Using Discordant MZ Twins and Genome-wide Methylation Analyses to Identify Anxiety-relevant Genes – Three MZ (genetically identical) twin pairs were chosen to be clearly discordant for childhood cortisol levels and adolescent fMRI patterns in the amygdala that correlated with anxiety symptoms.
Month: January 2018
Anita Bhattacharyya, PhD – Slide of the Week
Generation of Human Induced Pluripotent Stem Cells from Unaffected Neonatal Skin Cells – We have generated and characterized iPSC clones from three unaffected, neonatal individuals using non-integrating episomal reprogramming plasmids expressing OCT4, SOX2, LIN28, KLF4, and c-Myc.
Waisman research into rare syndrome offers hope for families
Laurel Cooper is 8 years old and full of sass and spunk. She finds it hilarious when her older sister, Annalise, gets into trouble. She loves music, and being in the thick of things. Cooper also has Rett syndrome, a rare, non-inherited neurological disorder that mostly affects girls and causes severe deterioration in their ability to speak, eat, move and even breathe easily. Rett syndrome has no cure.
David Gamm, MD, PhD
Cell type-specific investigations commonly employ gene reporters or single-cell (sc) analytical techniques. However, reporter line development is arduous and generally limited to a single gene of interest, while scRNA-seq frequently yields equivocal results that preclude definitive cell identification.