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Hypoxia-ischemia
Pelin Cengiz, MD – Slide of the Week
TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury
Estrogen receptor alpha mediates protection against hypoxic ischemic brain injury in newborn female mice, study shows
In her practice as a pediatric intensivist, Cengiz noticed that even with similar brain injuries, functional outcomes varied from child to child. “So, I began wondering what could be the potential mechanisms of these differences in outcome”, Cengiz says.
Peter Ferrazzano, MD – Slide of the Week
Neuroinflammation plays an important role in ischemic brain injury and recovery, however the interplay between brain development and the neuroinflammatory response is poorly understood. We previously described age-dependent differences in the microglial response and the effect of microglial inhibition.