Robert A. Pearce, MD, PhD

Position title: Professor, Anesthesiology

MD, PhD – University of Virginia-Charlottesville

Contact Information

University of Wisconsin
(608) 263-0208
rapearce@wisc.edu
Pearce Lab

Research Statement

Research in my laboratory is focused on understanding how anesthetics and other drugs that target GABA receptors control memory formation and consciousness. Using expressed recombinant receptors, hippocampal brain slice preparations, and multichannel in vivo recordings from the hippocampus, we are investigating how inhibitory circuits support and control network activity. We are particularly interested in identifying the molecular components and functional properties of different types of inhibitory synapses that are found on the dendrites of pyramidal neurons and interneurons, and in determining their roles in generating or controlling complex circuit responses, such as theta and gamma oscillations, and in regulating synaptic plasticity.

Selected Publications

Gjini, K., Casey, C., Kunkel, D., Her, M., Banks, M. I., Pearce, R. A., Lennertz, R., & Sanders, R. D. (2023). Delirium is associated with loss of feedback cortical connectivity. Alzheimer’s & dementia, 10.1002/alz.13471. Advance online publication. https://doi.org/10.1002/alz.13471
Rigby, M. J., Orefice, N. S., Lawton, A. J., Ma, M., Shapiro, S. L., Yi, S. Y., Dieterich, I. A., Frelka, A., Miles, H. N., Pearce, R. A., Yu, J., Li, L., Denu, J. M., & Puglielli, L. (2022). Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology. Brain : a journal of neurology, 145(2), 500–516. https://doi.org/10.1093/brain/awab295
Rigby, M. J., Orefice, N. S., Lawton, A. J., Ma, M., Shapiro, S. L., Yi, S. Y., Dieterich, I. A., Frelka, A., Miles, H. N., Pearce, R. A., Yu, J., Li, L., Denu, J. M., & Puglielli, L. (2022). SLC13A5/sodium-citrate co-transporter overexpression causes disrupted white matter integrity and an autistic-like phenotype. Brain communications, 4(1), fcac002. https://doi.org/10.1093/braincomms/fcac002
Parks CL, Tucker W, Amlong CA, Mecozzi S, Pearce RA. (2016) Lipid-free Fluoropolymer-based Propofol Emulsions and Lipid Reversal of Propofol Anesthesia in Rats. Anesthesiology. 124(6):1328-37. doi: 10.1097/ALN.0000000000001080.
Amlong CA, Perkins MG, Houle TT, Miller KW, Pearce RA. (2016) Contrasting Effects of the γ-Aminobutyric Acid Type A Receptor β3 Subunit N265M Mutation on Loss of Righting Reflexes Induced by Etomidate and the Novel Anesthetic Barbiturate R-mTFD-MPAB. Anesthesia & Analgesia. 123(5):1241-1246.
Zarnowska ED, Rodgers FC, Oh I, Rau V, Lor C, Laha KT, Jurd R, Rudolph U, Eger EI 2nd, Pearce RA. (2015) Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor. Neuropharmacology, 93, 171–178. https://doi.org/10.1016/j.neuropharm.2015.01.011
Balakrishnan S, Pearce RA. (2015) Spatiotemporal characteristics and pharmacological modulation of multiple gamma oscillations in the CA1 region of the hippocampus. Frontiers in neural circuits, 8, 150. https://doi.org/10.3389/fncir.2014.00150
Engin E, Zarnowska ED, Benke D, Tsvetkov E, Sigal M, Keist R, Bolshakov VY, Pearce RA, Rudolph U. (2015) Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference. Journal of Neuroscience. 7;35(40):13698-712. doi: 10.1523/JNEUROSCI.1370-15.2015.
Rodgers FC, Zarnowska ED, Laha KT, Engin E, Zeller A, Keist R, Rudolph U, Pearce RA. (2015) Etomidate impairs long-term potentiation in vitro by targeting α5-GABAARs on non-pyramidal cells. Journal of Neuroscience. 1;35(26):9707-16. doi: 10.1523/JNEUROSCI.0315-15.2015.