James J. Li, PhD
Assistant Professor, Psychology
PhD, University of California, Los Angeles
My lab investigates genetic and environmental factors that contribute to the development of child externalizing disorders (e.g., attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder). Research in my lab utilizes molecular genetic approaches (e.g., genome-wide association scans, gene-pathway analysis) to advance understanding about the genetic architecture underlying complex developmental phenomena. We also focus on rigorous measurement of early environmental influences as they relate to child behavioral problems, not only for risk factors such as negative parenting and maltreatment, but also for enriched factors such as positive parenting and social support. The goal of this research is to understand how genes and environments independently and interactively influence variation in child social and behavioral development, and to ultimately bridge the substantial gap between genetics/neuroscience and prevention/intervention.
Li JJ, Lee SS. (2010) Latent class analysis of antisocial behavior: interaction of serotonin transporter genotype and maltreatment. Journal of Abnormal Child Psychology. 38(6):789-801. doi: 10.1007/s10802-010-9409-y.
Li JJ, Lee SS. (2012) Association of positive and negative parenting behavior with childhood ADHD: interactions with offspring monoamine oxidase A (MAO-A) genotype. Journal of Abnormal Child Psychology. 40(2):165-75. doi: 10.1007/s10802-011-9553-z.
Li JJ, Lee SS. (2013) Interaction of dopamine transporter gene and observed parenting behaviors on attention-deficit/hyperactivity disorder: a structural equation modeling approach. Journal of Clinical Child & Adolescent Psychology. 42(2):174-86. doi: 10.1080/15374416.2012.736355.
Li JJ, Berk MS, Lee SS. (2013) Differential susceptibility in longitudinal models of gene-environment interaction for adolescent depression. Development and Psychopathology. 25(4 Pt 1):991-1003. doi: 10.1017/S0954579413000321.
Li JJ, Lee SS. (2014) Negative emotionality mediates the association of 5-HTTLPR genotype and depression in children with and without ADHD. Psychiatry Research. 30;215(1):163-9. doi: 10.1016/j.psychres.
Li JJ, Reise SP, Chronis-Tuscano A, Mikami AY, Lee SS. (2015) Item Response Theory Analysis of ADHD Symptoms in Children With and Without ADHD. Assessment. In Press.
Li JJ, Chung TA, Vanyukov MM, Scott Wood D, Ferrell R, Clark DB. (2015) A Hierarchical Factor Model of Executive Functions in Adolescents: Evidence of Gene-Environment Interplay. Journal of the International Neuropsychological Society. 21(1), 62-73. doi:http://dx.doi.org/10.1017/S1355617714001039.