University of Wisconsin–Madison

Tag: PiB PET

Max McLachlan (Christian Lab) Slide of the Week

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Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [11C]Pittsburgh Compound-B (PiB) positron emission tomography (PET) imaging, which has not been replicated with [18F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures.

Andrew McVea, MS, (Christian Lab) – Slide of the Week

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Earlier beta-amyloid (Aβ) plaque accumulation and a higher prevalence of Alzheimer’s Disease is seen in the Down syndrome (DS) population due to the triplication of chromosome 21 containing the amyloid precursor protein (APP) gene.