Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [11C]Pittsburgh Compound-B (PiB) positron emission tomography (PET) imaging, which has not been replicated with [18F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures.
[uw-reusable-content id=’29797′] At a Glance Loss of synapses, the connections between neurons that allow them to communicate, is a primary driver of cognitive decline in Alzheimer’s disease. Researchers expected a strong connection between synapse loss and tau buildup but the relationship was more nuanced than expected. Researchers found weak connections between tau buildup and synapse …
When Heather Huismann was in middle school she called the police on her teacher. “He was not teaching me very well,” Heather says.
Earlier beta-amyloid (Aβ) plaque accumulation and a higher prevalence of Alzheimer’s Disease is seen in the Down syndrome (DS) population due to the triplication of chromosome 21 containing the amyloid precursor protein (APP) gene.
Allison and Amber Westemeier get excited every time they take a trip to the Waisman Center from Oshkosh, WI.
The extent to which amyloid-β burden and neurofibrillary tau tangle burden are associated with synaptic degeneration in vivo is not well known.
The National Institutes of Health-funded Alzheimer’s Biomarkers Consortium – Down Syndrome (ABC-DS), a large multi-center research initiative to find biomarkers to track Alzheimer’s disease in Down syndrome. The Waisman Center is part of this multi-site study across the United States and at University of Cambridge in England. As part of the study, the Waisman Center …
The development of brain imaging techniques has helped us understand emotion, intellectual and developmental disabilities, and neurodegenerative diseases in ways we could not before.
Individuals with Down syndrome are at higher risk of developing Alzheimer’s disease, and it typically presents it at an earlier age than the general population. It is estimated that 90% of people with Down syndrome will have developed Alzheimer’s by age 65.
PET amyloid [11C]PiB imaging has revealed early detection of Aβ in the striatum in individuals with Down Syndrome (DS), a group carrying genetic risk for AD.
