Neurogenesis is thought to be sustained throughout life through the constant regulation of neural stem cell (NSC) quiescence exit, a time in which a NSC enters the cell cycle to generate more neural stem cells and/or other neural cell types. One critical component of NSC quiescence exit is the clearance of aggregated proteins.
Slide of the Week
Qiang Chang, PhD – Slide of the Week
Rett syndrome (RTT) is a severe neurodevelopmental disease caused by mutations in the methyl-CpG binding protein 2 (MECP2) gene. Although altered interneuron development and function are clearly demonstrated in RTT mice, a particular mode of inhibition, tonic inhibition, has not been carefully examined.
Doug Dean, III, PhD – Slide of the Week
Title: Mapping white matter microstructure in the one month human brain Legend: Infants underwent magnetic resonance imaging (MRI) at 1-month of age and measures of white matter microstructure were calculated using diffusion tensor imaging (DTI) and …
Karla Ausderau, PhD – Slide of the Week
Mealtime is an important family routine commonly affected for families with children with autism spectrum disorders (ASD). Limited research is available regarding strategies families incorporate to support mealtime engagement. The purpose of this study was to explore the frequency and characterize the purpose of Props used during mealtimes with children with ASD.
Richard J Davidson, PhD – Slide of the Week
Reduced hippocampal volume is frequently observed in posttraumatic stress disorder (PTSD), but the psychological processes associated with these alterations remain unclear. Given hippocampal involvement in memory and contextual representations of threat, we investigated relationships between retrospectively reported combat exposure, perceived threat, and hippocampal volume in trauma-exposed veterans.
Christopher L. Coe, PhD – Slide of the Week
Title: Maternal perceived stress during pregnancy increases risk for low neonatal iron at delivery and depletion of storage iron at one year of age. Citation: Rendina D, Blohowiak S, Coe C, Kling P. Maternal perceived …
Lauren Bishop, PhD – Slide of the Week
We have seen a profound increase in lifespan for individuals with Down syndrome (DS) in the past few decades leading to a large and somewhat understudied population of middle- and older aged adults with DS. One health condition consistently seen in clinic-based DS samples is dementia (including Alzheimer’s disease).
Bradley T Christian, PhD – Slide of the Week
Title: Amyloid load in the Down syndrome population measured with [11C]PiB PET Legend: Down syndrome-specific [11C]PiB PET template images of Aβ carrying capacity and radiotracer nonspecific binding derived from PET images of 169 individuals. Tissue maps …
Sriram Boothalingam, PhD – Slide of the Week
The auditory brainstem reflex tag-team: panel A is a schematic of the neural connections between two brainstem auditory reflexes, the medial olivocochlear (MOCR) and the middle ear muscle (MEMR) reflex. While we know that the two reflexes work in tandem and at slightly different frequencies and input sound levels, how the activity of one reflex influences the other is poorly understood.
Anita Bhattacharyya, PhD – Slide of the Week
To identify mechanisms that lead to neurodevelopmental differences in Down syndrome, we used induced pluripotent stem cells (iPSCs) generated from individuals with Down syndrome and differentiated them into progenitors of the cerebral cortex. The progenitors were analyzed by RNA Seq at Day 17 in culture when cells have acquired their positional phenotype.