Doug Dean III, PhD
Position title: Assistant Professor, Pediatrics, Medical Physics
PhD, Brown University
Assistant Professor, Pediatrics
Contact Information
Waisman Center
1500 Highland Avenue
Room T135
Madison, WI 53705
608-262-6706
deaniii@wisc.edu
Developing Brain Imaging Lab
Research Statement
Doug’s research focuses on the development and application of novel quantitative magnetic resonance imaging (MRI) methods to measure and evaluate the brain structure throughout early neurodevelopment and aging. He is particularly experienced in pediatric imaging, scanning more than 800 infants and young children (3 months to 12 years) during his graduate work. His current research is focused on examining how the white matter microstructure of the brain develops across the early development and how these microstructural processes are related to changes in cognition and behavior.
Selected Publications
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Surgent, O., Guerrero-Gonzalez, J., Dean, D. C., 3rd, Adluru, N., Kirk, G. R., Kecskemeti, S. R., Alexander, A. L., Li, J. J., & Travers, B. G. (2024). Microstructural neural correlates of maximal grip strength in autistic children: the role of the cortico-cerebellar network and attention-deficit/hyperactivity disorder features. Frontiers in integrative neuroscience, 18, 1359099. https://doi.org/10.3389/fnint.2024.1359099
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Travers, B. G., Surgent, O., Guerrero-Gonzalez, J., Dean, D. C., 3rd, Adluru, N., Kecskemeti, S. R., Kirk, G. R., Alexander, A. L., Zhu, J., Skaletski, E. C., Naik, S., & Duran, M. (2024). Role of autonomic, nociceptive, and limbic brainstem nuclei in core autism features. Autism research : official journal of the International Society for Autism Research, 17(2), 266–279. https://doi.org/10.1002/aur.3096
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Cho, J., Gagoski, B., Kim, T. H., Wang, F., Manhard, M. K., Dean, D., 3rd, Kecskemeti, S., Caprihan, A., Lo, W. C., Splitthoff, D. N., Liu, W., Polak, D., Cauley, S., Setsompop, K., Grant, P. E., & Bilgic, B. (2023). Time-efficient, high-resolution 3T whole-brain relaxometry using 3D-QALAS with wave-CAIPI readouts. Magnetic resonance in medicine, 10.1002/mrm.29865. Advance online publication. https://doi.org/10.1002/mrm.29865
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DiPiero, M., Cordash, H., Prigge, M. B., King, C. K., Morgan, J., Guerrero-Gonzalez, J., Adluru, N., King, J. B., Lange, N., Bigler, E. D., Zielinski, B. A., Alexander, A. L., Lainhart, J. E., & Dean, D. C., 3rd (2023). Tract- and gray matter- based spatial statistics show white matter and gray matter microstructural differences in autistic males. Frontiers in neuroscience, 17, 1231719. https://doi.org/10.3389/fnins.2023.1231719
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Surgent, O., Guerrero-Gonzalez, J., Dean, D. C., 3rd, Kirk, G. R., Adluru, N., Kecskemeti, S. R., Alexander, A. L., & Travers, B. G. (2023). How we get a grip: Microstructural neural correlates of manual grip strength in children. NeuroImage, 273, 120117. https://doi.org/10.1016/j.neuroimage.2023.120117
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Nair, A. K., Van Hulle, C. A., Bendlin, B. B., Zetterberg, H., Blennow, K., Wild, N., Kollmorgen, G., Suridjan, I., Busse, W. W., Dean, D. C., 3rd, & Rosenkranz, M. A. (2023). Impact of asthma on the brain: evidence from diffusion MRI, CSF biomarkers and cognitive decline. Brain communications, 5(3), fcad180. https://doi.org/10.1093/braincomms/fcad180
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Planalp, E. M., Dowe, K. N., Alexander, A. L., Goldsmith, H. H., Davidson, R. J., & Dean, D. C., 3rd (2023). White matter microstructure predicts individual differences in infant fear (But not anger and sadness). Developmental Science, 26(3), e13340. https://doi.org/10.1111/desc.13340
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DiPiero, M. A., Surgent, O. J., Travers, B. G., Alexander, A. L., Lainhart, J. E., & Dean Iii, D. C. (2023). Gray matter microstructure differences in autistic males: A gray matter based spatial statistics study. NeuroImage. Clinical, 37, 103306. https://doi.org/10.1016/j.nicl.2022.103306
