SCRP Publications

Yan, Y., Li, X., Gao, Y., Mathivanan, S., Kong, L., Tao, Y., Dong, Y., Li, X., Bhattacharyya, A., Zhao, X., & Zhang, S. C. (2024). 3D bioprinting of human neural tissues with functional connectivity. Cell stem cell, 31(2), 260–274.e7. https://doi.org/10.1016/j.stem.2023.12.009

Majumder, J., Torr, E. E., Aisenbrey, E. A., Lebakken, C. S., Favreau, P. F., Richards, W. D., Yin, Y., Chang, Q., & Murphy, W. L. (2024). Human induced pluripotent stem cell-derived planar neural organoids assembled on synthetic hydrogels. Journal of tissue engineering, 15, 20417314241230633. https://doi.org/10.1177/20417314241230633

Scandella, V., Petrelli, F., Moore, D. L., Braun, S. M. G., & Knobloch, M. (2023). Neural stem cell metabolism revisited: a critical role for mitochondria. Trends in endocrinology and metabolism: TEM, 34(8), 446–461. https://doi.org/10.1016/j.tem.2023.05.008

Lear, B. P., & Moore, D. L. (2023). Moving CNS axon growth and regeneration research into human model systems. Frontiers in neuroscience, 17, 1198041. https://doi.org/10.3389/fnins.2023.1198041

Ludwig, A. L., Mayerl, S. J., Gao, Y., Banghart, M., Bacig, C., Fernandez Zepeda, M. A., Zhao, X., & Gamm, D. M. (2023). Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures. Proceedings of the National Academy of Sciences of the United States of America, 120(2), e2213418120. https://doi.org/10.1073/pnas.2213418120

Saha K. (2023). Accounting for diversity in the design of CRISPR-based therapeutic genome editing. Nature Genetics, 55(1), 6–7. https://doi.org/10.1038/s41588-022-01272-z

Mayerl, S. J., Bajgai, S., Ludwig, A. L., Jager, L. D., Williams, B. N., Bacig, C., Stoddard, C., Sinha, D., Philpot, B. D., & Gamm, D. M. (2022). Human retinal organoids harboring IMPG2 mutations exhibit a photoreceptor outer segment phenotype that models advanced retinitis pigmentosa. Stem cell reports, 17(11), 2409–2420. https://doi.org/10.1016/j.stemcr.2022.09.004

Giffin-Rao, Y., Sheng, J., Strand, B., Xu, K., Huang, L., Medo, M., Risgaard, K. A., Dantinne, S., Mohan, S., Keshan, A., Daley, R. A., Jr, Levesque, B., Amundson, L., Reese, R., Sousa, A., Tao, Y., Wang, D., Zhang, S. C., & Bhattacharyya, A. (2022). Altered patterning of trisomy 21 interneuron progenitors. Stem cell reports, 17(6), 1366–1379. https://doi.org/10.1016/j.stemcr.2022.05.001

Saha, A., Capowski, E., Fernandez Zepeda, M. A., Nelson, E. C., Gamm, D. M., & Sinha, R. (2022). Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea. Cell stem cell, 29(3), 460–471.e3. https://doi.org/10.1016/j.stem.2022.01.002

Murie, M., Peng, Y., Rigby, M. J., Dieterich, I. A., Farrugia, M. A., Endresen, A., Bhattacharyya, A., & Puglielli, L. (2022). ATase inhibition rescues age-associated proteotoxicity of the secretory pathway. Communications biology, 5(1), 173. https://doi.org/10.1038/s42003-022-03118-0

Tey, S. R., Mueller, M., Reilly, M., Switalski, C., Robertson, S., Sakanaka-Yokoyama, M., & Suzuki, M. (2022). Cell Surface Proteins for Enrichment and In Vitro Characterization of Human Pluripotent Stem Cell-Derived Myogenic Progenitors. Stem cells international, 2022, 2735414. https://doi.org/10.1155/2022/2735414

