Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Title: ERα Signaling Is Required for TrkB-Mediated Hippocampal Neuroprotection in Female Neonatal Mice after Hypoxic Ischemic Encephalopathy Legend: Increases in p-TrkB immuno and protein expressions are sexually differentiated and ERα dependent post-HI. A. Changes in MAP2 and p-TrkBY515 immunoexpression in the CL and IL hippocampi of ERα+/+ and ERα-/- P9 male and female mice were …
February 04, 2016 Adityarup “Rup” Chakravorty, Waisman Communications Each year, thousands of newborn babies suffer complications during pregnancy or birth that deprive their brains of oxygen and nutrient-rich blood and result in brain injury. This deprivation results in hypoxic ischemic encephalopathy (HIE), which can lead to long-term neurological issues such as learning disabilities, cerebral palsy …
Title: Up-regulation of NHE1 protein expression in reactive hippocampal astrocytes Legend: A.Expression of NHE1 protein in hippocampal astrocytes. Immunofluorescence signals of NHE1 and GFAP were shown under normoxia control or OGD (2 h) plus 0 h, 5 h, or 24 h REOX. Green: GFAP, red: NHE1 (arrows), blue: To-pro-3 nuclear staining. Scale Bar: 20 mm. …
