A new computational pipeline connects disease and discovery at the cellular level

Could Alzheimer’s disease and schizophrenia be biologically connected?  A new computational model, scGRNom (single-cell Gene Regulatory Network prediction from multi- omics), developed by researchers at the University of Wisconsin-Madison, harnesses the power of multi-omics and …

Second seat in Waisman cluster hire filled by neuroscientist André Sousa

Sousa is the second hire in the cluster initiative that includes a biostatistician, a neuroscientist, and a geneticist. The cluster will serve as a nucleus to integrate research, training, and clinical services in the human genomics research area at the Waisman Center. Waisman director Qiang Chang says he is very happy to have Sousa join the Waisman team.

The identities of enzymes: study further defines the function of a potential target for Alzheimer’s therapy

A new study from the lab of UW-Madison professor of medicine Luigi Puglielli, MD, PhD, opens a door to potential treatments for diseases of age, such as Alzheimer’s disease, by defining the roles of two enzymes that are imperative to protein production. “Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism” was published in April in the journal Communications Biology.

Artificial intelligence can accelerate clinical diagnosis of fragile X syndrome

An analysis of electronic health records for 1.7 million Wisconsin patients revealed a variety of health problems newly associated with fragile X syndrome, the most common inherited cause of intellectual disability and autism, and may help identify cases years in advance of the typical clinical diagnosis.

New NIH-funded initiative will examine Alzheimer’s disease in people with Down syndrome

A team of researchers at the University of Wisconsin–Madison is part of a new multi-institution effort to better understand Alzheimer’s disease in adults with Down syndrome. Adults with Down syndrome are at high risk for …