Fathi, A., Mathivanan, S., Kong, L., Petersen, A. J., Harder, C., Block, J., Miller, J. M., Bhattacharyya, A., Wang, D., & Zhang, S. C. (2022). Chemically induced senescence in human stem cell-derived neurons promotes phenotypic presentation of neurodegeneration. Aging cell, 21(1), e13541. https://doi.org/10.1111/acel.13541

Hunt, J., Li, M., Risgaard, R., Ananiev, G. E., Wildman, S., Zhang, F., Bugni, T. S., Zhao, X., & Bhattacharyya, A. (2021). High Throughput Small Molecule Screen for Reactivation of FMR1 in Fragile X Syndrome Human Neural Cells. Cells, 11(1), 69. https://doi.org/10.3390/cells11010069

Wahlin, K. J., Cheng, J., Jurlina, S. L., Jones, M. K., Dash, N. R., Ogata, A., Kibria, N., Ray, S., Eldred, K. C., Kim, C., Heng, J. S., Phillips, J., Johnston, R. J., Jr, Gamm, D. M., Berlinicke, C., & Zack, D. J. (2021). CRISPR Generated SIX6 and POU4F2 Reporters Allow Identification of Brain and Optic Transcriptional Differences in Human PSC-Derived Organoids. Frontiers in cell and developmental biology, 9, 764725. https://doi.org/10.3389/fcell.2021.764725

Lynch, E. M., Robertson, S., FitzGibbons, C., Reilly, M., Switalski, C., Eckardt, A., Tey, S. R., Hayakawa, K., & Suzuki, M. (2021). Transcriptome analysis using patient iPSC-derived skeletal myocytes: Bet1L as a new molecule possibly linked to neuromuscular junction degeneration in ALS. Experimental neurology, 345, 113815. https://doi.org/10.1016/j.expneurol.2021.113815

Keen, K. L., Petersen, A. J., Figueroa, A. G., Fordyce, B. I., Shin, J., Yadav, R., Erdin, S., Pearce, R. A., Talkowski, M. E., Bhattacharyya, A., & Terasawa, E. (2021). Physiological Characterization and Transcriptomic Properties of GnRH Neurons Derived From Human Stem Cells. Endocrinology, 162(9), bqab120. https://doi.org/10.1210/endocr/bqab120

Morrow, C. S., Porter, T. J., & Moore, D. L. (2021). Fluorescent tagging of endogenous proteins with CRISPR/Cas9 in primary mouse neural stem cells. STAR protocols, 2(3), 100744. https://doi.org/10.1016/j.xpro.2021.100744

Tang, X. Y., Xu, L., Wang, J., Hong, Y., Wang, Y., Zhu, Q., Wang, D., Zhang, X. Y., Liu, C. Y., Fang, K. H., Han, X., Wang, S., Wang, X., Xu, M., Bhattacharyya, A., Guo, X., Lin, M., & Liu, Y. (2021). DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome. The Journal of clinical investigation, 131(12), e135763. https://doi.org/10.1172/JCI135763

Anderson, N. C., Chen, P. F., Meganathan, K., Afshar Saber, W., Petersen, A. J., Bhattacharyya, A., Kroll, K. L., Sahin, M., & Cross-IDDRC Human Stem Cell Working Group (2021). Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders. Stem cell reports, 16(6), 1446–1457. https://doi.org/10.1016/j.stemcr.2021.03.025

Bin Imtiaz, M. K., Jaeger, B. N., Bottes, S., Machado, R. A. C., Vidmar, M., Moore, D. L., & Jessberger, S. (2021). Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity. Cell stem cell, 28(5), 967–977.e8. https://doi.org/10.1016/j.stem.2021.01.015

Aghayee, A., & Ashton, R. (2021). Methods for Controlled Induction of Singular Rosette Cytoarchitecture Within Human Pluripotent Stem Cell-Derived Neural Multicellular Assemblies. Methods in molecular biology (Clifton, N.J.), 2258, 193–203. https://doi.org/10.1007/978-1-0716-1174-6_13

Gong, C., Zheng, X., Guo, F., Wang, Y., Zhang, S., Chen, J., Sun, X., Shah, S., Zheng, Y., Li, X., Yin, Y., Li, Q., Huang, X., Guo, T., Han, X., Zhang, S. C., Wang, W., & Chen, H. (2021). Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury. Cell reports, 34(12), 108889. https://doi.org/10.1016/j.celrep.2021.108889