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Surgent, O., Riaz, A., Ausderau, K. K., Adluru, N., Kirk, G. R., Guerrero-Gonzalez, J., Skaletski, E. C., Kecskemeti, S. R., Dean Iii, D. C., Weismer, S. E., Alexander, A. L., & Travers, B. G. (2022). Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children. Molecular autism, 13(1), 48. https://doi.org/10.1186/s13229-022-00524-3
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Moody, J. F., Dean, D. C., 3rd, Kecskemeti, S. R., Blennow, K., Zetterberg, H., Kollmorgen, G., Suridjan, I., Wild, N., Carlsson, C. M., Johnson, S. C., Alexander, A. L., & Bendlin, B. B. (2022). Associations between diffusion MRI microstructure and cerebrospinal fluid markers of Alzheimer’s disease pathology and neurodegeneration along the Alzheimer’s disease continuum. Alzheimer’s & dementia (Amsterdam, Netherlands), 14(1), e12381. https://doi.org/10.1002/dad2.12381
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Birn, R. M., Dean, D. C., 3rd, Wooten, W., Planalp, E. M., Kecskemeti, S., Alexander, A. L., Goldsmith, H. H., & Davidson, R. J. (2022). Reduction of motion artifacts in functional connectivity resulting from infrequent large motion. Brain Connectivity, 12(8), 740–753. https://doi.org/10.1089/brain.2021.0133
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Prigge, M., Bigler, E. D., Lange, N., Morgan, J., Froehlich, A., Freeman, A., Kellett, K., Kane, K. L., King, C. K., Taylor, J., Dean, D. C., 3rd, King, J. B., Anderson, J. S., Zielinski, B. A., Alexander, A. L., & Lainhart, J. E. (2022). Longitudinal stability of intellectual functioning in autism spectrum disorder: From age 3 through mid-adulthood. Journal of Autism and Developmental Disorders, 52(10), 4490–4504. https://doi.org/10.1007/s10803-021-05227-x
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Knussmann, G. N., Anderson, J. S., Prigge, M., Dean, D. C., 3rd, Lange, N., Bigler, E. D., Alexander, A. L., Lainhart, J. E., Zielinski, B. A., & King, J. B. (2022). Test-retest reliability of FreeSurfer-derived volume, area and cortical thickness from MPRAGE and MP2RAGE brain MRI images. Neuroimage. Reports, 2(2), 100086. https://doi.org/10.1016/j.ynirp.2022.100086
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Ozaydin, B., Bicki, E., Taparli, O. E., Sheikh, T. Z., Schmidt, D. K., Yapici, S., Hackett, M. B., Karahan-Keles, N., Eickhoff, J. C., Corcoran, K., Lagoa-Miguel, C., Guerrero Gonzalez, J., Dean Iii, D. C., Sousa, A. M. M., Ferrazzano, P. A., Levine, J. E., & Cengiz, P. (2022). Novel Injury Scoring Tool for Assessing Brain Injury following Neonatal Hypoxia-Ischemia in Mice. Developmental neuroscience, 44(4-5), 394–411. https://doi.org/10.1159/000525244
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Moody, J. F., Aggarwal, N., Dean, D. C., 3rd, Tromp, D., Kecskemeti, S. R., Oler, J. A., Kalin, N. H., & Alexander, A. L. (2022). Longitudinal assessment of early-life white matter development with quantitative relaxometry in nonhuman primates. NeuroImage, 251, 118989. https://doi.org/10.1016/j.neuroimage.2022.118989
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Saiote, C., Sutter, E., Xenopoulos-Oddsson, A., Rao, R., Georgieff, M., Rudser, K., Peyton, C., Dean, D., McAdams, R. M., & Gillick, B. (2022). Study Protocol: Multimodal Longitudinal Assessment of Infant Brain Organization and Recovery in Perinatal Brain Injury. Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association, 34(2), 268–276. https://doi.org/10.1097/PEP.0000000000000886
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Pedersen, W. S., Dean, D. C., Adluru, N., Gresham, L. K., Lee, S. D., Kelly, M. P., Mumford, J. A., Davidson, R. J., & Schaefer, S. M. (2022). Individual variation in white matter microstructure is related to better recovery from negative stimuli. Emotion (Washington, D.C.), 22(2), 244–257. https://doi.org/10.1037/emo0000996
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Guerrero-Gonzalez, J., Surgent, O., Adluru, N., Kirk, G. R., Dean Iii, D. C., Kecskemeti, S. R., Alexander, A. L., & Travers, B. G. (2022). Improving Imaging of the Brainstem and Cerebellum in Autistic Children: Transformation-Based High-Resolution Diffusion MRI (TiDi-Fused) in the Human Brainstem. Frontiers in integrative neuroscience, 16, 804743. https://doi.org/10.3389/fnint.2022.804743
