The research in my lab focuses on identifying the mechanisms that stem cells use to create the asymmetric segregation of cargoes, to identify what other components are segregated, and to use this knowledge to improve stem cell aging.
Stem Cells
Anita Bhattacharyya, PhD – Slide of the Week
Generation of Human Induced Pluripotent Stem Cells from Unaffected Neonatal Skin Cells – We have generated and characterized iPSC clones from three unaffected, neonatal individuals using non-integrating episomal reprogramming plasmids expressing OCT4, SOX2, LIN28, KLF4, and c-Myc.
Randolph Ashton, PhD
Human pluripotent stem cell-derived neural organoids provide unprecedented potential to recapitulate human brain and spinal cord tissues in vitro. However, organoid morphogenesis relies upon cell-intrinsic self-assembly of biomimetic tissue structures in the absence of normal developmental constraints and morphogen signaling centers.
A decade after stem cell feat, research ramps up
A decade after scientists announced the development of induced pluripotent stem cells, Waisman investigators, including Su-Chun Zhang and David Gamm, continue to use these cells to research and develop potential therapies for several disorders and conditions, such as ALS, Parkinson’s disease, spinal cord injury, and macular degeneration.
“Assembling Tridimensional Brain Models to Study Human Development and Disease”
Sergiu P. Pasca, MD – Stanford University Pasca’s lab is interested in deciphering the molecular and cellular mechanisms of neuropsychiatric disorders. To achieve this, they employ a multidisciplinary approach involving human genetics, molecular and developmental …
Xinyu Zhao, PhD
Integrative Single-Cell Transcriptomics Reveal Molecular Networks Defining Neuronal Maturation during Postnatal Neurogenesis Legend: Left: An illustration of coronal section of Nissl-stained adult mouse brain; Confocal images showing that most of DsRed+ (red) cells in DCX-dsRed …
Am I a stem cell? How do I know?
Stem cells are remarkable cells that have the ability to become almost any kind of specialized cells in our bodies. Given this extraordinary potential, how does a stem cell keep from having an identity crisis? …
Brain cells by the billions
Leaders of the University of Wisconsin–Madison lab that first transformed human stem cells into brain cells have started a company that produces and sells specialized neurons to drug researchers. BrainXell develops neurons from stem cells …
Lighting up the search for a therapy for fragile X syndrome
Waisman Center researchers Anita Bhattacharyya and Xinyu Zhao are looking to make stem cells glow. That glow will tell them that they have successfully turned on a gene that is usually turned off in individuals …
Xinyu Zhao, PhD
Title: MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome Legend: Left: Models for FMRP regulation of the MDM2 and P53 pathway, which impacts adult neurogenesis and cognition. Right …