University of Wisconsin–Madison

2018 Waisman Center Calendar – March

Fluorescence microscopy image of a nerve cell derived from induced pluripotent stem cells donated by an individual with Rett syndrome.
Fluorescence microscopy image of a nerve cell derived from induced pluripotent stem cells donated by an individual with Rett syndrome. Chang uses these cells to develop and test potential treatments and therapies. (Image provided by the Chang lab)

Searching for understanding, and a cure: Rett syndrome is a rare non-inherited neurological disorder that mostly affects girls and causes severe deterioration in their ability to speak, walk, eat and even breathe easily. This disease is caused by variations in a gene called MECP2. Waisman Center investigator Qiang Chang uses human stem cell and animal models to better understand how variations in MECP2 cause Rett syndrome. Understanding these fundamental biological mechanisms will help researchers, like Chang, develop new and effective treatments and therapies for the disease. To learn more about Chang’s research, please click here.