Xiong, M., Tao, Y., Gao, Q., Feng, B., Yan, W., Zhou, Y., Kotsonis, T. A., Yuan, T., You, Z., Wu, Z., Xi, J., Haberman, A., Graham, J., Block, J., Zhou, W., Chen, Y., & Zhang, S. C. (2021). Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function. Cell stem cell, 28(1), 112–126.e6. https://doi.org/10.1016/j.stem.2020.08.014

Mou, Y., Dong, Y., Chen, Z., Denton, K. R., Duff, M. O., Blackstone, C., Zhang, S. C., & Li, X. J. (2020). Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia. Acta neuropathologica communications, 8(1), 214. https://doi.org/10.1186/s40478-020-01088-0

Tao, Y., Cao, J., Li, M., Hoffmann, B., Xu, K., Chen, J., Lu, X., Guo, F., Li, X., Phillips, M. J., Gamm, D. M., Chen, H., & Zhang, S. C. (2020). PAX6D instructs neural retinal specification from human embryonic stem cell-derived neuroectoderm. EMBO reports, 21(9), e50000. https://doi.org/10.15252/embr.202050000

Aboualizadeh, E., Phillips, M. J., McGregor, J. E., DiLoreto, D. A., Jr, Strazzeri, J. M., Dhakal, K. R., Bateman, B., Jager, L. D., Nilles, K. L., Stuedemann, S. A., Ludwig, A. L., Hunter, J. J., Merigan, W. H., Gamm, D. M., & Williams, D. R. (2020). Imaging Transplanted Photoreceptors in Living Nonhuman Primates with Single-Cell Resolution. Stem cell reports, 15(2), 482–497. https://doi.org/10.1016/j.stemcr.2020.06.019

Sinha, D., Steyer, B., Shahi, P. K., Mueller, K. P., Valiauga, R., Edwards, K. L., Bacig, C., Steltzer, S. S., Srinivasan, S., Abdeen, A., Cory, E., Periyasamy, V., Siahpirani, A. F., Stone, E. M., Tucker, B. A., Roy, S., Pattnaik, B. R., Saha, K., & Gamm, D. M. (2020). Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy. American journal of human genetics, 107(2), 278–292. https://doi.org/10.1016/j.ajhg.2020.06.011

Zhao, X., & Bhattacharyya, A. (2020). Advances in Human Stem Cells and Genome Editing to Understand and Develop Treatment for Fragile X Syndrome. Advances in neurobiology, 25, 33–53. https://doi.org/10.1007/978-3-030-45493-7_2

Shankar, K., Capitini, C. M., & Saha, K. (2020). Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies. Stem Cell Research & Therapy, 11(1), 234. https://doi.org/10.1186/s13287-020-01741-4

Udry F, Decembrini S, Gamm DM, Déglon N, Kostic C, Arsenijevic Y. (2020). Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level. Science Reports, 10(1):8890. doi: 10.1038/s41598-020-65657-y. PMID: 32483256; PMCID: PMC7264209.

Molugu, K., Harkness, T., Carlson-Stevermer, J., Prestil, R., Piscopo, N. J., Seymour, S. K., Knight, G. T., Ashton, R. S., & Saha, K. (2020). Tracking and Predicting Human Somatic Cell Reprogramming Using Nuclear Characteristics. Biophysical journal, 118(9), 2086–2102. https://doi.org/10.1016/j.bpj.2019.10.014

Morrow, C. S., Porter, T. J., Xu, N., Arndt, Z. P., Ako-Asare, K., Heo, H. J., Thompson, E. A. N., & Moore, D. L. (2020). Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit. Cell stem cell, 26(4), 558–568.e9. https://doi.org/10.1016/j.stem.2020.01.018

Li M, Shin J, Risgaard RD, Parries MJ, Wang J, Chasman D, Liu S, Roy S, Bhattacharyya A, Zhao X. (2020). Identification of FMR1-regulated molecular networks in human neurodevelopment. Genome Research, 30(3):361-374. doi: 10.1101/gr.251405.119. Epub 2020 Mar 16. PMID: 32179589; PMCID: PMC7111522.

