Leber Congenital Amaurosis (LCA16) is a progressive vision loss disorder caused by point mutations in the KCNJ13 gene, which encodes an inward-rectifying potassium channel, Kir7.1.
Slide of the Week
Jenny Saffran, PhD – Slide of the Week
Online data collection methods pose unique challenges and opportunities for infant researchers.
Luigi Puglielli, MD, PhD – Slide of the Week
N ε-lysine acetylation within the lumen of the endoplasmic reticulum is a recently characterized protein quality control system that positively selects properly folded glycoproteins in the early secretory pathway.
Robert A. Pearce, MD, PhD – Slide of the Week
We recently reported that the competitive NMDAR antagonist (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) does not suppress NMDAR-mediated field EPSPs (fEPSPNMDA) or long-term potentiation (LTP) in vitro at concentrations that block contextual conditioning in vivo. Here we tested one possible explanation for the mismatch – that the hippocampus is relatively resistant to CPP compared to other brain structures engaged in contextual fear conditioning.
Ben Parrell, PhD – Slide of the Week
Sensory errors induce two types of behavioral changes: rapid compensation within a movement and longer-term adaptation of subsequent movements.
Carrie Niziolek, PhD – Slide of the Week
Although movement variability is often attributed to unwanted noise in the motor system, recent work has demonstrated that variability may be actively controlled.
Darcie L. Moore, PhD – Slide of the Week
Neural stem cells (NSCs) in the adult brain are primarily quiescent. When they receive signals, they can activate, re-entering into the cell cycle. Technologies capable of detecting a quiescent from an activated NSC in live cells are limited.
Marsha R. Mailick, PhD – Slide of the Week
FXTAS is characterized by intention tremor, gait ataxia, executive function deficits, memory issues, and neuropathy.
James J. Li, PhD – Slide of the Week
Parenting behavior is a well-established correlate of offspring ADHD. However, little is known about how parenting exerts its effects on offspring ADHD symptomatology.
Margarita Kaushanskaya, PhD – Slide of the Week
Code-switching occurs regularly in the input to bilingual children. Yet, the effect of code-switched input on language development is unclear.