A new Waisman study found that adverse childhood experiences (ACEs)—such as abuse, neglect, or exposure to household challenges—can have lasting effects on adults with Down syndrome, including their mental health and ability to cope with life changes. While ACES are known to impact the general population, this research is among the first to show similar—and in some cases heightened—effects in individuals with Down syndrome.
Down syndrome
Anita Bhattacharyya, PhD – Slide of the Week
Basal forebrain cholinergic neurons (BFCNs) are integral to learning, attention, and memory, and are prone to degeneration in Down syndrome (DS), Alzheimer’s disease, and other neurodegenerative diseases.
Ruth Litovsky, PhD – Slide of the Week
Individuals with Down syndrome (DS) have a higher incidence of hearing loss (HL) compared with their peers without developmental disabilities.
Sigan Hartley, PhD – Slide of the Week
Mean physical and behavioral depressive symptoms on the Reiss Screen of Maladaptive Behavior (RSMB) across four data collection cycles in sample of 262 adults with Down syndrome. Blue line is for those with low PET amyloid and green line for those with elevated PET amyloid.
NIH establishes $20 million program to study Down syndrome from birth to adulthood
Researchers at the Waisman Center are included in a recently launched a new long-term study to observe and track health data of people with Down syndrome from birth to adulthood
Waisman Center IDDRC funds three pilot projects on novel Down syndrome research
Three Waisman Center investigators and affiliates were awarded an internal grant to support Down syndrome research in its early stages. The funds were made possible through the Ann Dewey Down Syndrome Catalyst Fund at the Waisman Center.
Andrew McVea, MS, (Christian Lab) – Slide of the Week
Earlier beta-amyloid (Aβ) plaque accumulation and a higher prevalence of Alzheimer’s Disease is seen in the Down syndrome (DS) population due to the triplication of chromosome 21 containing the amyloid precursor protein (APP) gene.
Audra Sterling, PhD – Slide of the Week
Dyadic caregiver-child interactions are commonly used to examine children’s language learning environments.
Triple the effort: Clinics, research, and education on Down syndrome at the Waisman Center
Down syndrome is a genetic condition in which all cells in a person’s body have an extra copy of chromosome 21, also known as trisomy 21. Having this extra chromosome affects how an individual’s body …
Earliest effects of chromosome 21 triplication in brain development discovered
It is well established that brain development looks different for individuals with Down syndrome, but how early do these differences appear?