David Gamm, MD, PhD – Slide of the Week

Numerous protocols have been described that produce neural retina from human pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids. While nearly all such methods yield at least partial segments of highly mature-appearing retinal structure, variabilities exist within and between organoids that can change over a protracted time course of differentiation.

David Gamm, MD, PhD

Cell type-specific investigations commonly employ gene reporters or single-cell (sc) analytical techniques. However, reporter line development is arduous and generally limited to a single gene of interest, while scRNA-seq frequently yields equivocal results that preclude definitive cell identification.

A decade after stem cell feat, research ramps up

A decade after scientists announced the development of induced pluripotent stem cells, Waisman investigators, including Su-Chun Zhang and David Gamm, continue to use these cells to research and develop potential therapies for several disorders and conditions, such as ALS, Parkinson’s disease, spinal cord injury, and macular degeneration.

Vision Research Month

June is Vision Research Awareness Month and the Waisman Center is home to a comprehensive vision research program led by David Gamm, MD, PhD. Gamm, a Waisman Center investigator, associate professor of ophthalmology and visual sciences, and Director of the McPherson Eye Research Institute, studies human retinal development and potential therapies for retinal degenerative diseases.