A new computational pipeline connects disease and discovery at the cellular level
Could Alzheimer’s disease and schizophrenia be biologically connected? A new computational model, scGRNom (single-cell Gene Regulatory Network prediction from multi- omics), developed by researchers at the University of Wisconsin-Madison, harnesses the power of multi-omics and …
July 1, 2021
The identities of enzymes: study further defines the function of a potential target for Alzheimer’s therapy
A new study from the lab of UW-Madison professor of medicine Luigi Puglielli, MD, PhD, opens a door to potential treatments for diseases of age, such as Alzheimer’s disease, by defining the roles of two enzymes that are imperative to protein production. “Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism” was published in April in the journal Communications Biology.
April 20, 2021
Individualized brain cell grafts reverse Parkinson’s symptoms in monkeys
Grafting neurons grown from monkeys’ own cells into their brains relieved the debilitating movement and depression symptoms associated with Parkinson’s disease, researchers at the University of Wisconsin–Madison reported today.
March 1, 2021
New NIH-funded initiative will examine Alzheimer’s disease in people with Down syndrome
A team of researchers at the University of Wisconsin–Madison is part of a new multi-institution effort to better understand Alzheimer’s disease in adults with Down syndrome. Adults with Down syndrome are at high risk for …
October 26, 2020Stem cells can repair Parkinson’s-damaged circuits in mouse brains
The mature brain is infamously bad at repairing itself following damage like that caused by trauma or strokes, or from degenerative diseases like Parkinson’s. Stem cells, which are endlessly adaptable, have offered the promise of better neural repair. But the brain’s precisely tuned complexity has stymied the development of clinical treatments.
September 29, 2020New initiative to study Parkinson disease
Su-Chun Zhang, MD, PhD, the Steenbock Professor in Behavioral and Neural Sciences at the University of Wisconsin-Madison and Waisman Center investigator, is part of an interdisciplinary team of researchers selected by the Aligning Science Across Parkinson’s (ASAP) initiative to receive $9 million over three years for the “Parkinson5D: Deconstructing Proximal Disease Mechanisms Across Cells, Space and Progression” or PD5D project.
September 21, 2020Running toward renewal: new study links physical activity with cognitive health
Research has shown voluntary running is an activity most commonly associated with the reversal of negative impacts of aging and neurodegeneration, but little is understood about why that is.
August 4, 2020- More Neurodegenerative posts
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