Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
At a Glance: A map of early brain development that captures its major drivers and their dynamics through time has been developed by Waisman Center investigators. Compiling different brain regions across three different species including humans, the new blueprint can identify the upstream regulators of brain development, evolution, and disorder risk, revealing how highly complex …
At a Glance: Developing treatments for rare genetic disorders, such as Rett syndrome, is notoriously difficult, often requiring years of research and significant financial investment. Researchers at the Waisman Center, University of Wisconsin–Madison have developed a new drug screening platform for Rett syndrome that could help accelerate the search for potential therapies while uncovering new …
Identifying the cells connected with Alzheimer’s symptoms could result in new treatments for the disease. By Emily Leclerc and Charlene N. Rivera-Bonet Alzheimer’s disease is complex, presenting and progressing in so many different ways in individual patients that it’s difficult for scientists to study. Now, researchers at the University of Wisconsin–Madison have developed AI-driven bioinformatics …
The study highlights associations between neighborhood disadvantage and an MRI measure of myelin maturation, a marker of brain development, across infancy and childhood.
A new Waisman Center, University of Wisconsin-Madison study has identified a critical regulator of this early process of cell fate called FXR1, a protein that binds RNA to regulate the abundance of key genes.
A newly funded project will combine the expertise of four Waisman Center investigators to develop advanced machine learning methods for studying brain organoids, three-dimensional cell clusters grown from stem cells that closely mimic key aspects of human brain development.
Giang Pham, a rising senior from Lawrence University in Appleton, is spending her second summer doing research at the Waisman Center University of Wisconsin–Madison as part of an internship program established and supported by the late John Mielke, MD, a former member of the Waisman Board of Visitors and Appleton native, and his wife Sally. …
Science is not static. It constantly grows through curiosity, experimentation, and the continuous pursuit of new knowledge. Every question asked, every experiment conducted, and every discovery made build upon what came before it—moving science forward step by step. Students play a critical role in that process. They are not passive learners observing from the sidelines, but active contributors to research.
The electrical properties of a neuron paint a picture of its development and function. A new user-friendly and accessible tool developed at the Waisman Center allows scientists to analyze the electrical activity of individual neurons – rather than clusters – using a process known as spike sorting. The free tool is available online for other researchers to access.
A new research study at the Waisman Center has been funded by the Eagles Autism Foundation to develop a precise, safe, and broadly applicable method for correcting a single-gene mutation associated with symptoms of autism spectrum disorders including learning deficits, anxiety, depression, and reduced social interactions.
