New NIH-funded initiative will examine Alzheimer’s disease in people with Down syndrome

A team of researchers at the University of Wisconsin–Madison is part of a new multi-institution effort to better understand Alzheimer’s disease in adults with Down syndrome. Adults with Down syndrome are at high risk for …

Bradley T Christian, PhD – Slide of the Week

 Individuals with Down syndrome (DS) are at increased risk of developing Alzheimer’s disease (AD) and show the earliest signs of amyloid-β (Aβ) deposition in the striatum. The metric for tracking Aβ burden using PET radiotracers frequently uses average standard uptake value ratios (SUVr) in signature regions of the brain specific to Aβ deposition.

Bradley Christian, PhD – Slide of the Week

Trisomy 21 (Down syndrome; DS) leads to an overproduction of amyloid precursor protein and an increased risk for early Alzheimer’s disease. A study of the natural history of AD-related neuropathology is ongoing to gain an understanding of the distribution and time course of b-amyloid and tau burden in the brains of adults with DS.

Waisman Center partners on new multi-site NIH initiative to find Alzheimer’s biomarkers in Down syndrome

Brad Christian, PhD, Waisman investigator and associate professor of medical physics and psychiatry, is part of a new National Institutes of Health initiative to identify biomarkers and track the progression of Alzheimer’s in people with Down syndrome.