serotonin transporter genotype affects serotonin 5-HT1A binding in primates. Journal of Neuroscience. 6;33(6):2512-6.

Converse AK, Moore CF, Moirano JM, Ahlers EO, Larson JA, Engle JW, Barnhart TE, Murali D, Christian BT, Dejesus OT, Holden JE, Nickles RJ, Schneider ML. (2013) Prenatal Stress Induces Increased Striatal Dopamine Transporter Binding in Adult Nonhuman Primates. Biological Psychiatry. 1;74(7):502-10.

Murali D, Barnhart TE, Vandehey NT, Christian BT, Nickles RJ, Converse AK, Larson JA, Holden JE, Schneider ML, Dejesus OT. (2013) An efficient synthesis of dopamine transporter tracer [¹⁸F]FECNT. Applied Radiation and Isotopes. 72:128-32.

Hillmer AT, Wooten DW, Slesarev MS, Ahlers EO, Barnhart TE, Schneider ML, Mukherjee J, Christian BT. (2013) Measuring α4β2* nicotinic acetylcholine receptor density in vivo with [(18)F]nifene PET in the nonhuman primate. Journal of Cerebral Blood Flow & Metabolism. 33(11):1806-14.

Hillmer AT, Wooten DW, Slesarev MS, Ahlers EO, Barnhart TE, Murali D, Schneider ML, Mukherjee J, Christian BT. (2012) PET Imaging of α4β2* Nicotinic Acetylcholine Receptors: Qualitative Analysis of 18F-Nifene Kinetics in the Nonhuman Primate. Journal of Nuclear Medicine, 53(9):1471-80. doi: 10.2967/jnumed.112.103846.

Wooten DW, Hillmer AT, Moirano JM, Ahlers EO, Slesarev M, Barnhart TE, Mukherjee J, Schneider ML, Christian BT. (2012) Measurement of 5-HT(1A) receptor density and in-vivo binding parameters of [(18)F]mefway in the nonhuman primate. Journal of Cerebral Blood Flow & Metabolism. 2012 Apr 4 [Epub ahead of print].

Slagter HA, Tomer R, Christian BT, Fox AS, Colzato LS, King CR, Murali D, Davidson RJ. (2012) PET evidence for a role for striatal dopamine in the attentional blink: functional implications. Journal of Cognitive Neuroscience. 24(9):1932-40.

Hillmer AT, Wooten DW, Moirano JM, Slesarev M, Barnhart TE, Engle JW, Nickles RJ, Murali D, Schneider ML, Mukherjee J, Christian BT. (2011) Specific α4β2 nicotinic acetylcholine receptor binding of [F-18]nifene in the rhesus monkey. Synapse. Dec;65(12):1309-18.

Wooten D, Hillmer A, Murali D, Barnhart T, Schneider ML, Mukherjee J, Christian BT. (2011) An in vivo comparison of cis- and trans-[18F]mefway in the nonhuman primate. Nuclear Medicine and Biology. 38(7):925-32.

Bartlett RM, Dejesus OT, Barnhart TE, Nickles RJ, Christian BT, Graner JL, Holden JE. (2010) Fetal dopamine receptor characteristics assessed in utero. Journal of Cerebral Blood Flow & Metabolism. 30(8):1437-40.

Vandehey NT, Moirano JM, Converse AK, Holden JE, Mukherjee J, Murali D, Nickles RJ, Davidson RJ, Schneider ML, Christian BT. (2010) High-affinity dopamine D-2/D-3 PET radioligands F-18-fallypride and C-11-FLB457: A comparison of kinetics in extrastriatal regions using a multiple-injection protocol. Journal of Cerebral Blood Flow & Metabolism. 30(5):994-1007.

Christian BT, Vandehey NT, Floberg JM, Mistretta CA. (2010) Dynamic PET denoising with HYPR processing. Journal of Nuclear Medicine. 51(7):1147-54.

Oler JA, Fox AS, Shelton SE, Christian BT, Murali D, Oakes TR, Davidson RJ, Kalin NH. (2009) Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity. Journal of Neuroscience. 12;29(32):9961-6.

Christian BT, Vandehey NT, Fox AS, Murali D, Oakes TR, Converse AK, Nickles RJ, Shelton SE, Davidson RJ and Kalin NH. (2009) The distribution of D2/D3 receptor binding in the adolescent rhesus monkey using small animal PET imaging. Neuroimage. 44:1334-1344.

Vandehey NT, Garell PC, Hampel JA, Murali D, Smith EM, Davidson R, Converse AK, Nickles RJ and Christian BT. (2009) PET measurement of changes in D2/D3 dopamine receptor binding in a nonhuman primate during chronic deep brain stimulation of the bed nucleus of the stria terminalis. Journal of Neuroscience Methods. 176:129- 135.

Christian BT, Fox AS, Oler JA, Vandehey NT, Murali D, Rogers J, Oakes TR, Shelton SE, Davidson RJ, Kalin NH. (2009) Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET. Neuroimage. Oct 1;47(4):1230-6.

Bradley T Christian, PhD

Contact Information

Research Statement

Selected Publications