Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Waisman Investigator Daifeng Wang, PhD, associate professor of biostatistics and medical informatics, was featured on this article by the School of Medicine and Public Health on how artificial intelligence (AI) is advancing medical research at UW.
Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [11C]Pittsburgh Compound-B (PiB) positron emission tomography (PET) imaging, which has not been replicated with [18F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures.
[uw-reusable-content id=’29797′] At a Glance Loss of synapses, the connections between neurons that allow them to communicate, is a primary driver of cognitive decline in Alzheimer’s disease. Researchers expected a strong connection between synapse loss and tau buildup but the relationship was more nuanced than expected. Researchers found weak connections between tau buildup and synapse …
The gut microbiome is a potentially modifiable risk factor for Alzheimer’s disease (AD); however, understanding of its composition and function regarding AD pathology is limited.
Mean physical and behavioral depressive symptoms on the Reiss Screen of Maladaptive Behavior (RSMB) across four data collection cycles in sample of 262 adults with Down syndrome. Blue line is for those with low PET amyloid and green line for those with elevated PET amyloid.
Title: Congruent gene expression in Alexander disease model mice and human Alzheimer’s disease Legend: (A) A Rank-Rank Hypergeometric Overlap (RRHO) heatmap comparing a composite gene expression portrait of human Alzheimer’s disease (AD, X axis) with transcriptomic changes in hippocampus from Alexander disease model mice (GFAP mutation, Y axis) indicates high matching of up- and downregulated …
Genotypes are strongly associated with disease phenotypes, particularly in brain disorders. However, the molecular and cellular mechanisms behind this association remain elusive.
A team of University of Wisconsin–Madison scientists has developed the first 3D-printed brain tissue that can grow and function like typical brain tissue.
Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), Charcot-Marie-Tooth disease, and retinitis pigmentosa all have different manifestations and affect different body functions, but they are all connected by one mechanism: neurodegeneration.
Researchers a have identified a protein key to the development of a type of brain cell believed to play a role in disorders like Alzheimer’s and Parkinson’s diseases and used the discovery to grow the neurons from stem cells for the first time.
