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Neural stem cells (NSCs) must exit quiescence to produce neurons; however, our understanding of this process remains constrained by the technical limitations of current technologies.
Musashi1, a neural RNA binding protein, is important in translationally repressing target transcripts during quiescence in adult hippocampal neural stem cells
Intermediate filaments are commonly used markers of NSCs in the brain, yet the cell cycle status of a NSC can strongly influence expression of these markers. Thus, intermediate filaments should be used cautiously as markers to study NSCs.
New research by University of Wisconsin–Madison scientists reveals how a cellular filament helps neural stem cells clear damaged and clumped proteins, an important step in eventually producing new neurons.