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Rosenkranz, M. A., Dean, D. C., 3rd, Bendlin, B. B., Jarjour, N. N., Esnault, S., Zetterberg, H., Heslegrave, A., Evans, M. D., Davidson, R. J., & Busse, W. W. (2022). Neuroimaging and biomarker evidence of neurodegeneration in asthma. The Journal of allergy and clinical immunology, 149(2), 589–598.e6. https://doi.org/10.1016/j.jaci.2021.09.010
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Song, Y., Lally, P. J., Yanez Lopez, M., Oeltzschner, G., Nebel, M. B., Gagoski, B., Kecskemeti, S., Hui, S., Zöllner, H. J., Shukla, D., Arichi, T., De Vita, E., Yedavalli, V., Thayyil, S., Fallin, D., Dean, D. C., 3rd, Grant, P. E., Wisnowski, J. L., & Edden, R. (2022). Edited magnetic resonance spectroscopy in the neonatal brain. Neuroradiology, 64(2), 217–232. https://doi.org/10.1007/s00234-021-02821-9
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Luo, Z., Adluru, N., Dean, D. C., 3rd, Alexander, A. L., & Goldsmith, H. H. (2022). Genetic and environmental influences of variation in diffusion MRI measures of white matter microstructure. Brain structure & function, 227(1), 131–144. https://doi.org/10.1007/s00429-021-02393-7
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Bazydlo, A. M., Zammit, M. D., Wu, M., Lao, P. J., Dean, D. C., 3rd, Johnson, S. C., Tudorascu, D. L., Cohen, A., Cody, K. A., Ances, B., Laymon, C. M., Klunk, W. E., Zaman, S., Handen, B. L., Hartley, S. L., Alexander, A. L., & Christian, B. T. (2022). White matter microstructure associations to amyloid burden in adults with Down syndrome. NeuroImage. Clinical, 33, 102908. https://doi.org/10.1016/j.nicl.2021.102908
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Vogt, N. M., Hunt, J., Adluru, N., Ma, Y., Van Hulle, C. A., Doug III, D., Kecskemeti, S. R., Chin, N. A., Carlsson, C. M., Asthana, S., Johnson, S. C., Kollmorgen, G., Batrla, R., Wild, N., Buck, K., Zetterberg, H., Alexander, A. L., Blennow, K., & Bendlin, B. B. (2022). Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults. Alzheimer’s & dementia: the journal of the Alzheimer’s Association, 18(1):65-76. doi: 10.1002/alz.12364.
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Mercer, J. S., Erickson-Owens, D. A., Deoni, S., Dean Iii, D. C., Tucker, R., Parker, A. B., Joelson, S., Mercer, E. N., Collins, J., & Padbury, J. F. (2022). The Effects of Delayed Cord Clamping on 12-Month Brain Myelin Content and Neurodevelopment: A Randomized Controlled Trial. American journal of perinatology, 39(1), 37–44. https://doi.org/10.1055/s-0040-1714258
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Zhou, X., Planalp, E. M., Heinrich, L., Pletcher, C., DiPiero, M., Alexander, A. L., Litovsky, R. Y., & Dean, D. C., 3rd (2022). Inhibitory Control in Children 4-10 Years of Age: Evidence From Functional Near-Infrared Spectroscopy Task-Based Observations. Frontiers in human neuroscience, 15, 798358. DOI: 10.3389/fnhum.2021.798358
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Russell, J. D., Heyn, S. A., Dean, D. C., 3rd, & Herringa, R. J. (2021). Pediatric PTSD is characterized by age- and sex-related abnormalities in structural connectivity. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology, 46(12):2217-2223. https://doi.org/10.1038/s41386-021-01083-6
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Prigge, M., Lange, N., Bigler, E. D., King, J. B., Dean, D. C., 3rd, Adluru, N., Alexander, A. L., Lainhart, J. E., & Zielinski, B. A. (2021). A 16-year study of longitudinal volumetric brain development in males with autism. NeuroImage, 236, 118067. https://doi.org/10.1016/j.neuroimage.2021.118067
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Gajawelli, N., Deoni, S., Ramsy, N., Dean, D. C., 3rd, O’Muircheartaigh, J., Nelson, M. D., Lepore, N., & Coulon, O. (2021). Developmental changes of the central sulcus morphology in young children. Brain structure & function, 226(6), 1841–1853. https://doi.org/10.1007/s00429-021-02292-x
