Title: Role of tau deposition in early cognitive decline in Down syndrome
Legend: Boxplots depicting median and variation for episodic memory score by PET amyloid beta (Aβ–vs. Aβ+) and tau (TLvs. TH) status in Braakregions I to VI. Sample includes 123 non-demented adults with DS. Brackets highlight significant (**P< .010) group comparisons in models adjusted for site, premorbid intellectual disability, and chronological age.
Citation: Hartley, S.L., Handen, B.L., Tudorascu, D., Lee, L., Cohen, A., Piro-Gambetti, B., Zammit, M., Klunk, W., Laymon, C., Zaman, S., Ances, B.M., Sabbagh, M., & Christian, B.T. (in press). Role of tau deposition in early cognitive decline in Down syndrome. Alzheimer’s and Dementia: Diagnosis, Assessment & Disease Monitoring. 10.1002/(ISSN)2352-8729.
About the Lab: Sigan Hartley, PhD is an associate professor in the Department of Human Development and Family Studies. Her research examines the individual resources and family contexts underlying positive well-being in individuals with developmental disabilities and their families. Visit the Hartley Lab website.