Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Brain injuries caused by a lack of oxygen and blood flow affect many thousands of children every year, yet “we still don’t have effective treatments for them,” says Waisman researcher Peter Ferrazzano, MD.
February 04, 2016 Adityarup “Rup” Chakravorty, Waisman Communications Each year, thousands of newborn babies suffer complications during pregnancy or birth that deprive their brains of oxygen and nutrient-rich blood and result in brain injury. This deprivation results in hypoxic ischemic encephalopathy (HIE), which can lead to long-term neurological issues such as learning disabilities, cerebral palsy …
Title: Suppression of microglia activation after hypoxia-ischemia results in age-dependent improvements in neurologic injury. Legend: P9 and P30 mice were exposed to unilateral hypoxia-ischemia and treated with minocycline or vehicle. A, B. Double immunohistological staining for Iba1 (green) and MAP2 (red) proteins in the CA1 region of the hippocampus at 2 days post-HI is shown. …
Title: Up-regulation of NHE1 protein expression in reactive hippocampal astrocytes Legend: A.Expression of NHE1 protein in hippocampal astrocytes. Immunofluorescence signals of NHE1 and GFAP were shown under normoxia control or OGD (2 h) plus 0 h, 5 h, or 24 h REOX. Green: GFAP, red: NHE1 (arrows), blue: To-pro-3 nuclear staining. Scale Bar: 20 mm. …