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Dean, D. C., 3rd, Madrid, A., Planalp, E. M., Moody, J. F., Papale, L. A., Knobel, K. M., Wood, E. K., McAdams, R. M., Coe, C. L., Hill Goldsmith, H., Davidson, R. J., Alisch, R. S., & Kling, P. J. (2021). Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety. Scientific reports, 11(1), 12181. https://doi.org/10.1038/s41598-021-91642-0
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Surgent, O., Dean, D. C., Alexander, A. L., Dadalko, O. I., Guerrero-Gonzalez, J., Taylor, D., Skaletski, E., & Travers, B. G. (2021). Neurobiological and behavioural outcomes of biofeedback-based training in autism: a randomized controlled trial. Brain communications, 3(3), fcab112. https://doi.org/10.1093/braincomms/fcab112
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HashemizadehKolowri, S. K., Chen, R. R., Adluru, G., Dean, D. C., Wilde, E. A., Alexander, A. L., & DiBella, E. (2021). Simultaneous multi-slice image reconstruction using regularized image domain split slice-GRAPPA for diffusion MRI. Medical image analysis, 70, 102000. https://doi.org/10.1016/j.media.2021.102000
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Aggarwal, N., Moody, J. F., Dean, D. C., Tromp, D., Kecskemeti, S. R., Oler, J. A., Alexander, A. L., & Kalin, N. H. (2021). Spatiotemporal dynamics of nonhuman primate white matter development during the first year of life. NeuroImage, 231, 117825. https://doi.org/10.1016/j.neuroimage.2021.117825
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Bazydlo, A., Zammit, M., Wu, M., Dean, D., Johnson, S., Tudorascu, D., Cohen, A., Cody, K., Ances, B., Laymon, C., Klunk, W., Zaman, S., Handen, B., Alexander, A., Christian, B., & Hartley, S. (2021). White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study. Journal of neurodevelopmental disorders, 13(1), 17. https://doi.org/10.1186/s11689-021-09366-1
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Remer, J., Dean, D. C., 3rd, Chen, K., Reiman, R. A., Huentelman, M. J., Reiman, E. M., & Deoni, S. (2020). Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein ε4 allele. NeuroImage, 222, 117243. https://doi.org/10.1016/j.neuroimage.2020.117243
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Dowe, K. N., Planalp, E. M., Dean, D. C., 3rd, Alexander, A. L., Davidson, R. J., & Goldsmith, H. H. (2020). Early microstructure of white matter associated with infant attention. Developmental cognitive neuroscience, 45, 100815. https://doi.org/10.1016/j.dcn.2020.100815
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Torres ER, Tumey TA, Dean DC 3rd, Kassahun-Yimer W, Lopez-Lambert ED, Hitchcock ME. (2020). Non-pharmacological strategies to obtain usable magnetic resonance images in non-sedated infants: Systematic review and meta-analysis. International Journal of Nursing Studies, 106:103551. doi: 10.1016/j.ijnurstu.2020.103551. Epub 2020 Feb 22. PMID: 32294563; PMCID: PMC7800149.
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Vogt NM, Hunt JF, Adluru N, Dean DC, Johnson SC, Asthana S, Yu JJ, Alexander AL, Bendlin BB. (2020). Cortical Microstructural Alterations in Mild Cognitive Impairment and Alzheimer’s Disease Dementia. Cerebral Cortex, 30(5):2948-2960. doi: 10.1093/cercor/bhz286.
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Dean DC 3rd, Freeman A, Lainhart J. (2020). The development of the social brain in baby siblings of children with autism. Current Opinion in Psychiatry, 33(2):110-116. doi: 10.1097/YCO.0000000000000572. PMID: 31815759; PMCID: PMC7027937.
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King JB, Prigge MBD, King CK, Morgan J, Weathersby F, Fox JC, Dean DC 3rd, Freeman A, Villaruz JAM, Kane KL, Bigler ED, Alexander AL, Lange N, Zielinski B, Lainhart JE, Anderson JS. (2019). Generalizability and reproducibility of functional connectivity in autism. Molecular Autism, 24;10:27. doi: 10.1186/s13229-019-0273-5.
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LeBourgeois MK, Dean DC, Deoni SCL, Kohler M, Kurth S. (2019). A simple sleep EEG marker in childhood predicts brain myelin 3.5 years later. Neuroimage, 199:342-350. doi: 10.1016/j.neuroimage.2019.05.072.
