Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
At a Glance A newly discovered protein marker on the surface of a retinal cell could help pave the way for cell therapies that restore vision in people with currently incurable forms of blindness. Research in the lab of Waisman investigator David Gamm, MD, PhD, professor of ophthalmology and visual sciences at the University of …
Call us to learn more and find out if your baby is eligible to join!608-228-4940 We invite your child to take part in a research study about how children’s visual function is related to their future development. In other words, we are trying to identify the link between the eyes and the brain. We invite …
Photoreceptors (PRs) are the primary visual sensory cells, and their loss leads to blindness that is currently incurable. Although cell replacement therapy holds promise, success is hindered by our limited understanding of PR axon growth during development and regeneration.
Waisman Center investigator David Gamm, MD, PhD, and Waisman affiliate Kris Saha, PhD, have published a proof-of-concept method to correct Best disease – an inherited form of macular degeneration that causes blindness, and that is currently untreatable. To read the article, click here.
Loss of vision can frequently lead to a loss of independence and a reduction in quality of life for an individual. The Tekin lab is interested in harnessing new mobile technologies to provide access to environmental information for persons with vision loss.
Numerous protocols have been described that produce neural retina from human pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids. While nearly all such methods yield at least partial segments of highly mature-appearing retinal structure, variabilities exist within and between organoids that can change over a protracted time course of differentiation.
To mark the 20th anniversary of the stem cell discovery at UW-Madison, the Wisconsin State Journal featured a series of stories on stem cell research, highlighting the work of Waisman Center investigators David Gamm, Anita Bhattacharyya, Su-Chun Zhang, affiliate Randall Ashton, as well as Waisman Biomanufacturing. Researchers at the Waisman Center use stem cells— undifferentiated …
Waisman Center investigator David Gamm, MD, PhD, and affiliate Krishanu Saha, PhD, are part of a team of scientists at the University of Wisconsin- Madison who were recently granted a major award from the National Institute of Health’s Somatic Cell Genome Editing Consortium (SCGE). This award will support research focused on developing quality control methods …
Children who cannot effectively read print because of a visual, physical, perceptual, developmental, cognitive or learning disability, are considered to have a print disability.
Cell type-specific investigations commonly employ gene reporters or single-cell (sc) analytical techniques. However, reporter line development is arduous and generally limited to a single gene of interest, while scRNA-seq frequently yields equivocal results that preclude definitive cell identification.
