Cell type-specific investigations commonly employ gene reporters or single-cell (sc) analytical techniques. However, reporter line development is arduous and generally limited to a single gene of interest, while scRNA-seq frequently yields equivocal results that preclude definitive cell identification.
David Gamm
A decade after stem cell feat, research ramps up
A decade after scientists announced the development of induced pluripotent stem cells, Waisman investigators, including Su-Chun Zhang and David Gamm, continue to use these cells to research and develop potential therapies for several disorders and conditions, such as ALS, Parkinson’s disease, spinal cord injury, and macular degeneration.
David Gamm, MD, PhD
Title: Interconversion of early VSX2WT and VSX2R200Q hiPSC-OV phenotypes by pharmacological manipulation of WNT signaling. Legend: Pharmacological manipulation of the WNT signaling pathway during in vitro retinogenesis in hiPSCs affects the cell fate decision between …
David Gamm, MD, PhD
Title: Pharmacological modulation of photoreceptor outer segment degradation in Best disease patient-derived hiPSC-RPE Legend: (a) Representative western blot analysis comparing the amount of the POS protein RHO in untreated and VPA-treated (500 µmol/l) BD hiPSC-RPE at …
UW Eye Researchers Publish Second Study of Stem Cells and Blinding Eye Disease
A team of eye researchers at the University of Wisconsin-Madison have used a custom stem cell model of a rare but blinding eye disease to test whether a commonly used drug might offer hope for treatment.
Vision Research Month
June is Vision Research Awareness Month and the Waisman Center is home to a comprehensive vision research program led by David Gamm, MD, PhD. Gamm, a Waisman Center investigator, associate professor of ophthalmology and visual sciences, and Director of the McPherson Eye Research Institute, studies human retinal development and potential therapies for retinal degenerative diseases.
Waisman Center art featured at campus exhibit
Katie Sweeney, Waisman Center Communications The McPherson Eye Research Institute unveiled its new exhibit, Seeing Beyond Disabilities: Unique Insights, on January 29 in the Mandelbaum and Albert Vision Gallery at the Wisconsin Institutes for Medical Research. The exhibit features …
Gamm’s research aims to treat blinding diseases
Inherited and acquired degenerative diseases of the retina are a significant cause of incurable vision loss worldwide. David Gamm, MD, PhD, utilizes stem cell technology to test ways to preserve or restore vision in people …
Family supports UW-Madison research on eye disease
When Madison attorney David Walsh learned 17 years ago that his sons have a genetic disorder that causes blindness, he went into action mode.
Stem Cell Advance
A recent issue of The Why Files features stem advances at the University of Wisconsin-Madison, including several scientists at the Waisman Center.