Christopher Coe, PhD – Slide of the Week

Birth weight (BW) at delivery is an important developmental milestone indicative of prenatal conditions and portends of the postnatal growth trajectory that will occur during infancy and childhood. Previous research has documented that there are also many physiological and health consequences of being born either small-for-gestational age (SGA) or large-for-gestational age (LGA).

Bradley T Christian, PhD – Slide of the Week

Adults with Down syndrome (DS) are predisposed to Alzheimer’s disease (AD) and a characterization of glucose metabolism change throughout AD progression has yet to be performed in this population. Using FDG PET, regional glucose metabolism was evaluated across groups of cognitively stable DS (CS-DS), DS with mild cognitive impairment or Alzheimer’s disease (MCI-DS/AD), and healthy non-DS sibling controls.

Qiang Chang, PhD – Slide of the Week

Rett syndrome (RTT) is a severe X chromosome-linked debilitating neurodevelopmental disorder caused by mutations in the MECP2 gene affects 1 in 10,000-15,000 girls with no effective treatment. Our lab has been using RTT induced pluripotent stem cells (iPSC) and neurons and astrocytes differentiated from iPSC as a platform to understand RTT disease mechanisms and develop treatment.

Sriram Boothalingam, PhD – Slide of the Week

This study describes a time series-based method of middle ear muscle reflex (MEMR) detection using bilateral clicks, with implications for otoacoustic emission (OAE)-based medial olivocochlear reflex (MOCR) assays. Although current click-based methods can detect changes in the OAE evoking stimulus to monitor the MEMR, these methods do not discriminate between true MEMR-mediated vs. artifactual changes in the stimulus.

Lauren Bishop, PhD – Slide of the Week

Although epilepsy commonly presents with autism in children, it is currently unknown whether established estimates represent the prevalence and incidence of epilepsy in autistic adults. Our objective was to use population-level Medicaid data to determine prevalence, incidence, and antiepileptic drug use associated with epilepsy in a unique population of autistic adults aged 21+ with (N=2,738) and without (N=4,775) intellectual disability and to compare results to adults with intellectual disability alone (N=18,429).

Barbara Bendlin, PhD – Slide of the Week

In Alzheimer’s disease (AD), neurodegenerative processes are ongoing for years prior to the time that cortical atrophy can be reliably detected using conventional neuroimaging techniques. Recent advances in diffusion-weighted imaging have provided new techniques to study neural microstructure, which may provide additional information regarding neurodegeneration.

Karla Ausderau, PhD – Slide of the Week

Examine healthcare usage, pharmacy prescriptions and healthcare cost among people with Intellectual Disability in Wisconsin who participate in Special Olympics compared to people with Intellectual Disability who do not participate in Special Olympics. In addition, a sub-analysis was completed to compare Special Olympics athletes who participated in the Healthy Athlete program to those who had not.

UCEDD – Slide of the Week

Title: Pre- to post-training change in childcare provider belief that developmental monitoring is important and ability to identify appropriate referrals to make when there is a developmental concern Legend: Training in developmental monitoring significantly increases …

Andrew Alexander, PhD – Slide of the Week

Demonstration of the ability of MPnRAGE to correct for severe motion artifacts in a 7 year old girl.  Retrospective motion correction greatly reduced motion-induced blurring in both  structural T1-weighted images and quantitative T1 maps.  The correction greatly improves the reliability of brain imaging measurements in children.  The plots indicate the estimated amount of head motions that were corrected.