Pelin Cengiz, MD
Associate Professor, Pediatrics
MD, Marmara University School of Medicine, Istanbul
Associate Professor, Department of Pediatrics
T515, Waisman Center
1500 Highland Ave
Madison, WI 53705
Dr. Pelin Cengiz’s research focuses on finding a novel therapy for neonatal encephalopathy subsequent to hypoxia ischemia (HI). She uses the experimental (Vannucci-Rice) mouse model of hypoxia ischemia (HI) to study the sexually differentiated role of neurotrophin signaling in the neonatal hippocampus post-HI. The neurotrophin receptor, tyrosine kinase B (TrkB), plays an important role in neuroprotection and improving the long-term functional recovery following cerebral ischemia by increasing neuronal survival. She has shown that administration of 7,8 dihydroxyflavone (7,8-DHF; potent and selective TrkB agonist) increases TrkB phosphorylation and hippocampal neuronal survival following HI in female, but not in male newborn mice. This female-specific responsiveness to TrkB agonist therapy mimics improved outcomes observed clinically in female newborn humans post-HI. Her studies focus on the cellular mechanisms of the female-specific responsiveness to TrkB agonist and their roles in improving long-term neurological and functional outcome post-HI. An improved understanding of the cellular mechanisms that underlie sex-specific neurotrophin responses will identify new avenues for developing novel therapeutics for neonates and children suffering from brain injury.
As a University of Wisconsin former ICTR KL2 scholar, the Clinical and Translational Research Training she obtained benefitted her tremendously. http://www.med.wisc.edu/quarterly/clinical-and-translational-research-training-benefits-physicians-and-patients/45491
Dr. Cengiz’s clinical duties include serving as an Attending in the PICU and in the Outpatient Sedation Clinic at American Family Children’s Hospital. Abroad, she is an active member of the international health community.
Additional Research Activities
- Role of estrogen receptors and TrkB signaling in sexed hippocampal astrocytes and neurons after in-vitro ischemia
- TrkB signaling in sex specific hypothermic neuroprotection
- Sex specific protective effects of 7,8 DHF on learning and memory after HI
- TrkB signaling and hypoxia-ischemia induced retinopathy
Chandran R, Kim T, Mehta SL, Udho E, Chanana V, Cengiz P, Kim H, Kim C, Vemuganti R. (2017). A combination antioxidant therapy to inhibit NOX2 and activate Nrf2 decreases secondary brain damage and improves functional recovery after traumatic brain injury. Journal of Cerebral Blood Flow & Metabolism. In Press
Cikla U, Chanana V, Kintner DB, Covert L, Dewall T, Waldman A, Rowley P, Cengiz P, Ferrazzano P. (2016) Suppression of microglia activation after hypoxia-ischemia results in age-dependent improvements in neurologic injury. Journal of Neuroimmunology. 15;291:18-27. doi: 10.1016/j.jneuroim.2015.12.004.
Chanana V, Tumturk A, Kintner D, Udho E, Ferrazzano P, Cengiz P. (2016) Sex Differences in Mouse Hippocampal Astrocytes after In-Vitro Ischemia. Journal of Visualized Experiments. 25;(116). doi: 10.3791/53695.
Cikla U, Chanana V, Kintner DB, Udho E, Eickhoff J, Sun W, Marquez S, Covert L, Otles A, Shapiro RA, Ferrazzano P, Vemuganti R, Levine JE, Cengiz P. (2016) ERα Signaling Is Required for TrkB-Mediated Hippocampal Neuroprotection in Female Neonatal Mice after Hypoxic Ischemic Encephalopathy (1,2,3). eNeuro. 28;3(1). pii: ENEURO.0025-15.2015. doi: 10.1523/ENEURO.0025-15.2015.
Cengiz P, Zemlan F, Eickhoff JC, Ellenbogen R, Zimmerman JJ. (2015) Increased cerebrospinal fluid cleaved tau protein (C-tau) levels suggest axonal damage in pediatric patients with brain tumors. Child’s Nervous System. In Press.
