Immunostaining and microglia isolation via magnetic cell sorting was performed at postnatal day 2, 9, 30 and 60 (P2, P9, P30, P60). Microglia branching and soma size were quantified using semiautomated software analysis (Imaris, Oxford Insturments).
Peter Ferrazzano
Treating the trauma of brain injuries
One Wednesday in September, 15-year-old Tristan Thurman went to soccer practice at his high school. The team had just lost a game the day before because the other team had scored goals heading the ball, …
Peter Ferrazzano, MD
Title: Suppression of microglia activation after hypoxia-ischemia results in age-dependent improvements in neurologic injury. Legend: Figure 1. Minocycline treatment suppresses the microglial response to hypoxia-ischemia (HI) in neonatal and juvenile mice. The number of CD11b+/CD45+ …
Tweaking the immune response shows potential for treating brain injuries
Brain injuries caused by a lack of oxygen and blood flow affect many thousands of children every year, yet “we still don’t have effective treatments for them,” says Waisman researcher Peter Ferrazzano, MD.
Peter Ferrazzano, MD
Title: Suppression of microglia activation after hypoxia-ischemia results in age-dependent improvements in neurologic injury. Legend: P9 and P30 mice were exposed to unilateral hypoxia-ischemia and treated with minocycline or vehicle. A, B. Double immunohistological staining …