There is a critical need to identify measures of cognitive functioning sensitive to early Alzheimer’s disease (AD) pathophysiology in Down syndrome to advance clinical trial research in this at-risk population. The objective of the study was to longitudinally track performance on cognitive measures in relation to neocortical and striatal amyloid beta (Aβ) in non-demented Down syndrome.
Sigan Hartley
New NIH-funded initiative will examine Alzheimer’s disease in people with Down syndrome
A team of researchers at the University of Wisconsin–Madison is part of a new multi-institution effort to better understand Alzheimer’s disease in adults with Down syndrome. Adults with Down syndrome are at high risk for …
Sigan Hartley, PhD – Slide of the Week
Family research in the field of ASD has focused on describing the impact of child challenges on parents, usually mothers, and given little attention to the ways in which mothers and fathers reciprocally influence the development of the child with ASD.
Lauren Bishop, PhD – Slide of the Week
We have seen a profound increase in lifespan for individuals with Down syndrome (DS) in the past few decades leading to a large and somewhat understudied population of middle- and older aged adults with DS. One health condition consistently seen in clinic-based DS samples is dementia (including Alzheimer’s disease).
In Wisconsin, 3 in 5 people with Down syndrome diagnosed with dementia by age 55
Not so many years ago, people with Down syndrome rarely survived to middle age. Many died young due to heart problems associated with the congenital condition.
Today, advances in treatment have allowed them to live longer, healthier lives.
Sigan Hartley honored with Romnes Faculty Fellowship
Waisman Center investigator Sigan Hartley, PhD, has been honored with a Romnes Faculty Fellowship. Romnes awards recognize exceptional faculty members who have earned tenure within the last six years. The awards are supported by the …
Sigan Hartley, PhD – Slide of the Week
Parents of children with autism spectrum disorder (ASD) report elevated parenting stress. The current study examined bidirectional effects between parenting stress and three domains of child functioning (ASD symptoms, internalizing behavior problems, and externalizing behavior problems) across four time points in 188 families of children with ASD (originally aged 5 to 12 yrs).
Studying Alzheimer’s disease in individuals with Down syndrome
About once every year and a half, Erin Harvey takes time off of her job as a teacher’s aide and along with her mom, Nancy, makes a two and a half hour drive from her …
Sigan Hartley, PhD – Slide of the Week
We compared the couple conflict of parents of children with autism spectrum disorder (ASD) to a comparison group of parents of children without disabilities using self-reported and observational measures.
Researchers gain insight into day-to-day lives of parents raising children with autism
Like all parents, couples who have a child with autism spectrum disorder (ASD) share the ups and downs of parenting. A new study by Waisman Center researchers at the University of Wisconsin–Madison looks at the …