Bhattacharyya A. (2020). Advancing Knowledge of Down Syndrome Brain Development and Function With Human Stem Cells. American Journal of Intellectual and Developmental Disabilities, 125(2):90-92. doi: 10.1352/1944-7558-125.2.90. PMID: 32058817; PMCID: PMC7169307.

Jiwlawat N, Lynch EM, Napiwocki BN, Stempien A, Ashton RS, Kamp TJ, Crone WC, Suzuki M. (2019). Micropatterned substrates with physiological stiffness promote cell maturation and Pompe disease phenotype in human induced pluripotent stem cell-derived skeletal myocytes. Biotechnology and Bioengineering, 116(9):2377-2392. doi: 10.1002/bit.27075.

Chasman D, Iyer N, Fotuhi Siahpirani A, Estevez Silva M, Lippmann E, McIntosh B, Probasco MD, Jiang P, Stewart R, Thomson JA, Ashton RS, Roy S. (2019). Inferring Regulatory Programs Governing Region Specificity of Neuroepithelial Stem Cells during Early Hindbrain and Spinal Cord Development. Cell Systems, 28;9(2):167-186.e12. doi: 10.1016/j.cels.2019.05.012.

Bradley RA, Shireman J, McFalls C, Choi J, Canfield SG, Dong Y, Liu K, Lisota B, Jones JR, Petersen A, Bhattacharyya A, Palecek SP, Shusta EV, Kendziorski C, Zhang SC. (2019). Regionally specified human pluripotent stem cell-derived astrocytes exhibit different molecular signatures and functional properties. Development, 8;146(13):dev170910. doi: 10.1242/dev.170910.

Li, M., Hunt, J., Bhattacharyya, A., & Zhao, X. (2019). One-Step Generation of Seamless Luciferase Gene Knockin Using CRISPR/Cas9 Genome Editing in Human Pluripotent Stem Cells. Methods in molecular biology (Clifton, N.J.), 1942, 61–69. https://doi.org/10.1007/978-1-4939-9080-1_5

Hunt, J., Li, M., Zhao, X., & Bhattacharyya, A. (2019). Using Human Neural Progenitor Cell Models to Conduct Large-Scale Drug Screens for Neurological and Psychiatric Diseases. Methods in molecular biology (Clifton, N.J.), 1942, 79–88. https://doi.org/10.1007/978-1-4939-9080-1_7

Morrow, C. S., & Moore, D. L. (2019). Stem Cell Aging? Blame It on the Niche. Cell stem cell, 24(3), 353–354. https://doi.org/10.1016/j.stem.2019.02.011

Shahi PK, Hermans D, Sinha D, Brar S, Moulton H, Stulo S, Borys KD, Capowski E, Pillers DM, Gamm DM, Pattnaik BR. (2019). Gene Augmentation and Readthrough Rescue Channelopathy in an iPSC-RPE Model of Congenital Blindness. American Journal of Human Genetics, 104(2):310-318. doi: 10.1016/j.ajhg.2018.12.019.

Yin, Y., Petersen, A. J., Soref, C., Richards, W. D., Ludwig, T., Taapken, S., Berndt, E., Zhang, S. C., & Bhattacharyya, A. (2019). Generation of seven induced pluripotent stem cell lines from neonates of different ethnic backgrounds. Stem cell research, 34, 101365. https://doi.org/10.1016/j.scr.2018.101365

Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. (2019). CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nature Communications, 3;10(1):53. doi: 10.1038/s41467-018-07971-8.

Moon HY, Javadi S, Stremlau M, Yoon KJ, Becker B, Kang SU, Zhao X, van Praag H. (2019). Conditioned media from AICAR-treated skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells. Neuropharmacology, 145(Pt A):123-130. doi: 10.1016/j.neuropharm.2018.10.041.

