AT(N) biomarker profiles and Alzheimer’s disease in People with Down syndrome
Sigan Hartley
Neurodegeneration research at the Waisman Center from gene to organelle to cell to brain
Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), Charcot-Marie-Tooth disease, and retinitis pigmentosa all have different manifestations and affect different body functions, but they are all connected by one mechanism: neurodegeneration.
Understanding the connection between Down syndrome and Alzheimer’s disease
Allison and Amber Westemeier get excited every time they take a trip to the Waisman Center from Oshkosh, WI.
The beginnings and evolution of brain imaging at the Waisman Center
The development of brain imaging techniques has helped us understand emotion, intellectual and developmental disabilities, and neurodegenerative diseases in ways we could not before.
Weight loss may be early predictor of Alzheimer’s disease in Down syndrome
Unintentional weight loss in people with Down syndrome may predict the onset of Alzheimer’s disease long before typical cognitive symptoms like memory loss and dementia are apparent.
Waisman postdoctoral training program: Training the next generation of IDD researchers
The first two years of the grant provided funding for two seminars in an academic year, but in a short span, seeing the tangible benefits these had, they expanded from two lectures a year, to two a month.
Thoughts of gratitude: The Dewey family is a catalyst of support for the Waisman Center
Individuals with Down syndrome are at higher risk of developing Alzheimer’s disease, and it typically presents it at an earlier age than the general population. It is estimated that 90% of people with Down syndrome will have developed Alzheimer’s by age 65.
Sigan Hartley, PhD – Slide of the Week
People with Down Syndrome (DS) are at high risk for Alzheimer’s disease (AD) because of their unique biology and provide an unparalleled opportunity to develop biomarkers of preclinical AD.
Postdoctoral program equips a new generation of scientists in IDD research
For more than 26 years, the center’s Postdoctoral Training Program in Intellectual and Developmental Disabilities Research has helped shape the careers and research paths of 53 postdoctoral researchers through multidisciplinary training in social, epidemiological, behavioral and biobehavioral research on intellectual and developmental disabilities (IDD).
Sigan Hartley, PhD – Slide of the Week
Boxplots depicting median and variation for episodic memory score by PET amyloid beta (Aβ–vs. Aβ+) and tau (TLvs. TH) status in Braakregions I to VI.