Sunduz Keles, PhD

Position title: Professor, Statistics and Biostatistics & Medical Informatics

PhD, University of California, Berkeley

Contact Information

UW-Madison
K6/440 Clinical Sciences Center
600 Highland Avenue
Madison, WI 53792-4675
608.263.4533
keles@stat.wisc.edu
Keles Research Group

Research Statement

I am interested in statistical and computational genomics. Our research concerns developing and applying statistical methods for problems that arise in genome biology.

Selected Publications

Huang, K., Wu, Y., Shin, J., Zheng, Y., Siahpirani, A. F., Lin, Y., Ni, Z., Chen, J., You, J., Keles, S., Wang, D., Roy, S., & Lu, Q. (2021). Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder. PLoS genetics, 17(2), e1009309. https://doi.org/10.1371/journal.pgen.1009309
Kreimer A, Zeng H, Edwards MD, Guo Y, Tian K, Shin S, Welch R, Wainberg M, Mohan R, Sinnott-Armstrong NA, Li Y, Eraslan G, Amin TB, Goke J, Mueller NS, Kellis M, Kundaje A, Beer MA, Keles S, Gifford DK, Yosef N. (2017) Predicting gene expression in massively parallel reporter assays: A comparative study. Human Mutations, 38(9):1240-1250. doi: 10.1002/humu.23197.
Li R, Dong Q, Yuan X, Zeng X, Gao Y, Chiao C, Li H, Zhao X, Keles S, Wang Z, Chang Q. (2016) Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome. PLoS Genetics. 28;12(6):e1006129. doi: 10.1371/journal.pgen.
Liu P, Sanalkumar R, Bresnick EH, Keleş S, Dewey CN. (2016) Integrative analysis with ChIP-seq advances the limits of transcript quantification from RNA-seq. Genome Research. 26(8):1124-33. doi: 10.1101/gr.199174.
Papale LA, Li S, Madrid A, Zhang Q, Chen L, Chopra P, Jin P, Keleş S, Alisch RS. (2016) Sex-specific hippocampal 5-hydroxymethylcytosine is disrupted in response to acute stress. Neurobiology of Disease. 96:54-66. doi: 10.1016/j.nbd.2016.08.014.
Capowski EE, Wright LS, Phillips MJ, Wallace K, Petelinsek A, Hagstrom A, Pinilla I, Borys K, Lien J, Min JH, Keles S, Thomson JA, Gamm DM, Liang K. (2016) Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells. Stem Cells, 34(11):2625-2634. doi: 10.1002/stem.2414.
Lopez-Anido C, Sun G, Koenning M, Srinivasan R, Hung HA, Emery B, Keles S, Svaren J. (2015) Differential Sox10 genomic occupancy in myelinating glia. Glia, 63:1897–1914. doi: 10.1002/glia.22855.
Hung HA, Sun G, Keles S, Svaren J. (2015) Dynamic regulation of Schwann cell enhancers after peripheral nerve injury. Journal of Biological Chemistry, 13;290(11):6937-50. doi: 10.1074/jbc.M114.622878.
Sun G, Srinivasan R, Lopez-Anido C, Hung HA, Svaren J, Keleş S. (2014) In Silico Pooling of ChIP-seq Control Experiments. PLoS One. 9(11):e109691.
Myers KS, Yan H, Ong IM, Chung D, Liang K, Tran F, Keleş S, Landick R, Kiley PJ. (2013) Genome-scale Analysis of Escherichia coli FNR Reveals Complex Features of Transcription Factor Binding. PLoS Genetics. 9(6):e1003565.
Yang X, Qiao D, Meyer K, Pier T, Keles S, Friedl A. (2012) Angiogenesis induced by signal transducer and activator of transcription 5A (STAT5A) is dependent on autocrine activity of proliferin. The Journal of Biological Chemistry. Feb 24;287(9):6490-502.
Jones EA, Brewer MH, Srinivasan R, Krueger C, Sun G, Charney KN, Keles S, Antonellis A, Svaren J. (2012) Distal enhancers upstream of the Charcot-Marie-Tooth type 1A disease gene PMP22. Human Molecular Genetics. Apr 1;21(7):1581-91.
Srinivasan R, Sun G, Keles S, Jones EA, Jang SW, Krueger C, Moran JJ, Svaren J. (2012) Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve. Nucleic Acids Research. 40(14):6449-60.