Capowski EE, Samimi K, Mayerl SJ, Phillips MJ, Pinilla I, Howden SE, Saha J, Jansen AD, Edwards KL, Jager LD, Barlow K, Valiauga R, Erlichman Z, Hagstrom A, Sinha D, Sluch VM, Chamling X, Zack DJ, Skala MC, Gamm DM. (2019). Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines. Development, 146(1). pii: dev171686. doi: 10.1242/dev.171686.

Upadhya D, Hattiangady B, Castro OW, Shuai B, Kodali M, Attaluri S, Bates A, Dong Y, Zhang SC, Prockop DJ, Shetty AK. (2019). Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration. PNAS USA, 116(1):287-296. doi: 10.1073/pnas.1814185115.

Zhao X, Bhattacharyya A. (2018). Human Models Are Needed for Studying Human Neurodevelopmental Disorders. American Journal of Human Genetics, 103(6):829-857. doi: 10.1016/j.ajhg.2018.10.009. Review.

Ludwig TE, Kujak A, Rauti A, Andrzejewski S, Langbehn S, Mayfield J, Fuller J, Yashiro Y, Hara Y, Bhattacharyya A. (2018). 20 Years of Human Pluripotent Stem Cell Research: It All Started with Five Lines. Cell Stem Cell, 23(5):644-648. doi: 10.1016/j.stem.2018.10.009.

Knight GT, Lundin BF, Iyer N, Ashton LM, Sethares WA, Willett RM, Ashton RS. (2018). Engineering induction of singular neural rosette emergence within hPSC-derived tissues. Elife, 29;7. pii: e37549. doi: 10.7554/eLife.37549.

Galloway CA, Dalvi S, Shadforth AMA, Suzuki S, Wilson M, Kuai D, Hashim A, MacDonald LA, Gamm DM, Harkin DG, Singh R. (2018). Characterization of Human iPSC-RPE on a Prosthetic Bruch’s Membrane Manufactured From Silk Fibroin. Investigative Ophthalmology & Visual Science, 1;59(7):2792-2800.

Lakowski J, Welby E, Budinger D, Di Marco F, Di Foggia V, Bainbridge JWB, Wallace K, Gamm DM, Ali RR, Sowden JC. (2018). Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell-Derived Retinal Organoids and Fetal Retinae. Stem Cells, 36(5):709-722. doi: 10.1002/stem.2775.

Langer KB, Ohlemacher SK, Phillips MJ, Fligor CM, Jiang P, Gamm DM, Meyer JS. (2018). Retinal Ganglion Cell Diversity and Subtype Specification from Human Pluripotent Stem Cells. Stem Cell Reports, 10(4):1282-1293. doi: 10.1016/j.stemcr.2018.02.010.

Estevez-Silva MC, Sreeram A, Cuskey S, Fedorchak N, Iyer N, Ashton RS. (2018). Single-injection ex ovo transplantation method for broad spinal cord engraftment of human pluripotent stem cell-derived motor neurons. Journal of Neuroscience Methods, 15;298:16-23. doi: 10.1016/j.jneumeth.2018.01.006.

Phillips MJ, Jiang P, Howden S, Barney P, Min J, York NW, Chu LF, Capowski EE, Cash A, Jain S, Barlow K, Tabassum T, Stewart R, Pattnaik BR, Thomson JA, Gamm DM. (2018). A Novel Approach to Single Cell RNA-Sequence Analysis Facilitates In Silico Gene Reporting of Human Pluripotent Stem Cell-Derived Retinal Cell Types. Stem Cells. 36(3):313-324. doi: 10.1002/stem.2755.

Phillips MJ, Capowski EE, Petersen A, Jansen AD, Barlow K, Edwards KL, Gamm DM. (2018). Generation of a rod-specific NRL reporter line in human pluripotent stem cells. Scientific Reports, 8(1):2370. doi: 10.1038/s41598-018-20813-3.

Steyer B, Bu Q, Cory E, Jiang K, Duong S, Sinha D, Steltzer S, Gamm D, Chang Q, Saha K. (2018). Scarless Genome Editing of Human Pluripotent Stem Cells via Transient Puromycin Selection. Stem Cell Reports, 13;10(2):642-654. doi: 10.1016/j.stemcr.2017.12.004.

