Waisman Center investigator David Gamm, MD, PhD, and affiliate Krishanu Saha, PhD, are part of a team of scientists at the University of Wisconsin- Madison who were recently granted a major award from the National …
Stem Cells
Twenty Years of Stem Cells
In 1998, UW–Madison developmental biologist James Thomson introduced the world to the first laboratory-derived human embryonic stem cells. Twenty years later, UW–Madison remains at the forefront of stem cell research. The Waisman Center at UW-Madison …
Masatoshi Suzuki, DVM, PhD – Slide of the Week
Human induced-pluripotent stem cells are a promising resource for propagation of myogenic progenitors. Our group recently reported a unique protocol for the derivation of myogenic progenitors directly (without genetic modification) from human pluripotent cells using free-floating spherical culture.
Seminar: Darcie Moore, PhD, “Mechanisms of Asymmetry in Neural Stem Cells”
The research in my lab focuses on identifying the mechanisms that stem cells use to create the asymmetric segregation of cargoes, to identify what other components are segregated, and to use this knowledge to improve stem cell aging.
Anita Bhattacharyya, PhD – Slide of the Week
Generation of Human Induced Pluripotent Stem Cells from Unaffected Neonatal Skin Cells – We have generated and characterized iPSC clones from three unaffected, neonatal individuals using non-integrating episomal reprogramming plasmids expressing OCT4, SOX2, LIN28, KLF4, and c-Myc.
Randolph Ashton, PhD
Human pluripotent stem cell-derived neural organoids provide unprecedented potential to recapitulate human brain and spinal cord tissues in vitro. However, organoid morphogenesis relies upon cell-intrinsic self-assembly of biomimetic tissue structures in the absence of normal developmental constraints and morphogen signaling centers.
A decade after stem cell feat, research ramps up
A decade after scientists announced the development of induced pluripotent stem cells, Waisman investigators, including Su-Chun Zhang and David Gamm, continue to use these cells to research and develop potential therapies for several disorders and conditions, such as ALS, Parkinson’s disease, spinal cord injury, and macular degeneration.
“Assembling Tridimensional Brain Models to Study Human Development and Disease”
Sergiu P. Pasca, MD – Stanford University Pasca’s lab is interested in deciphering the molecular and cellular mechanisms of neuropsychiatric disorders. To achieve this, they employ a multidisciplinary approach involving human genetics, molecular and developmental …
Xinyu Zhao, PhD
Integrative Single-Cell Transcriptomics Reveal Molecular Networks Defining Neuronal Maturation during Postnatal Neurogenesis Legend: Left: An illustration of coronal section of Nissl-stained adult mouse brain; Confocal images showing that most of DsRed+ (red) cells in DCX-dsRed …
Am I a stem cell? How do I know?
Stem cells are remarkable cells that have the ability to become almost any kind of specialized cells in our bodies. Given this extraordinary potential, how does a stem cell keep from having an identity crisis? …