Title: Assessing hPSC-OV (Human Pluripotent Stem Cell-Optical Vesicle) Production and PR Maturation with a CRX Reporter Line. Legend: A) Consecutive live images showing increased tdTomato fluorescence from one CRX+/tdTomato OV from day 28 to day 60 …
Immunostaining and microglia isolation via magnetic cell sorting was performed at postnatal day 2, 9, 30 and 60 (P2, P9, P30, P60). Microglia branching and soma size were quantified using semiautomated software analysis (Imaris, Oxford Insturments).
Human pluripotent stem cell-derived neural organoids provide unprecedented potential to recapitulate human brain and spinal cord tissues in vitro. However, organoid morphogenesis relies upon cell-intrinsic self-assembly of biomimetic tissue structures in the absence of normal developmental constraints and morphogen signaling centers.
Objectives: To describe the association between indicators of SES and the prevalence of ASD in the United States during the period 2002 to 2010, when overall ASD prevalence among children more than doubled, and to determine whether SES disparities account for ongoing racial and ethnic disparities in ASD prevalence.
Weak central coherence (processing details over gist), poor oral language abilities, poor suppression, semantic interference, and poor comprehension monitoring have all been implicated to affect reading comprehension in individuals with ASD.
Currently there are few evidence-based programs available for families of individuals with ASD during the transition to adulthood. The present study provided a preliminary evaluation of a multi-family group psychoeducation intervention using a randomized waitlist control design (n = 41).
Empathy, the ability to understand others’ emotions, can occur through perspective taking and experience sharing. Neural systems active when adults empathize include regions underlying perspective taking (e.g. medial prefrontal cortex; MPFC), and experience sharing (e.g. inferior parietal lobule; IPL).
Hormones present in hair provide summative information about endocrine activity while the hair was growing. Therefore, it can be collected from an infant after birth and still provide retrospective information about hormone exposure during prenatal development.
Alzheimer’s disease is characterized by accumulation of beta amyloid (Aβ) and hyperphosphorylated tau proteins, which neuropathology suggests follow distinct spatiotemporal patterns.
Rett syndrome (RTT) is a debilitating neurodevelopmental disorder caused by mutations in the MECP2 gene. To