Zhao X, Moore DL. (2018). Neural stem cells: developmental mechanisms and disease modeling. Cell and Tissue Research. 371(1):1-6. doi: 10.1007/s00441-017-2738-1.

Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen Š, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J. (2017). PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer’s Disease. Stem Cell Reports, 9(6):1885-1897. doi: 10.1016/j.stemcr.2017.10.016.

Lemke KA, Aghayee A, Ashton RS. (2017). Deriving, regenerating, and engineering CNS tissues using human pluripotent stem cells. Current Opinions in Biotechnology, 47:36-42. doi: 10.1016/j.copbio.2017.05.010.

Galloway CA, Dalvi S, Hung SSC, MacDonald LA, Latchney LR, Wong RCB, Guymer RH, Mackey DA, Williams DS, Chung MM, Gamm DM, Pébay A, Hewitt AW, Singh R. (2017). Drusen in patient-derived hiPSC-RPE models of macular dystrophies. Proceedings of the National Academy of Sciences of the United States, 26;114(39):E8214-E8223. doi: 10.1073/pnas.1710430114.

Gao Y, Wang F, Eisinger BE, Kelnhofer LE, Jobe EM, Zhao X. (2017). Integrative Single-Cell Transcriptomics Reveals Molecular Networks Defining Neuronal Maturation During Postnatal Neurogenesis. Cerebral Cortex, 27(3):2064-2077. doi: 10.1093/cercor/bhw040.

Jobe EM, Gao Y, Eisinger BE, Mladucky JK, Giuliani CC, Kelnhofer LE, Zhao X. (2017). Methyl-CpG-Binding Protein MBD1 Regulates Neuronal Lineage Commitment through Maintaining Adult Neural Stem Cell Identity. Journal of Neuroscience. 37(3):523-536. doi: 10.1523/JNEUROSCI.1075-16.2016.

Lavine JA, Farnoodian M, Wang S, Darjatmoko SR, Wright LS, Gamm DM, Ip MS, Sorenson CM, Sheibani N. (2017). β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Investigative Ophthalmology and Visual Science, 58(1):299-308. doi: 10.1167/iovs.16-20204.

Tao Y, Zhang SC. (2016) Neural Subtype Specification from Human Pluripotent Stem Cells. Cell Stem Cell. 19(5):573-586. doi: 10.1016/j.stem.2016.10.015.

Zhong X, Hao L, Lu J, Ye H, Zhang SC, Li L. (2016) Quantitative analysis of serotonin secreted by human embryonic stem cells-derived serotonergic neurons via pH-mediated online stacking-CE-ESI-MRM. Electrophoresis. 37(7-8):1027-30. doi: 10.1002/elps.201500496.

Lu J, Zhong X, Liu H, Hao L, Huang CT, Sherafat MA, Jones J, Ayala M, Li L, Zhang SC. (2016) Generation of serotonin neurons from human pluripotent stem cells. Nature Biotechnology. 34(1):89-94. doi: 10.1038/nbt.3435.

Capowski EE, Wright LS, Phillips MJ, Wallace K, Petelinsek A, Hagstrom A, Pinilla I, Borys K, Lien J, Min JH, Keles S, Thomson JA, Gamm DM, Liang K. (2016) Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells. Stem Cells, 34(11):2625-2634. doi: 10.1002/stem.2414.

Onorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell’Anno MT, Gulden FO, Pochareddy S, Tebbenkamp ATN, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N. (2016). Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell Reports, 16(10):2576-2592. doi: 10.1016/j.celrep.2016.08.038. Epub 2016 Aug 24. PMID: 27568284

Damnernsawad A, Kong G, Wen Z, Liu Y, Rajagopalan A, You X, Wang J, Zhou Y, Ranheim EA, Luo HR, Chang Q, Zhang J. (2016) Kras is Required for Adult Hematopoiesis. Stem Cells. 34(7):1859-71. doi: 10.1002/stem.2355.

