Seminar – Oleksandr Shcheglovitov, PhD – “Single Rosette Organoids as a Model of Development and Disease”

Oleksandr Shcheglovitov, PhD University of Utah Profile About the Speaker: Oleksandr “Alex” Shcheglovitov, PhD is an Associate Professor of Neurobiology from the University of Utah. He obtained his Ph.D. in biophysics from the Bogomolets Institute of Physiology. He did his postdoctoral training with Dr. Ed Perez-Reyes at the University of Virginia and Dr. Ricardo Dolmetsch at Stanford University. His lab’s research is focused on understanding the cellular and molecular mechanisms of human cortical development under both normal and pathological conditions. To do this, they use a combination of patient-derived and CRISPR-engineered induced pluripotent stem cells (iPSCs). They produce iPSCs from easily accessible cells, such as blood or skin, that are acquired from both healthy control individuals and patients with genetic disorders. They then differentiate iPSCs into cortical neurons or three-dimensional human brain structures called ‘organoids’ in order to probe genetic abnormalities and the underlying molecular mechanisms. [uw-reusable-content id=’27295′]