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Dean DC 3rd, Planalp EM, Wooten W, Kecskemeti SR, Adluru N, Schmidt CK, Frye C, Birn RM, Burghy CA, Schmidt NL, Styner MA, Short SJ, Kalin NH, Goldsmith HH, Alexander AL, Davidson RJ. (2019). Association of Prenatal Maternal Depression and Anxiety Symptoms With Infant White Matter Microstructure. JAMA Pediatrics, 172(10):973-981. PMID: 30177999. PMCID: PMC6190835. DOI: 10.1001/jamapediatrics.2018.2132
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McLaughlin K, Travers BG, Dadalko OI, Dean DC 3rd, Tromp D, Adluru N, Destiche D, Freeman A, Prigge MD, Froehlich A, Duffield TC, Zielinski BA, Bigler ED, Lange N, Anderson JS, Alexander AL, Lainhart JE. (2018). Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder. Autism Research, 11(3):450-462.
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Dean DC 3rd, Planalp EM, Wooten W, Schmidt CK, Kecskemeti SR, Frye C, Schmidt NL, Goldsmith HH, Alexander AL, Davidson RJ. (2018). Investigation of brain structure in the 1-month infant. Brain Structure and Function, 223(4):1953-1970. doi: 10.1007/s00429-017-1600-2.
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Travers BG, Mason AH, Mrotek LA, Ellertson A, Dean DC 3rd, Engel C, Gomez A, Dadalko OI, McLaughlin K. (2018). Biofeedback-Based, Videogame Balance Training in Autism. Journal of Autism and Developmental Disorders, 48(1):163-175.
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Theisen F, Leda R, Pozorski V, Oh JM, Adluru N, Wong R, Okonkwo O, Dean DC 3rd, Bendlin BB, Johnson SC, Alexander AL, Gallagher CL. (2017). Evaluation of striatonigral connectivity using probabilistic tractography in Parkinson’s disease. Neuroimage Clinical, 9;16:557-563. doi: 10.1016/j.nicl.2017.09.009
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Dean DC 3rd, Lange N, Travers BG, Prigge MB, Matsunami N, Kellett KA, Freeman A, Kane KL, Adluru N, Tromp DP, Destiche DJ, Samsin D, Zielinski BA, Fletcher PT, Anderson JS, Froehlich AL, Leppert MF, Bigler ED, Lainhart JE, Alexander AL. (2017). Multivariate characterization of white matter heterogeneity in autism spectrum disorder. NeuroImage: Clinical, 6;14:54-66.
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Dean DC 3rd, Hurley SA, Kecskemeti SR, O’Grady JP, Canda C, Davenport-Sis NJ, Carlsson CM, Zetterberg H, Blennow K, Asthana S, Sager MA, Johnson SC, Alexander AL, Bendlin BB. (2017) Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease. JAMA Neurology, 74(1):41-49. doi: 10.1001/jamaneurol.2016.3232.
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Dean DC 3rd, Sojkova J, Hurley S, Kecskemeti S, Okonkwo O, Bendlin BB, Theisen F, Johnson SC, Alexander AL, Gallagher CL. (2016) Alterations of Myelin Content in Parkinson’s Disease: A Cross-Sectional Neuroimaging Study. PLoS One. 5;11(10):e0163774. doi: 10.1371/journal.pone.0163774.
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Merluzzi AP, Dean DC 3rd, Adluru N, Suryawanshi GS, Okonkwo OC, Oh JM, Hermann BP, Sager MA, Asthana S, Zhang H, Johnson SC, Alexander AL, Bendlin BB. (2016) Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging. Neurobiology of Aging. 43:79-88. doi: 10.1016/j.neurobiolaging.2016.03.026.
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Dean DC 3rd, Travers BG, Adluru N, Tromp do PM, Destiche DJ, Samsin D, Prigge MB, Zielinski BA, Fletcher PT, Anderson JS, Froehlich AL, Bigler ED, Lange N, Lainhart JE, Alexander AL. (2016) Investigating the Microstructural Correlation of White Matter in Autism Spectrum Disorder. Brain Connectivity, 6(5):415-33.
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Dean DC 3rd, O’Muircheartaigh J, Dirks H, Travers BG, Adluru N, Alexander AL, Deoni SCL. (2016). Mapping an index of the myelin g-ratio in infants using magnetic resonance imaging. Neuroimage, 15;132:225-237.