Kong G, Chang YI, Damnernsawad A, You X, Du J, Ranheim EA, Lee W, Ryu MJ, Zhou Y, Xing Y, Chang Q, Burd CE, Zhang J. (2016) Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis. Leukemia, 30(7):1542-51. doi: 10.1038/leu.2016.40.

Leach LL, Croze RH, Hu Q, Nadar VP, Clevenger TN, Pennington BO, Gamm DM, Clegg DO. (2016) Induced Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium: A Comparative Study Between Cell Lines and Differentiation Methods. Journal of Ocular Pharmacology and Therapeutics. 32(5):317-30. doi: 10.1089/jop.2016.0022.

Bhattacharyya A, Zhao X. (2016) Human pluripotent stem cell models of Fragile X syndrome. Molecular and Cellular Neurosciences. 73:43-51. PubMed PMID: 26640241; PubMed Central PMCID: PMC4867245.

Steyer B, Carlson-Stevermer J, Angenent-Mari N, Khalil A, Harkness T, Saha K. (2016) High content analysis platform for optimization of lipid mediated CRISPR-Cas9 delivery strategies in human cells. Acta Biomaterialia, 34:143-158. doi: 10.1016/j.actbio.2015.12.036.

Wang F, Tidei JJ, Polich ED, Gao Y, Zhao H, Perrone-Bizzozero NI, Guo W, Zhao X. (2015) Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis. Proceedings of the National Academy of Sciences USA, 112(36):E4995-5004. doi: 10.1073/pnas.1513780112.

Chow CL, Guo W, Trivedi P, Zhao X, Gubbels SP. (2015) Characterization of a unique cell population marked by transgene expression in the adult cochlea of nestin-CreER T2 /tdTomato-reporter mice. Journal of Comparative Neurology, 523(10):1474-87. doi: 10.1002/cne.23747.

Guo W, Polich ED, Su J, Gao Y, Christopher DM, Allan AM, Wang M, Wang F, Wang G, Zhao X. (2015) Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms. Cell Reports, 11(10):1651-66. doi: 10.1016/j.celrep.2015.05.013.

Du ZW, Chen H, Liu H, Lu J, Qian K, Huang CL, Zhong X, Fan F, Zhang SC. (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nature Communications, 6:6626. doi: 10.1038/ncomms7626.

Bernau K, Lewis CM, Petelinsek AM, Benink HA, Zimprich CA, Meyerand ME, Suzuki M, Svendsen CN. (2014) In vivo tracking of human neural progenitor cells in the rat brain using bioluminescence imaging. Journal of Neuroscience Methods. 15;228:67-78. doi: 10.1016/j.jneumeth.2014.03.005.

Costanzo ES, Juckett MB, Coe CL. (2013) Biobehavioral influences on recovery following hematopoietic stem cell transplantation. Brain, Behavior and Immunity. 30 Suppl:S68-74.

Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M, Zhang SC. (2013) Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nature Biotechnology. 31(5):440-7.

McMillan EL, Kamps AL, Lake SS, Svendsen CN, Bhattacharyya A. (2012) Gene expression changes in the MAPK pathway in both Fragile X and Down syndrome human neural progenitor cells. American Journal of Stem Cells. 30;1(2):154-162.

Luo Y, Shan G, Guo W, Smrt RD, Johnson EB, Li X, Pfeiffer RL, Szulwach KE, Duan R, Barkho BZ, Li W, Liu C, Jin P, Zhao X. (2010) Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genetics. Apr 8;6(4):e1000898.

Cairney CJ, Sanguinetti G, Ranghini E, Chantry AD, Nostro MC, Bhattacharyya A, Svendsen CN, Keith WN, Bellantuono I. (2009) A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging. Biochim Biophys Acta. 1792(4):353-63.

Bhattacharyya A, McMillan E, Chen SI, Wallace K, Svendsen CN. (2009) A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells. Developmental Neuroscience. 31(6):497-510 .

Bhattacharyya A, McMillan E, Wallace K, Tubon TC Jr, Capowski EE, Svendsen CN. (2008) Normal neurogenesis but abnormal gene expression in human fragile x cortical progenitor cells. Stem Cells and Development. 17(1):107-17.