Li S, Papale LA, Kintner DB, Sabat G, Barrett-Wilt GA, Cengiz P, Alisch RS. (2015) Hippocampal increase of 5-hmC in the glucocorticoid receptor gene following acute stress. Behavioral Brain Research. 1;286:236-40. doi: 10.1016/j.bbr.2015.03.002.
Cengiz P, Kintner DB, Chanana V, Yuan H, Akture E, Kendigelen P, Begum G, Fidan E, Uluc K, Ferrazzano P, Sun D. (2014) Sustained Na+/H+ exchanger activation promotes gliotransmitter release from reactive hippocampal astrocytes following oxygen-glucose deprivation. PLoS One. 2;9(1):e84294.
Uluc K, Kendigelen P, Fidan E, Zhang L, Chanana V, Kintner D, Akture E, Song C, Ye K, Sun D, Ferrazzano P, Cengiz P. (2013) TrkB Receptor Agonist 7, 8 Dihydroxyflavone Triggers Profound Gender- Dependent Neuroprotection in Mice After Perinatal Hypoxia and Ischemia. CNS & Neurological Disorders – Drug Targets. 12(3):360-70.
Ferrazzano P, Chanana V, Uluc K, Fidan E, Akture E, Kintner DB, Cengiz P, Sun D. (2013) Age-dependent microglial activation in immature brains after hypoxia- ischemia. CNS & Neurological Disorders – Drug Targets. 12(3):338-49.
Shi Y, Yuan H, Kim D, Chanana V, Baba A, Matsuda T, Cengiz P, Ferrazzano P, Sun D. (2013) Stimulation of Na(+)/H(+) exchanger isoform 1 promotes microglial migration. PLoS One. 21;8(8):e74201.
Cengiz P, Uluc K, Kendigelen P, Akture E, Hutchinson E, Song C, Zhang L, Lee J, Budoff GE, Meyerand E, Sun D, Ferrazzano P. (2011) Chronic neurological deficits in mice after perinatal hypoxia and ischemia correlate with hemispheric tissue loss and white matter injury detected by MRI. Developmental Neuroscience. 33(3-4):270-9.
Cengiz P, Kleman N, Uluc K, Kendigelen P, Hagemann T, Akture E, Messing A, Ferrazzano P, Sun D. (2011) Inhibition of Na+/H+ exchanger isoform 1 is neuroprotective in neonatal hypoxic ischemic brain injury. Antioxidants & Redox Signaling. 14(10):1803-13.
Liu Y, Kintner DB, Begum G, Algharabli J, Cengiz P, Shull GE, Liu XJ, Sun D. (2010) Endoplasmic reticulum Ca2+ signaling and mitochondrial Cyt c release in astrocytes following oxygen and glucose deprivation. Journal of Neurochemistry. 1;114(5):1436-46.
Cengiz P, Zemlan F, Ellenbogen R, Hawkins D, Zimmerman JJ. (2008) Cerebrospinal fluid cleaved-tau protein and 9-hydroxyoctadecadienoic acid concentrations in pediatric patients with hydrocephalus. Pediatric Critical Care Medicine. 9(5):524-9. doi: 10.1097/PCC.0b013e3181849dc9.
Cengiz P, Seidel K, Rycus PT, Brogan TV, Roberts JS. (2005) Central nervous system complications during pediatric extracorporeal life support: incidence and risk factors. Critical Care Medicine. 33(12):2817-24.
Cengiz P, Zimmerman JJ. (2003) Prelude to pediatric multiple organ dysfunction syndrome: the golden hours concept revisited. Pediatric Critical Care Medicine. 4(2):263-4.
Cengiz P, Zimmerman JJ. (2001) Putting together the pieces. Critical Care Medicine. 29(12):2390-1.