Individuals with cerebellar ataxia (CA) caused by cerebellar degeneration exhibit larger reactive compensatory responses to unexpected auditory feedback perturbations than neurobiologically typical speakers, suggesting they may rely more on feedback control during speech. We test this hypothesis by examining variability in unaltered speech. Previous studies of typical speakers have demonstrated a reduction in formant variability (centering) observed during the initial phase of vowel production from vowel onset to vowel midpoint.
Month: February 2021
Peter Ferrazzano, MD – Slide of the Week
Adolescent traumatic brain injury (TBI) is a major public health concern, resulting in over 35,000 hospitalizations in the U.S. each year. While neuroimaging is a primary diagnostic tool in the clinical assessment of TBI, our understanding of how specific neuroimaging findings relate to outcome remains limited. Our study aims to identify imaging biomarkers of long-term neurocognitive outcome after severe adolescent TBI.
Caroline A Niziolek, PhD – Slide of the Week
Speakers use auditory feedback to guide their speech output, although individuals differ in the magnitude of their compensatory response to perceived errors in feedback. Little is known about the factors that contribute to the compensatory response or how fixed or flexible they are within an individual. Here, we test whether manipulating the perceived reliability of auditory feedback modulates speakers’ compensation to auditory perturbations, as predicted by optimal models of sensorimotor control.
Thoughts of gratitude: the Willis family
On August 13, 2003, a coach bus pulled up to the Waisman Center. The 21 passengers – all children and grandchildren of the visit’s organizers, Bill and Doris Willis – were coming from Milwaukee to …
Darcie L. Moore, PhD – Slide of the Week
Intermediate filaments are commonly used markers of NSCs in the brain, yet the cell cycle status of a NSC can strongly influence expression of these markers. Thus, intermediate filaments should be used cautiously as markers to study NSCs.